Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310177884> ?p ?o ?g. }
- W4310177884 abstract "Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here we examine the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) in type 1 diabetes using high-resolution single-cell multiomics and flow cytometry on longitudinally-collected peripheral blood samples. Our results confirm that iLD-IL-2 selectively expands thymic-derived FOXP3+HELIOS+ regulatory T cells and CD56bright NK cells, and show that the treatment reduces the frequency of IL-21-producing CD4+ T cells and of two innate-like mucosal-associated invariant T and Vγ9Vδ2 CD8+ T cell subsets. The cellular changes induced by iLD-IL-2 associate with an anti-inflammatory gene expression signature, which remains detectable in all T and NK cell subsets analysed one month after treatment. These findings warrant investigations into the potential longer-term clinical benefits of iLD-IL-2 in immunotherapy." @default.
- W4310177884 created "2022-11-30" @default.
- W4310177884 creator A5006457698 @default.
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- W4310177884 creator A5067546262 @default.
- W4310177884 creator A5069678448 @default.
- W4310177884 creator A5080039974 @default.
- W4310177884 date "2022-11-28" @default.
- W4310177884 modified "2023-09-30" @default.
- W4310177884 title "Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes" @default.
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