Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310191325> ?p ?o ?g. }
- W4310191325 abstract "Abstract Axonal injury and demyelination occur in demyelinating diseases, such as multiple sclerosis, and the detachment of myelin from axons precedes its degradation. Paranodes are the areas at which each layer of the myelin sheath adheres tightly to axons. The destruction of nodal and paranodal structures during inflammation is an important pathophysiology of various neurological disorders. However, the underlying pathological changes in these structures remain unclear. Kallikrein 6 (Klk6), a serine protease produced by oligodendrocytes, is involved in demyelinating diseases. In the present study, we intraperitoneally injected mice with LPS for several days and examined changes in the localization of Klk6. Transient changes in the intracellular localization of Klk6 to paranodes in the spinal cord were observed during LPS-induced systemic inflammation. However, these changes were not detected in the upper part of brain white matter. LPS-induced changes were suppressed by minocycline, suggesting the involvement of microglia. Moreover, nodal lengths were elongated in LPS-treated wild-type mice, but not in LPS-treated Klk6-KO mice. These results demonstrate the potential involvement of Klk6 in the process of demyelination." @default.
- W4310191325 created "2022-11-30" @default.
- W4310191325 creator A5008140945 @default.
- W4310191325 creator A5052182246 @default.
- W4310191325 creator A5069616885 @default.
- W4310191325 date "2022-11-28" @default.
- W4310191325 modified "2023-10-18" @default.
- W4310191325 title "Systemic inflammation leads to changes in the intracellular localization of Klk6 in oligodendrocytes in spinal cord white matter" @default.
- W4310191325 cites W1496161405 @default.
- W4310191325 cites W1969102065 @default.
- W4310191325 cites W1974665574 @default.
- W4310191325 cites W1974960001 @default.
- W4310191325 cites W1976152366 @default.
- W4310191325 cites W1976429374 @default.
- W4310191325 cites W1983206476 @default.
- W4310191325 cites W1986436947 @default.
- W4310191325 cites W1986611577 @default.
- W4310191325 cites W1993023126 @default.
- W4310191325 cites W2002232189 @default.
- W4310191325 cites W2015278187 @default.
- W4310191325 cites W2019985266 @default.
- W4310191325 cites W2037443393 @default.
- W4310191325 cites W2047899819 @default.
- W4310191325 cites W2048085214 @default.
- W4310191325 cites W2053313069 @default.
- W4310191325 cites W2060575579 @default.
- W4310191325 cites W2077076478 @default.
- W4310191325 cites W2084020188 @default.
- W4310191325 cites W2084574028 @default.
- W4310191325 cites W2085470511 @default.
- W4310191325 cites W2085558085 @default.
- W4310191325 cites W2092927038 @default.
- W4310191325 cites W2111686584 @default.
- W4310191325 cites W2118966296 @default.
- W4310191325 cites W2120143347 @default.
- W4310191325 cites W2123355863 @default.
- W4310191325 cites W2138651252 @default.
- W4310191325 cites W2140179680 @default.
- W4310191325 cites W2144096099 @default.
- W4310191325 cites W2147556339 @default.
- W4310191325 cites W2150616072 @default.
- W4310191325 cites W2150626397 @default.
- W4310191325 cites W2161687477 @default.
- W4310191325 cites W2300512617 @default.
- W4310191325 cites W2337852945 @default.
- W4310191325 cites W2581532382 @default.
- W4310191325 cites W2590972582 @default.
- W4310191325 cites W2749385941 @default.
- W4310191325 cites W2767141291 @default.
- W4310191325 cites W2803677733 @default.
- W4310191325 cites W2898901335 @default.
- W4310191325 cites W2899141782 @default.
- W4310191325 cites W2935539797 @default.
- W4310191325 cites W2950805359 @default.
- W4310191325 cites W2964483356 @default.
- W4310191325 cites W2971944560 @default.
- W4310191325 cites W3085718835 @default.
- W4310191325 cites W3092360164 @default.
- W4310191325 cites W3098192264 @default.
- W4310191325 cites W3208100349 @default.
- W4310191325 cites W4225295787 @default.
- W4310191325 doi "https://doi.org/10.21203/rs.3.rs-2295377/v1" @default.
- W4310191325 hasPublicationYear "2022" @default.
- W4310191325 type Work @default.
- W4310191325 citedByCount "0" @default.
- W4310191325 crossrefType "posted-content" @default.
- W4310191325 hasAuthorship W4310191325A5008140945 @default.
- W4310191325 hasAuthorship W4310191325A5052182246 @default.
- W4310191325 hasAuthorship W4310191325A5069616885 @default.
- W4310191325 hasBestOaLocation W43101913251 @default.
- W4310191325 hasConcept C126838900 @default.
- W4310191325 hasConcept C142724271 @default.
- W4310191325 hasConcept C143409427 @default.
- W4310191325 hasConcept C169760540 @default.
- W4310191325 hasConcept C203014093 @default.
- W4310191325 hasConcept C2776914184 @default.
- W4310191325 hasConcept C2776985911 @default.
- W4310191325 hasConcept C2778609137 @default.
- W4310191325 hasConcept C2779830541 @default.
- W4310191325 hasConcept C2780640218 @default.
- W4310191325 hasConcept C2780775167 @default.
- W4310191325 hasConcept C2781192897 @default.
- W4310191325 hasConcept C529278444 @default.
- W4310191325 hasConcept C71924100 @default.
- W4310191325 hasConcept C79879829 @default.
- W4310191325 hasConcept C86803240 @default.
- W4310191325 hasConcept C95444343 @default.
- W4310191325 hasConceptScore W4310191325C126838900 @default.
- W4310191325 hasConceptScore W4310191325C142724271 @default.
- W4310191325 hasConceptScore W4310191325C143409427 @default.
- W4310191325 hasConceptScore W4310191325C169760540 @default.
- W4310191325 hasConceptScore W4310191325C203014093 @default.
- W4310191325 hasConceptScore W4310191325C2776914184 @default.
- W4310191325 hasConceptScore W4310191325C2776985911 @default.
- W4310191325 hasConceptScore W4310191325C2778609137 @default.
- W4310191325 hasConceptScore W4310191325C2779830541 @default.
- W4310191325 hasConceptScore W4310191325C2780640218 @default.
- W4310191325 hasConceptScore W4310191325C2780775167 @default.
- W4310191325 hasConceptScore W4310191325C2781192897 @default.
- W4310191325 hasConceptScore W4310191325C529278444 @default.