Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310208529> ?p ?o ?g. }
- W4310208529 endingPage "1535" @default.
- W4310208529 startingPage "1526" @default.
- W4310208529 abstract "Myelodysplasic syndromes (MDS) are diseases occurring mainly in the elderly population. Although hematopoietic stem cell transplantation is the only hope for cure, a majority of the patients suffering from MDS are too old or frail for intensive treatment regimens such as intensive chemotherapy and transplantation. The gold standard for those patients is currently treatment with hypomethylating agents, although real-life data could not reproduce the overall survival rates reported for the pivotal azacitidine phase III study. MDS treatment is often inspired by treatment for acute myeloid leukemia (AML). The new gold standard for elderly and frail patients not able to undergo intensive treatment regimens in AML is the combination of hypomethylating agents with venetoclax, a BCL-2 inhibitor that also showed excellent treatment outcomes in other hematological malignancies. In this review, we explain the rationale for the use of venetoclax in hematological malignancies, study outcomes available so far and the current knowledge of its use in MDS." @default.
- W4310208529 created "2022-11-30" @default.
- W4310208529 creator A5001140118 @default.
- W4310208529 creator A5044033798 @default.
- W4310208529 creator A5046612855 @default.
- W4310208529 creator A5047951694 @default.
- W4310208529 date "2022-12-08" @default.
- W4310208529 modified "2023-10-16" @default.
- W4310208529 title "Role of Bcl‐2 inhibition in myelodysplastic syndromes" @default.
- W4310208529 cites W100647374 @default.
- W4310208529 cites W146673805 @default.
- W4310208529 cites W1598054001 @default.
- W4310208529 cites W1711791220 @default.
- W4310208529 cites W187238933 @default.
- W4310208529 cites W1973421470 @default.
- W4310208529 cites W1986382133 @default.
- W4310208529 cites W1996887331 @default.
- W4310208529 cites W2003948069 @default.
- W4310208529 cites W2009183786 @default.
- W4310208529 cites W2013781993 @default.
- W4310208529 cites W2020151485 @default.
- W4310208529 cites W2021333892 @default.
- W4310208529 cites W2026625631 @default.
- W4310208529 cites W2036274324 @default.
- W4310208529 cites W2036788408 @default.
- W4310208529 cites W2041356430 @default.
- W4310208529 cites W2061297480 @default.
- W4310208529 cites W2063374921 @default.
- W4310208529 cites W2066053804 @default.
- W4310208529 cites W2078294866 @default.
- W4310208529 cites W2081279521 @default.
- W4310208529 cites W2082454745 @default.
- W4310208529 cites W2087821794 @default.
- W4310208529 cites W2088406835 @default.
- W4310208529 cites W2090076603 @default.
- W4310208529 cites W2098454439 @default.
- W4310208529 cites W2106082819 @default.
- W4310208529 cites W2107781341 @default.
- W4310208529 cites W2113271378 @default.
- W4310208529 cites W2118322536 @default.
- W4310208529 cites W2118771330 @default.
- W4310208529 cites W2122761773 @default.
- W4310208529 cites W2131256397 @default.
- W4310208529 cites W2139347878 @default.
- W4310208529 cites W2149982846 @default.
- W4310208529 cites W2156794452 @default.
- W4310208529 cites W2160347999 @default.
- W4310208529 cites W2165056381 @default.
- W4310208529 cites W2192121806 @default.
- W4310208529 cites W2278956317 @default.
- W4310208529 cites W2326726820 @default.
- W4310208529 cites W2339658711 @default.
- W4310208529 cites W2369297677 @default.
- W4310208529 cites W2463012969 @default.
- W4310208529 cites W2513849557 @default.
- W4310208529 cites W2517675534 @default.
- W4310208529 cites W2549790759 @default.
- W4310208529 cites W2560286007 @default.
- W4310208529 cites W2740367874 @default.
- W4310208529 cites W2748033095 @default.
- W4310208529 cites W2770858121 @default.
- W4310208529 cites W2784405738 @default.
- W4310208529 cites W2792666902 @default.
- W4310208529 cites W2794499016 @default.
- W4310208529 cites W2795301499 @default.
- W4310208529 cites W2806970239 @default.
- W4310208529 cites W2884234015 @default.
- W4310208529 cites W2884238005 @default.
- W4310208529 cites W2898284215 @default.
- W4310208529 cites W2907201550 @default.
- W4310208529 cites W2922237910 @default.
- W4310208529 cites W2946882253 @default.
- W4310208529 cites W2948436219 @default.
- W4310208529 cites W2953259441 @default.
- W4310208529 cites W2980824860 @default.
- W4310208529 cites W2998901800 @default.
- W4310208529 cites W3013447738 @default.
- W4310208529 cites W3015984203 @default.
- W4310208529 cites W3027107600 @default.
- W4310208529 cites W3048827006 @default.
- W4310208529 cites W3096867320 @default.
- W4310208529 cites W3098856610 @default.
- W4310208529 cites W3105196097 @default.
- W4310208529 cites W3118429009 @default.
- W4310208529 cites W3130267604 @default.
- W4310208529 cites W3164043037 @default.
- W4310208529 cites W3183147912 @default.
- W4310208529 cites W3212443859 @default.
- W4310208529 cites W3212602214 @default.
- W4310208529 cites W3214477141 @default.
- W4310208529 cites W4225332958 @default.
- W4310208529 cites W4225546878 @default.
- W4310208529 cites W4283271244 @default.
- W4310208529 doi "https://doi.org/10.1002/ijc.34377" @default.
- W4310208529 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36444492" @default.
- W4310208529 hasPublicationYear "2022" @default.
- W4310208529 type Work @default.
- W4310208529 citedByCount "0" @default.