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- W4310222663 endingPage "1190" @default.
- W4310222663 startingPage "1167" @default.
- W4310222663 abstract "Pneumocystis jirovecii is an opportunistic, human-specific fungus that causes Pneumocystis pneumonia (PCP). PCP symptoms are nonspecific. A patient with P. jirovecii and another lung infection faces a diagnostic challenge. It may be difficult to determine which of these agents is responsible for the clinical symptoms, preventing effective treatment. Diagnostic and treatment efforts have been made more difficult by the rising frequency with which coronavirus 2019 (COVID-19) and PCP co-occur.Herein, we provide a comprehensive review of clinical and pharmacological recommendations along with a literature review of PCP in immunocompromised patients focusing on HIV-uninfected patients.PCP may be masked by identifying co-existing pathogens that are not necessarily responsible for the observed infection. Patients with severe form COVID-19 should be examined for underlying immunodeficiency, and co-infections must be considered as co-infection with P. jirovecii may worsen COVID-19's severity and fatality. PCP should be investigated in patients with PCP risk factors who come with pneumonia and suggestive radiographic symptoms but have not previously received PCP prophylaxis. PCP prophylaxis should be explored in individuals with various conditions that impair the immune system, depending on their PCP risk." @default.
- W4310222663 created "2022-11-30" @default.
- W4310222663 creator A5003361347 @default.
- W4310222663 creator A5016059013 @default.
- W4310222663 creator A5019126037 @default.
- W4310222663 creator A5025740294 @default.
- W4310222663 creator A5030199783 @default.
- W4310222663 creator A5037657429 @default.
- W4310222663 date "2022-11-02" @default.
- W4310222663 modified "2023-09-27" @default.
- W4310222663 title "A comprehensive clinical guide for <i>Pneumocystis jirovecii</i> pneumonia: a missing therapeutic target in HIV-uninfected patients" @default.
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