FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310231985> ?p ?o ?g. }

• W4310231985 endingPage "e14432" @default.
• W4310231985 startingPage "e14432" @default.
• W4310231985 abstract "Recent studies have identified ribonucleotide reductase subunit M2 (RRM2) as a putative promoter of tumors. However, no systematic analysis of its carcinogenicity has been conducted.The potential functions of RRM2 in various tumor types were investigated using data from the Genotype-Tissue Expression (GTEx), the Clinical Proteomic Tumor Analysis Consortium (CPTAC), the Cancer Genome Atlas (TCGA), the Human Protein Atlas (HPA), cBioPortal, GEPIA, String, and Gene Set Enrichment Analysis (GSEA). We analyzed the difference in mRNA and protein expression, pathological stage, survival, mutation, tumor microenvironment (TME), and immune cell infiltration in relation to RRM2. Meanwhile, using TCGA and the Tumor Immune Estimation Resource 2 (TIMER 2), the associations between RRM2 expression, immune infiltration, and immune-related genes were assessed. Additionally, CCK-8, Edu and RT-PCR assays were used to validate that RRM2 acts as an oncogene in liver cancer cells and its association with HBx. A cohort of liver hepatocellular carcinoma (LIHC) patients (n=154) from Huashan Hospital was analyzed for the expression of RRM2 and the association between RRM2 and immune infiltration.Using the GTEx and TCGA databases, we discovered that 28 tumors expressed RRM2 at significantly higher levels than the corresponding normal tissues. Increased RRM2 expression may be predictive of a poor overall survival (OS) in patients with seven different cancers. GO, KEGG, and GSEA analyses revealed that the biological process of RRM2 was associated with the regulation of carcinogenic processes and immune pathways in a variety of tumor types. The expression of RRM2 was highly correlated with maker genes involved in immune activation and immunosuppression, immune checkpoints, DNA mismatch repair system (MMR), and the infiltration levels of Tregs and macrophages (TAMs), suggesting that the carcinogenic effect of RRM2 may be achieved by regulating immune related genes. Moreover, as demonstrated by CCK-8 and Edu assays, RRM2 was an oncogene in liver cancer cells. We confirmed for the first time that RRM2 was significantly upregulated by HBx, suggesting that RRM2 may be a key regulator of LIHC induced by HBV. IHC analysis validated the upregulated expression of RRM2 protein and its correlation with immune infiltration makers in a LIHC patient cohort.RRM2 may be a valuable molecular biomarker for predicting prognosis and immunotherapeutic efficacy in pan-cancer, particularly in LIHC." @default.
• W4310231985 created "2022-11-30" @default.
• W4310231985 creator A5016647301 @default.
• W4310231985 creator A5033732336 @default.
• W4310231985 creator A5036779226 @default.
• W4310231985 creator A5058508021 @default.
• W4310231985 creator A5058654086 @default.
• W4310231985 creator A5063897088 @default.
• W4310231985 creator A5067613871 @default.
• W4310231985 creator A5072606309 @default.
• W4310231985 date "2022-11-28" @default.
• W4310231985 modified "2023-10-12" @default.
• W4310231985 title "A pan-cancer analysis of the oncogenic role of ribonucleotide reductase subunit M2 in human tumors" @default.
• W4310231985 cites W1955438485 @default.
• W4310231985 cites W1986150533 @default.
• W4310231985 cites W2008771266 @default.
• W4310231985 cites W2012034410 @default.
• W4310231985 cites W2035618305 @default.
• W4310231985 cites W2056207883 @default.
• W4310231985 cites W2073300038 @default.
• W4310231985 cites W2114843025 @default.
• W4310231985 cites W2130410032 @default.
• W4310231985 cites W2149441684 @default.
• W4310231985 cites W2262375396 @default.
• W4310231985 cites W2297581901 @default.
• W4310231985 cites W2473218705 @default.
• W4310231985 cites W2554092504 @default.
• W4310231985 cites W2587048937 @default.
• W4310231985 cites W2607129810 @default.
• W4310231985 cites W2607211817 @default.
• W4310231985 cites W2626742338 @default.
• W4310231985 cites W2725398806 @default.
• W4310231985 cites W2755994178 @default.
• W4310231985 cites W2885845278 @default.
• W4310231985 cites W2900569176 @default.
• W4310231985 cites W2907549567 @default.
• W4310231985 cites W2914396734 @default.
• W4310231985 cites W2917187119 @default.
• W4310231985 cites W2921460161 @default.
• W4310231985 cites W2946657092 @default.
• W4310231985 cites W2970534831 @default.
• W4310231985 cites W2992781394 @default.
• W4310231985 cites W2995684511 @default.
• W4310231985 cites W3012809083 @default.
• W4310231985 cites W3016490190 @default.
• W4310231985 cites W3027286012 @default.
• W4310231985 cites W3028304854 @default.
• W4310231985 cites W3029836467 @default.
• W4310231985 cites W3034982015 @default.
• W4310231985 cites W3039455661 @default.
• W4310231985 cites W3041259235 @default.
• W4310231985 cites W3084157821 @default.
• W4310231985 cites W3084161163 @default.
• W4310231985 cites W3094377523 @default.
• W4310231985 cites W3099369776 @default.
• W4310231985 cites W3107285902 @default.
• W4310231985 cites W3114685627 @default.
• W4310231985 cites W3115864540 @default.
• W4310231985 cites W3129029057 @default.
• W4310231985 cites W3134129620 @default.
• W4310231985 cites W3157258448 @default.
• W4310231985 cites W3159523017 @default.
• W4310231985 cites W3160911287 @default.
• W4310231985 cites W3164666605 @default.
• W4310231985 cites W3193631208 @default.
• W4310231985 cites W3201715468 @default.
• W4310231985 cites W3209090874 @default.
• W4310231985 cites W3209815348 @default.
• W4310231985 cites W4200527284 @default.
• W4310231985 cites W4220790939 @default.
• W4310231985 cites W4223462256 @default.
• W4310231985 cites W4226019578 @default.
• W4310231985 doi "https://doi.org/10.7717/peerj.14432" @default.
• W4310231985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36518297" @default.
• W4310231985 hasPublicationYear "2022" @default.
• W4310231985 type Work @default.
• W4310231985 citedByCount "3" @default.
• W4310231985 countsByYear W43102319852023 @default.
• W4310231985 crossrefType "journal-article" @default.
• W4310231985 hasAuthorship W4310231985A5016647301 @default.
• W4310231985 hasAuthorship W4310231985A5033732336 @default.
• W4310231985 hasAuthorship W4310231985A5036779226 @default.
• W4310231985 hasAuthorship W4310231985A5058508021 @default.
• W4310231985 hasAuthorship W4310231985A5058654086 @default.
• W4310231985 hasAuthorship W4310231985A5063897088 @default.
• W4310231985 hasAuthorship W4310231985A5067613871 @default.
• W4310231985 hasAuthorship W4310231985A5072606309 @default.
• W4310231985 hasBestOaLocation W43102319851 @default.
• W4310231985 hasConcept C104292427 @default.
• W4310231985 hasConcept C104317684 @default.
• W4310231985 hasConcept C158163496 @default.
• W4310231985 hasConcept C2776107976 @default.
• W4310231985 hasConcept C4710235 @default.
• W4310231985 hasConcept C502942594 @default.
• W4310231985 hasConcept C54355233 @default.
• W4310231985 hasConcept C555283112 @default.
• W4310231985 hasConcept C6856738 @default.
• W4310231985 hasConcept C86803240 @default.

• next