FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310232008> ?p ?o ?g. }

• W4310232008 endingPage "e750" @default.
• W4310232008 startingPage "e750" @default.
• W4310232008 abstract "Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health problem demanding further research in the context of host-pathogen interactions and vaccine development. Furthermore, the cross-continental spread of monkeypox has reaffirmed the need for devoting attention to human poxviruses in general, as they represent potential bioterrorism agents. Currently, smallpox vaccines are utilized in immunization efforts against monkeypox, an unsurprising fact considering their genomic and phenotypic similarities. Though it offers long-lasting protection against smallpox, its protective effects against human monkeypox continue to be explored, with encouraging results. Taking this into account, this works aims at utilizing in silico tools to identify potent peptide-based epitopes stemming from the variola virus and monkeypox virus proteomes, to devise a vaccine that would offer significant protection against smallpox and monkeypox. In theory, a vaccine that offers cross-protection against variola and monkeypox would also protect against related viruses, at least in severe clinical manifestation. Herein, we introduce a novel multi-epitope mRNA vaccine design that exploits these two viral proteomes to elicit long-lasting humoral and cellular immunity. Special consideration was taken in ensuring that the vaccine candidate elicits a Th1 immune response, correlated with protection against clinically severe disease for both viruses. Immune system simulations and physicochemical and safety analyses characterize our vaccine candidate as antigenically potent, safe, and overall stable. The protein product displays high binding affinity towards relevant immune receptors. Furthermore, the vaccine candidate is to elicit a protective, humoral and Th1-dominated cellular immune response that lasts over five years. Lastly, we build a case about the rapidity and convenience of circumventing the live attenuated vaccine platform using mRNA vaccine technology." @default.
• W4310232008 created "2022-11-30" @default.
• W4310232008 creator A5042792221 @default.
• W4310232008 creator A5085887677 @default.
• W4310232008 date "2022-11-28" @default.
• W4310232008 modified "2023-10-18" @default.
• W4310232008 title "Multi-epitope mRNA Vaccine Design that Exploits Variola Virus and Monkeypox Virus Proteins for Elicitation of Long-lasting Humoral and Cellular Protection Against Severe Disease" @default.
• W4310232008 cites W1056381329 @default.
• W4310232008 cites W1481608537 @default.
• W4310232008 cites W1503364994 @default.
• W4310232008 cites W1768303176 @default.
• W4310232008 cites W1803102843 @default.
• W4310232008 cites W1838517089 @default.
• W4310232008 cites W1916576747 @default.
• W4310232008 cites W1939433055 @default.
• W4310232008 cites W1940767994 @default.
• W4310232008 cites W1965615590 @default.
• W4310232008 cites W1967790863 @default.
• W4310232008 cites W1973980688 @default.
• W4310232008 cites W1977189837 @default.
• W4310232008 cites W1988620094 @default.
• W4310232008 cites W1989174828 @default.
• W4310232008 cites W1994509201 @default.
• W4310232008 cites W1995691015 @default.
• W4310232008 cites W2004740669 @default.
• W4310232008 cites W2007243761 @default.
• W4310232008 cites W2007866706 @default.
• W4310232008 cites W2012625502 @default.
• W4310232008 cites W2020828649 @default.
• W4310232008 cites W2022232407 @default.
• W4310232008 cites W2037418603 @default.
• W4310232008 cites W2040928488 @default.
• W4310232008 cites W2048142263 @default.
• W4310232008 cites W2065514542 @default.
• W4310232008 cites W2074107830 @default.
• W4310232008 cites W2080876451 @default.
• W4310232008 cites W2086561953 @default.
• W4310232008 cites W2092965819 @default.
• W4310232008 cites W2098729022 @default.
• W4310232008 cites W2102367710 @default.
• W4310232008 cites W2116535514 @default.
• W4310232008 cites W2120467372 @default.
• W4310232008 cites W2122779464 @default.
• W4310232008 cites W2125616632 @default.
• W4310232008 cites W2127635589 @default.
• W4310232008 cites W2136580520 @default.
• W4310232008 cites W2138056290 @default.
• W4310232008 cites W2147416962 @default.
• W4310232008 cites W2156872221 @default.
• W4310232008 cites W2157597421 @default.
• W4310232008 cites W2171268876 @default.
• W4310232008 cites W2171295581 @default.
• W4310232008 cites W2171596973 @default.
• W4310232008 cites W2176718959 @default.
• W4310232008 cites W2564003941 @default.
• W4310232008 cites W2588895177 @default.
• W4310232008 cites W2611314002 @default.
• W4310232008 cites W2736143002 @default.
• W4310232008 cites W2782708334 @default.
• W4310232008 cites W2885159220 @default.
• W4310232008 cites W3015575322 @default.
• W4310232008 cites W3037309373 @default.
• W4310232008 cites W3048380411 @default.
• W4310232008 cites W3113090860 @default.
• W4310232008 cites W3184092482 @default.
• W4310232008 cites W3194535095 @default.
• W4310232008 cites W3212975416 @default.
• W4310232008 cites W4206950245 @default.
• W4310232008 cites W4211177539 @default.
• W4310232008 cites W4226068113 @default.
• W4310232008 cites W4244736178 @default.
• W4310232008 cites W4281893676 @default.
• W4310232008 cites W4282913866 @default.
• W4310232008 cites W4294637087 @default.
• W4310232008 doi "https://doi.org/10.20883/medical.e750" @default.
• W4310232008 hasPublicationYear "2022" @default.
• W4310232008 type Work @default.
• W4310232008 citedByCount "0" @default.
• W4310232008 crossrefType "journal-article" @default.
• W4310232008 hasAuthorship W4310232008A5042792221 @default.
• W4310232008 hasAuthorship W4310232008A5085887677 @default.
• W4310232008 hasBestOaLocation W43102320081 @default.
• W4310232008 hasConcept C104317684 @default.
• W4310232008 hasConcept C151730666 @default.
• W4310232008 hasConcept C159047783 @default.
• W4310232008 hasConcept C159654299 @default.
• W4310232008 hasConcept C195616568 @default.
• W4310232008 hasConcept C203014093 @default.
• W4310232008 hasConcept C22070199 @default.
• W4310232008 hasConcept C2522874641 @default.
• W4310232008 hasConcept C2778011067 @default.
• W4310232008 hasConcept C2778417375 @default.
• W4310232008 hasConcept C2778545548 @default.
• W4310232008 hasConcept C2779272165 @default.
• W4310232008 hasConcept C2779343474 @default.
• W4310232008 hasConcept C2781356689 @default.
• W4310232008 hasConcept C2908589346 @default.
• W4310232008 hasConcept C2909788366 @default.

• next