Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310235712> ?p ?o ?g. }
- W4310235712 abstract "Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population. Inflammation in HSK is chemokine-dependent, particularly CXCL10 and less so the CC chemokines. The atypical chemokine receptor-2 (ACKR2) is a decoy receptor predominantly for pro-inflammatory CC chemokines, which regulates the inflammatory response by scavenging inflammatory chemokines thereby modulating leukocyte infiltration. Deletion of ACKR2 exacerbates and delays the resolution of the inflammatory response in most models. ACKR2 also regulates lymphangiogenesis and mammary duct development through the recruitment of tissue-remodeling macrophages. Here, we demonstrate a dose-dependent upregulation of ACKR2 during corneal HSV-1 infection. At an HSV inoculum dose of 5.4 x 10 5 pfu, but not at higher dose, ACKR2 deficient mice showed prolonged clinical signs of HSK, increased infiltration of leukocytes and persistent corneal neovascularization. Viral clearance and T cell activation were similar in ACKR2 -/- and wild type mice, despite a transient diminished expression of CD40 and CD86 in dendritic cells. The data suggest that ACKR2 fine-tunes the inflammatory response and the level of neovascularization in the HSK." @default.
- W4310235712 created "2022-11-30" @default.
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- W4310235712 date "2022-11-28" @default.
- W4310235712 modified "2023-10-14" @default.
- W4310235712 title "The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis" @default.
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- W4310235712 doi "https://doi.org/10.3389/fimmu.2022.1054260" @default.
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