FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310238872> ?p ?o ?g. }

• W4310238872 abstract "Abstract Creation of sub-epithelial voids within scarred vocal folds via ultrafast laser ablation may help in localization of injectable therapeutic biomaterials towards an improved treatment for vocal fold scarring. Several ultrafast laser surgery probes have been developed for precise ablation of surface tissues; however, these probes lack the tight beam focusing required for sub-surface ablation in highly scattering tissues such as vocal folds. Here, we present a miniaturized ultrafast laser surgery probe designed to perform sub-epithelial ablation in vocal folds. The requirement of high numerical aperture for sub-surface ablation, in addition to the small form factor and side-firing architecture required for clinical use, made for a challenging optical design. An Inhibited Coupling guiding Kagome hollow core photonic crystal fiber delivered micro-Joule level ultrashort pulses from a high repetition rate fiber laser towards a custom-built miniaturized objective, producing a 1/e 2 focal beam radius of 1.12 ± 0.10 μm and covering a 46 × 46 μm 2 scan area. The probe could deliver up to 3.8 μJ pulses to the tissue surface at 40% transmission efficiency through the entire system, providing significantly higher fluences at the focal plane than were required for sub-epithelial ablation. To assess surgical performance, we performed ablation studies on freshly excised porcine hemi-larynges and found that large area sub-epithelial voids could be created within vocal folds by mechanically translating the probe tip across the tissue surface using external stages. Finally, injection of a model biomaterial into a 1 × 2 mm 2 void created 114 ± 30 μm beneath the vocal fold epithelium surface indicated improved localization when compared to direct injection into the tissue without a void, suggesting that our probe may be useful for pre-clinical evaluation of injectable therapeutic biomaterials for vocal fold scarring therapy. With future developments, the surgical system presented here may enable treatment of vocal fold scarring in a clinical setting." @default.
• W4310238872 created "2022-11-30" @default.
• W4310238872 creator A5002754861 @default.
• W4310238872 creator A5032561028 @default.
• W4310238872 creator A5046415197 @default.
• W4310238872 creator A5054565048 @default.
• W4310238872 creator A5062789726 @default.
• W4310238872 creator A5068828027 @default.
• W4310238872 creator A5069326511 @default.
• W4310238872 creator A5085192893 @default.
• W4310238872 creator A5090133918 @default.
• W4310238872 date "2022-11-29" @default.
• W4310238872 modified "2023-09-26" @default.
• W4310238872 title "Ultrafast laser surgery probe for sub-surface ablation to enable biomaterial injection in vocal folds" @default.
• W4310238872 cites W1933862284 @default.
• W4310238872 cites W1966905725 @default.
• W4310238872 cites W1978002293 @default.
• W4310238872 cites W1992225609 @default.
• W4310238872 cites W1992761016 @default.
• W4310238872 cites W2002853968 @default.
• W4310238872 cites W2003565503 @default.
• W4310238872 cites W2007557254 @default.
• W4310238872 cites W2016438499 @default.
• W4310238872 cites W2020295760 @default.
• W4310238872 cites W2030370165 @default.
• W4310238872 cites W2031845997 @default.
• W4310238872 cites W2043393623 @default.
• W4310238872 cites W2046486819 @default.
• W4310238872 cites W2050040458 @default.
• W4310238872 cites W2058786215 @default.
• W4310238872 cites W2072428487 @default.
• W4310238872 cites W2073907593 @default.
• W4310238872 cites W2075001108 @default.
• W4310238872 cites W2075165926 @default.
• W4310238872 cites W2077015098 @default.
• W4310238872 cites W2077644606 @default.
• W4310238872 cites W2099148432 @default.
• W4310238872 cites W2108226844 @default.
• W4310238872 cites W2118337650 @default.
• W4310238872 cites W2143405185 @default.
• W4310238872 cites W2144088295 @default.
• W4310238872 cites W2150750581 @default.
• W4310238872 cites W2293022251 @default.
• W4310238872 cites W2415037482 @default.
• W4310238872 cites W2460980143 @default.
• W4310238872 cites W2535373271 @default.
• W4310238872 cites W2557899104 @default.
• W4310238872 cites W2801469225 @default.
• W4310238872 cites W2913737454 @default.
• W4310238872 cites W2914099587 @default.
• W4310238872 cites W2970408967 @default.
• W4310238872 cites W3010908592 @default.
• W4310238872 cites W3082291453 @default.
• W4310238872 cites W3103373921 @default.
• W4310238872 cites W3180757054 @default.
• W4310238872 cites W3185413703 @default.
• W4310238872 cites W4293233799 @default.
• W4310238872 cites W613239630 @default.
• W4310238872 cites W96720577 @default.
• W4310238872 doi "https://doi.org/10.1038/s41598-022-24446-5" @default.
• W4310238872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36446830" @default.
• W4310238872 hasPublicationYear "2022" @default.
• W4310238872 type Work @default.
• W4310238872 citedByCount "4" @default.
• W4310238872 countsByYear W43102388722023 @default.
• W4310238872 crossrefType "journal-article" @default.
• W4310238872 hasAuthorship W4310238872A5002754861 @default.
• W4310238872 hasAuthorship W4310238872A5032561028 @default.
• W4310238872 hasAuthorship W4310238872A5046415197 @default.
• W4310238872 hasAuthorship W4310238872A5054565048 @default.
• W4310238872 hasAuthorship W4310238872A5062789726 @default.
• W4310238872 hasAuthorship W4310238872A5068828027 @default.
• W4310238872 hasAuthorship W4310238872A5069326511 @default.
• W4310238872 hasAuthorship W4310238872A5085192893 @default.
• W4310238872 hasAuthorship W4310238872A5090133918 @default.
• W4310238872 hasBestOaLocation W43102388721 @default.
• W4310238872 hasConcept C120665830 @default.
• W4310238872 hasConcept C121332964 @default.
• W4310238872 hasConcept C126322002 @default.
• W4310238872 hasConcept C136229726 @default.
• W4310238872 hasConcept C141071460 @default.
• W4310238872 hasConcept C171250308 @default.
• W4310238872 hasConcept C178596936 @default.
• W4310238872 hasConcept C192562407 @default.
• W4310238872 hasConcept C2776829320 @default.
• W4310238872 hasConcept C2778305132 @default.
• W4310238872 hasConcept C2778414984 @default.
• W4310238872 hasConcept C2778902805 @default.
• W4310238872 hasConcept C2779188808 @default.
• W4310238872 hasConcept C2780336059 @default.
• W4310238872 hasConcept C2780474809 @default.
• W4310238872 hasConcept C2780477314 @default.
• W4310238872 hasConcept C520434653 @default.
• W4310238872 hasConcept C71924100 @default.
• W4310238872 hasConceptScore W4310238872C120665830 @default.
• W4310238872 hasConceptScore W4310238872C121332964 @default.
• W4310238872 hasConceptScore W4310238872C126322002 @default.
• W4310238872 hasConceptScore W4310238872C136229726 @default.
• W4310238872 hasConceptScore W4310238872C141071460 @default.
• W4310238872 hasConceptScore W4310238872C171250308 @default.

• next