Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310238904> ?p ?o ?g. }
- W4310238904 abstract "Abstract Thousands of genes are perturbed by cancer, and these disturbances can be seen in transcriptome, methylation, somatic mutation, and copy number variation omics studies. Understanding their connectivity patterns as an omnigenic neighbourhood in a molecular interaction network (interactome) is a key step towards advancing knowledge of the molecular mechanisms underlying cancers. Here, we introduce a unified connectivity line ( CLine ) to pinpoint omics-specific omnigenic patterns across 15 curated cancers. Taking advantage of the universality of CLine , we distinguish the peripheral and core genes for each omics aspect. We propose a network-based framework, multi-omics periphery and core (MOPC), to combine peripheral and core genes from different omics into a button-like structure. On the basis of network proximity, we provide evidence that core genes tend to be specifically perturbed in one omics, but the peripheral genes are diversely perturbed in multiple omics. And the core of one omics is regulated by multiple omics peripheries. Finally, we take the MOPC as an omnigenic neighbourhood, describe its characteristics, and explore its relative contribution to network-based mechanisms of cancer. We were able to present how multi-omics perturbations percolate through the human interactome and contribute to an integrated periphery and core." @default.
- W4310238904 created "2022-11-30" @default.
- W4310238904 creator A5006181213 @default.
- W4310238904 creator A5054607668 @default.
- W4310238904 creator A5060109811 @default.
- W4310238904 creator A5065203912 @default.
- W4310238904 date "2022-11-29" @default.
- W4310238904 modified "2023-10-18" @default.
- W4310238904 title "Multi-omics peripheral and core regions of cancer" @default.
- W4310238904 cites W1557420513 @default.
- W4310238904 cites W1964716329 @default.
- W4310238904 cites W1977878983 @default.
- W4310238904 cites W1987531565 @default.
- W4310238904 cites W1992062845 @default.
- W4310238904 cites W2023568503 @default.
- W4310238904 cites W2038222027 @default.
- W4310238904 cites W2038920443 @default.
- W4310238904 cites W2040848353 @default.
- W4310238904 cites W2041073071 @default.
- W4310238904 cites W2047031939 @default.
- W4310238904 cites W2056782561 @default.
- W4310238904 cites W2060833569 @default.
- W4310238904 cites W2062533676 @default.
- W4310238904 cites W2070082005 @default.
- W4310238904 cites W2077132193 @default.
- W4310238904 cites W2088891952 @default.
- W4310238904 cites W2095319945 @default.
- W4310238904 cites W2098597355 @default.
- W4310238904 cites W2102140136 @default.
- W4310238904 cites W2110553827 @default.
- W4310238904 cites W2110684048 @default.
- W4310238904 cites W2113105800 @default.
- W4310238904 cites W2114031931 @default.
- W4310238904 cites W2121443461 @default.
- W4310238904 cites W2137200212 @default.
- W4310238904 cites W2146060062 @default.
- W4310238904 cites W2154866190 @default.
- W4310238904 cites W2155496693 @default.
- W4310238904 cites W2158217645 @default.
- W4310238904 cites W2195783463 @default.
- W4310238904 cites W2329659234 @default.
- W4310238904 cites W2469213152 @default.
- W4310238904 cites W2487261336 @default.
- W4310238904 cites W2559028527 @default.
- W4310238904 cites W2560866543 @default.
- W4310238904 cites W2607269937 @default.
- W4310238904 cites W2612436700 @default.
- W4310238904 cites W2616561032 @default.
- W4310238904 cites W2626606138 @default.
- W4310238904 cites W2734365998 @default.
- W4310238904 cites W2735155748 @default.
- W4310238904 cites W2760366406 @default.
- W4310238904 cites W2777635693 @default.
- W4310238904 cites W2785792383 @default.
- W4310238904 cites W2795941120 @default.
- W4310238904 cites W2796153225 @default.
- W4310238904 cites W2796408191 @default.
- W4310238904 cites W2808223587 @default.
- W4310238904 cites W2808363286 @default.
- W4310238904 cites W2891691532 @default.
- W4310238904 cites W2894795605 @default.
- W4310238904 cites W2897334647 @default.
- W4310238904 cites W2922229918 @default.
- W4310238904 cites W2944565226 @default.
- W4310238904 cites W2947617922 @default.
- W4310238904 cites W2952835495 @default.
- W4310238904 cites W2965299749 @default.
- W4310238904 cites W2966010373 @default.
- W4310238904 cites W2974103075 @default.
- W4310238904 cites W2979761477 @default.
- W4310238904 cites W2980232174 @default.
- W4310238904 cites W2982703253 @default.
- W4310238904 cites W3006500278 @default.
- W4310238904 cites W3028304854 @default.
- W4310238904 cites W3037705365 @default.
- W4310238904 cites W3042542048 @default.
- W4310238904 cites W3081528139 @default.
- W4310238904 cites W3091027434 @default.
- W4310238904 cites W3115259909 @default.
- W4310238904 cites W3122647175 @default.
- W4310238904 cites W3129339917 @default.
- W4310238904 cites W3135375269 @default.
- W4310238904 cites W3159961265 @default.
- W4310238904 cites W3199622685 @default.
- W4310238904 cites W3201444946 @default.
- W4310238904 cites W3202201721 @default.
- W4310238904 cites W3203747717 @default.
- W4310238904 cites W3204152948 @default.
- W4310238904 cites W3215994910 @default.
- W4310238904 cites W4234623159 @default.
- W4310238904 cites W4240710608 @default.
- W4310238904 cites W4253785452 @default.
- W4310238904 doi "https://doi.org/10.1038/s41540-022-00258-1" @default.
- W4310238904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36446819" @default.
- W4310238904 hasPublicationYear "2022" @default.
- W4310238904 type Work @default.
- W4310238904 citedByCount "0" @default.
- W4310238904 crossrefType "journal-article" @default.
- W4310238904 hasAuthorship W4310238904A5006181213 @default.
- W4310238904 hasAuthorship W4310238904A5054607668 @default.