FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310239154> ?p ?o ?g. }

• W4310239154 abstract "Background Patients with hypertrophic cardiomyopathy (HCM) are at risk of ventricular arrhythmia (VA) attributed to abnormal electrical activation arising from myocardial fibrosis and myocyte disarray. We sought to quantify intra‐QRS peaks (QRSp) in high‐resolution ECGs as a measure of abnormal activation to predict late VA in patients with HCM. Methods and Results Prospectively enrolled patients with HCM (n=143, age 53±14 years) with prophylactic implantable cardioverter‐defibrillators had 3‐minute, high‐resolution (1024 Hz), digital 12‐lead ECGs recorded during intrinsic rhythm. For each precordial lead, QRSp was defined as the total number of peaks detected in the QRS complex that deviated from a smoothing filtered version of the QRS. The VA end point was appropriate implantable cardioverter‐defibrillator therapy during 5‐year prospective follow‐up. After 5 years, 21 (16%) patients had VA. Patients who were VA positive had greater QRSp (6.0 [4.0–7.0] versus 4.0 [2.0–5.0]; P <0.01) and lower left ventricular ejection fraction (57±11 versus 62±9; P =0.038) compared with patients who were VA negative, but had similar established HCM risk metrics. Receiver operating characteristic analysis revealed that QRSp discriminated VA (area under the curve=0.76; P <0.001), with a QRSp ≥4 achieving 91% sensitivity and 39% specificity. The annual VA rate was greater in patients with QRSp ≥4 versus QRSp <4 (4.4% versus 0.98%; P =0.012). In multivariable Cox regression, age <50 years (hazard ratio [HR], 2.53; P =0.009) and QRSp (HR per QRS peak, 1.41; P =0.009) predicted VA after adjusting for established HCM risk metrics. In patients aged <50 years, the annual VA rate was 0.0% for QRSp <4 compared with 6.9% for QRSp ≥4 ( P =0.012). Conclusions QRSp predicted VA in patients with HCM who were eligible for an implantable cardioverter‐defibrillator after adjusting for established HCM risk metrics, such that each additional QRS peak increases VA risk by 40%. QRSp <4 was associated with a <1% annual VA risk in all patients, and no VA risk among those aged <50 years. This novel ECG metric may improve patient selection for prophylactic implantable cardioverter‐defibrillator therapy by identifying those with low VA risk. These findings require further validation in a lower risk HCM cohort. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT02560844." @default.
• W4310239154 created "2022-11-30" @default.
• W4310239154 creator A5002978899 @default.
• W4310239154 creator A5003758535 @default.
• W4310239154 creator A5019195810 @default.
• W4310239154 creator A5028591599 @default.
• W4310239154 creator A5030428751 @default.
• W4310239154 creator A5042688574 @default.
• W4310239154 creator A5047179300 @default.
• W4310239154 creator A5067460303 @default.
• W4310239154 creator A5076999391 @default.
• W4310239154 creator A5077573193 @default.
• W4310239154 creator A5080468171 @default.
• W4310239154 creator A5090651414 @default.
• W4310239154 creator A5090951642 @default.
• W4310239154 date "2022-12-06" @default.
• W4310239154 modified "2023-10-01" @default.
• W4310239154 title "Automated Quantification of Abnormal QRS Peaks From High‐Resolution ECGs Predicts Late Ventricular Arrhythmias in Hypertrophic Cardiomyopathy: A 5‐Year Prospective Multicenter Study" @default.
• W4310239154 cites W109657961 @default.
• W4310239154 cites W1501558997 @default.
• W4310239154 cites W1632920654 @default.
• W4310239154 cites W1976695248 @default.
• W4310239154 cites W1986232649 @default.
• W4310239154 cites W1991727042 @default.
• W4310239154 cites W1993605117 @default.
• W4310239154 cites W2049057276 @default.
• W4310239154 cites W2063814494 @default.
• W4310239154 cites W2069024767 @default.
• W4310239154 cites W2070320179 @default.
• W4310239154 cites W2080695376 @default.
• W4310239154 cites W2085283933 @default.
• W4310239154 cites W2089081033 @default.
• W4310239154 cites W2095212928 @default.
• W4310239154 cites W2099871067 @default.
• W4310239154 cites W2107103201 @default.
• W4310239154 cites W2109116553 @default.
• W4310239154 cites W2119361626 @default.
• W4310239154 cites W2134949933 @default.
• W4310239154 cites W2142446243 @default.
• W4310239154 cites W2158640186 @default.
• W4310239154 cites W2334784459 @default.
• W4310239154 cites W2547726837 @default.
• W4310239154 cites W2736178470 @default.
• W4310239154 cites W2769399136 @default.
• W4310239154 cites W2906780479 @default.
• W4310239154 cites W2940793653 @default.
• W4310239154 cites W2945166483 @default.
• W4310239154 cites W3036703356 @default.
• W4310239154 cites W3104775553 @default.
• W4310239154 cites W3106752039 @default.
• W4310239154 cites W3113392623 @default.
• W4310239154 cites W3122281778 @default.
• W4310239154 doi "https://doi.org/10.1161/jaha.122.026025" @default.
• W4310239154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36444865" @default.
• W4310239154 hasPublicationYear "2022" @default.
• W4310239154 type Work @default.
• W4310239154 citedByCount "4" @default.
• W4310239154 countsByYear W43102391542022 @default.
• W4310239154 countsByYear W43102391542023 @default.
• W4310239154 crossrefType "journal-article" @default.
• W4310239154 hasAuthorship W4310239154A5002978899 @default.
• W4310239154 hasAuthorship W4310239154A5003758535 @default.
• W4310239154 hasAuthorship W4310239154A5019195810 @default.
• W4310239154 hasAuthorship W4310239154A5028591599 @default.
• W4310239154 hasAuthorship W4310239154A5030428751 @default.
• W4310239154 hasAuthorship W4310239154A5042688574 @default.
• W4310239154 hasAuthorship W4310239154A5047179300 @default.
• W4310239154 hasAuthorship W4310239154A5067460303 @default.
• W4310239154 hasAuthorship W4310239154A5076999391 @default.
• W4310239154 hasAuthorship W4310239154A5077573193 @default.
• W4310239154 hasAuthorship W4310239154A5080468171 @default.
• W4310239154 hasAuthorship W4310239154A5090651414 @default.
• W4310239154 hasAuthorship W4310239154A5090951642 @default.
• W4310239154 hasBestOaLocation W43102391542 @default.
• W4310239154 hasConcept C111773187 @default.
• W4310239154 hasConcept C126322002 @default.
• W4310239154 hasConcept C164705383 @default.
• W4310239154 hasConcept C188816634 @default.
• W4310239154 hasConcept C207103383 @default.
• W4310239154 hasConcept C2775935837 @default.
• W4310239154 hasConcept C2777093960 @default.
• W4310239154 hasConcept C2778198053 @default.
• W4310239154 hasConcept C2778797674 @default.
• W4310239154 hasConcept C2780185194 @default.
• W4310239154 hasConcept C44249647 @default.
• W4310239154 hasConcept C50382708 @default.
• W4310239154 hasConcept C58471807 @default.
• W4310239154 hasConcept C71924100 @default.
• W4310239154 hasConcept C78085059 @default.
• W4310239154 hasConceptScore W4310239154C111773187 @default.
• W4310239154 hasConceptScore W4310239154C126322002 @default.
• W4310239154 hasConceptScore W4310239154C164705383 @default.
• W4310239154 hasConceptScore W4310239154C188816634 @default.
• W4310239154 hasConceptScore W4310239154C207103383 @default.
• W4310239154 hasConceptScore W4310239154C2775935837 @default.
• W4310239154 hasConceptScore W4310239154C2777093960 @default.
• W4310239154 hasConceptScore W4310239154C2778198053 @default.
• W4310239154 hasConceptScore W4310239154C2778797674 @default.
• W4310239154 hasConceptScore W4310239154C2780185194 @default.
• W4310239154 hasConceptScore W4310239154C44249647 @default.

• next