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- W4310244166 abstract "Metabolic syndrome is a set of risk factors that consist of abdominal obesity, arterial hypertension, alterations in the lipid profile, and hyperglycemia. The current therapeutic strategy includes polypharmacy, using three or more drugs to control each syndrome component. However, this approach has drawbacks that could lead to therapeutic failure. Multitarget drugs are molecules with the ability to act on different targets simultaneously and are an attractive alternative for treating complex diseases such as metabolic syndrome. Previously, we identified a triamide derivative of 5-aminoanthranilic acid that exhibited hypoglycemic, hypolipemic, and antihypertensive activities simultaneously. In the present study, we report the synthesis and in combo evaluation of new derivatives of anthranilic acid, intending to identify the primary structural factors that improve the activity over metabolic syndrome-related parameters. We found that substitution on position 5, incorporation of 3,4-dimethoxyphenyl substituents, and having a free carboxylic acid group lead to the in vitro inhibition of HMG-CoA reductase, and simultaneously the diminution of the serum levels of glucose, triglycerides, and cholesterol in a diet-induced in vivo model." @default.
- W4310244166 created "2022-11-30" @default.
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- W4310244166 date "2022-11-25" @default.
- W4310244166 modified "2023-10-18" @default.
- W4310244166 title "In Combo Studies for the Optimization of 5-Aminoanthranilic Acid Derivatives as Potential Multitarget Drugs for the Management of Metabolic Syndrome" @default.
- W4310244166 cites W134153864 @default.
- W4310244166 cites W1505664810 @default.
- W4310244166 cites W1534819381 @default.
- W4310244166 cites W1806569691 @default.
- W4310244166 cites W1808513053 @default.
- W4310244166 cites W1940806157 @default.
- W4310244166 cites W1967553740 @default.
- W4310244166 cites W1967999753 @default.
- W4310244166 cites W1969838378 @default.
- W4310244166 cites W1972966873 @default.
- W4310244166 cites W1975792122 @default.
- W4310244166 cites W1980023462 @default.
- W4310244166 cites W1986153018 @default.
- W4310244166 cites W1986306961 @default.
- W4310244166 cites W1989971569 @default.
- W4310244166 cites W2009867031 @default.
- W4310244166 cites W2011464582 @default.
- W4310244166 cites W2011534124 @default.
- W4310244166 cites W2015310731 @default.
- W4310244166 cites W2031008553 @default.
- W4310244166 cites W2048816044 @default.
- W4310244166 cites W2055943486 @default.
- W4310244166 cites W2057574300 @default.
- W4310244166 cites W2060294481 @default.
- W4310244166 cites W2060556615 @default.
- W4310244166 cites W2072664608 @default.
- W4310244166 cites W2095479639 @default.
- W4310244166 cites W2099768941 @default.
- W4310244166 cites W2109057881 @default.
- W4310244166 cites W2120862552 @default.
- W4310244166 cites W2144125211 @default.
- W4310244166 cites W2145892592 @default.
- W4310244166 cites W2161456956 @default.
- W4310244166 cites W2167563726 @default.
- W4310244166 cites W2220358814 @default.
- W4310244166 cites W2272500893 @default.
- W4310244166 cites W2277657693 @default.
- W4310244166 cites W2317110841 @default.
- W4310244166 cites W2318527110 @default.
- W4310244166 cites W2397410154 @default.
- W4310244166 cites W2407316691 @default.
- W4310244166 cites W2586236648 @default.
- W4310244166 cites W2601262926 @default.
- W4310244166 cites W2750477650 @default.
- W4310244166 cites W2752320193 @default.
- W4310244166 cites W2763920048 @default.
- W4310244166 cites W2766278684 @default.
- W4310244166 cites W2769250691 @default.
- W4310244166 cites W2783084500 @default.
- W4310244166 cites W2783897572 @default.
- W4310244166 cites W2790715244 @default.
- W4310244166 cites W2791151548 @default.
- W4310244166 cites W2792023288 @default.
- W4310244166 cites W2793435470 @default.
- W4310244166 cites W2803712102 @default.
- W4310244166 cites W2805906447 @default.
- W4310244166 cites W2895781484 @default.
- W4310244166 cites W2896688061 @default.
- W4310244166 cites W2901115689 @default.
- W4310244166 cites W2907471688 @default.
- W4310244166 cites W2912627248 @default.
- W4310244166 cites W2939900094 @default.
- W4310244166 cites W2964860433 @default.
- W4310244166 cites W3000114476 @default.
- W4310244166 cites W3002287592 @default.
- W4310244166 cites W3010707930 @default.
- W4310244166 cites W3011401480 @default.
- W4310244166 cites W3016296419 @default.
- W4310244166 cites W3017351696 @default.
- W4310244166 cites W3038530635 @default.
- W4310244166 cites W3043986491 @default.
- W4310244166 cites W3081896791 @default.
- W4310244166 cites W3082935544 @default.
- W4310244166 cites W3102417563 @default.
- W4310244166 cites W3109089421 @default.
- W4310244166 cites W3124708443 @default.
- W4310244166 cites W3126638370 @default.
- W4310244166 cites W3126662165 @default.
- W4310244166 cites W3185426739 @default.