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- W4310249229 endingPage "140631" @default.
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- W4310249229 abstract "The production of polymer bioconjugates at high monomer dilutions and on a large scale suffers a severe limitation as there are typically tedious procedures for prior deoxygenation, catalyst removal and intermittent product purification. In this contribution, the development of suspended-catalysts-based membrane reactors (SCBMR) aims to combine the benefits of heterogeneous catalysis and industrialized membrane technology to streamline the upscaling syntheses of value-added bioactive materials through a robust photopolymerization strategy. The poly(ethylene glycol) methyl ether (MPEG)-linked polyphthalocyanine (PPc-MPEG) nanoplatelets were synthesized using a solid-phase synthetic strategy, followed by exfoliation and post-functionalization with MPEG. Under the catalysis of PPc-MPEG nanoplatelets, well-defined polymers were obtained within a few hours under near-infrared (NIR) light irradiation with excellent control over the molecular weight and polydispersity in batch. The versatility of SCBMR was highlighted through significant simplicity with respect to the elimination of time-consuming prior deoxygenation, catalyst removal and intermittent purification procedures. In addition, SCBMR was expanded as means for designing complex protein-polymer bioconjugates from multiple proteins (e.g., bovine serum albumin, human serum albumin, horseradish peroxidase) and monomer classes. In comparison to dialysis process, SCBMR could afford the bioconjugates with purity exceeding 99% in 4.2 diavolumes. As such, the combination of polyphthalocyanine nanoplatelets and industrialized membrane technology provides a general and highly accessible methodology for the synthetic scaling of bioactive materials with optimized structures for various biomedical applications." @default.
- W4310249229 created "2022-11-30" @default.
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- W4310249229 date "2023-01-01" @default.
- W4310249229 modified "2023-10-12" @default.
- W4310249229 title "Developing membrane reactors with suspended polyphthalocyanine nanoplatelets for upscaling syntheses of protein-polymer bioconjugates" @default.
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- W4310249229 doi "https://doi.org/10.1016/j.cej.2022.140631" @default.
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