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• W4310249304 endingPage "140619" @default.
• W4310249304 startingPage "140619" @default.
• W4310249304 abstract "Immunotherapy has played an important role in the treatment of malignant tumors. Efforts in this area are focused on exploiting a facile scaffold-based cancer vaccine with admirable efficacy and favorable property for tumor immunotherapy. Herein, an implantable sponge-nanofiber Janus scaffold with lyophilization-inactivated cancer cells, immune adjuvant imiquimod, and 5-fluorouracil (5-FU) spatially loading has been developed for tumor postoperative immuno-chemotherapy. The inactivated cancer cells and imiquimod encapsulated macroporous sponge of the scaffold can act as an immune niche to initiate a potent immune response. While the 5-FU loaded nanofibers can not only enhance the mechanical property of the scaffold, but also increase the anti-tumor immunity of the scaffold by directly killing cancer cells and depleting myeloid-derived suppressor cells to remodel the tumor immunosuppression microenvironment. Based on these features, the excellent anti-recurrence and anti-metastasis efficiency of the composited Janus scaffold have been demonstrated in the mouse breast tumor model. Thus, it is convinced that the proposed Janus scaffold spatially encapsulated with lyophilization-inactivated cancer cell vaccines and chemotherapeutic agents will provide novel sights for combination therapy after tumor surgery." @default.
• W4310249304 created "2022-11-30" @default.
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• W4310249304 date "2023-01-01" @default.
• W4310249304 modified "2023-10-15" @default.
• W4310249304 title "Lyophilization-inactivated cancer cells composited Janus scaffold for tumor postoperative immuno-chemotherapy" @default.
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• W4310249304 doi "https://doi.org/10.1016/j.cej.2022.140619" @default.
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