FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310251159> ?p ?o ?g. }

• W4310251159 endingPage "124" @default.
• W4310251159 startingPage "116" @default.
• W4310251159 abstract "Introduction. In modern practice, suppositories are prepared by hand rolling method or fusion. 3D printing can overcome the disadvantages of traditional suppository manufacturing methods and solve the problems of personalization. 3D printing makes it possible to manufacture drug-loaded suppositories without the use of molds or other physical support. The current studies have a number of limitations, and the printing of one suppository requires a long time. This report proposes a method of 3D modeling and 3D printing to produce personalized suppositories by fusion. Aim. Various sizes and shapes suppositories silicone molds development by molding method from hydrophilic, lipophilic and amphiphilic bases. Materials and methods. Suppository bases: cocoa butter (Luker, Colombia), polyethylene glycol (PEG) 1500 (Merck KGaA, Germany), PEG-400 (Merck KGaA, Germany), Witepsol H-15 (Chimmed Group, Russia); pharmaceutical substance: paracetamol (Hebei Jiheng (Group) Pharmaceutical Co. Ltd, China); filaments for 3D printing: polyethylene terephthalate (PET-G natural, LLC PrintProdakt, Russia); silicone two-component platinum, hardness Shore 30A (China); solvents: Acetonitrile Grade HPLC (Merck KGaA, Germany). The design of the both casting and master molds of suppositories was carried out using the KOMPAS-3D version 17.1. Master molds were printed by Picaso PRO 250 and Picaso X Pro 3D printers. Mold segments were obtained by filling master molds with a mixture of two-component silicone. Suppositories were obtained by molding method. Their average weight and standard deviation were determined. Paracetamol concentration in suppositories was carried out by UV spectrophotometry on a UV-1240 mini spectrophotometer (Shimadzu, Япония). Silicone molds were soaked and washed in hot water with surfactants. Washouts from the molds were taken by soaking the mold. Results and discussion. The torpedo-shaped form was chosen as the model form of suppositories. For the chosen form, three volumes of suppositories were designed: 3.32 ml; 1.5 ml and 0.25 ml. Silicone molds were designed and manufactured for all volumes. The cast suppositories were examined for compliance with the regulatory documentation for the dosage form, the average weight and mass uniformity were evaluated. Suppositories with paracetamol were made. A procedure for cleaning the obtained silicone molds has been developed. Conclusion. The resulting silicone molds make it possible to obtain suppositories in accordance with the regulatory documentation for the suppositories. Silicone molds have significant advantages compared to analogues of metal or polymeric molds." @default.
• W4310251159 created "2022-11-30" @default.
• W4310251159 creator A5015210539 @default.
• W4310251159 creator A5055785185 @default.
• W4310251159 creator A5071816463 @default.
• W4310251159 creator A5075163362 @default.
• W4310251159 creator A5080296843 @default.
• W4310251159 creator A5090941746 @default.
• W4310251159 date "2022-11-27" @default.
• W4310251159 modified "2023-09-26" @default.
• W4310251159 title "Development of Suppositories Silicone Molds Using Additive Technologies" @default.
• W4310251159 cites W2035513563 @default.
• W4310251159 cites W2523910993 @default.
• W4310251159 cites W2587424776 @default.
• W4310251159 cites W2745789124 @default.
• W4310251159 cites W2789050589 @default.
• W4310251159 cites W2791792013 @default.
• W4310251159 cites W2793529478 @default.
• W4310251159 cites W2868238225 @default.
• W4310251159 cites W2886693580 @default.
• W4310251159 cites W2928516672 @default.
• W4310251159 cites W2948946667 @default.
• W4310251159 cites W2955914995 @default.
• W4310251159 cites W2972159390 @default.
• W4310251159 cites W2979002554 @default.
• W4310251159 cites W2980767749 @default.
• W4310251159 cites W3009098406 @default.
• W4310251159 cites W3041365746 @default.
• W4310251159 cites W3108781053 @default.
• W4310251159 cites W4200195180 @default.
• W4310251159 doi "https://doi.org/10.33380/2305-2066-2022-11-4-116-124" @default.
• W4310251159 hasPublicationYear "2022" @default.
• W4310251159 type Work @default.
• W4310251159 citedByCount "0" @default.
• W4310251159 crossrefType "journal-article" @default.
• W4310251159 hasAuthorship W4310251159A5015210539 @default.
• W4310251159 hasAuthorship W4310251159A5055785185 @default.
• W4310251159 hasAuthorship W4310251159A5071816463 @default.
• W4310251159 hasAuthorship W4310251159A5075163362 @default.
• W4310251159 hasAuthorship W4310251159A5080296843 @default.
• W4310251159 hasAuthorship W4310251159A5090941746 @default.
• W4310251159 hasBestOaLocation W43102511591 @default.
• W4310251159 hasConcept C127413603 @default.
• W4310251159 hasConcept C136229726 @default.
• W4310251159 hasConcept C159985019 @default.
• W4310251159 hasConcept C178790620 @default.
• W4310251159 hasConcept C185592680 @default.
• W4310251159 hasConcept C192562407 @default.
• W4310251159 hasConcept C2776964284 @default.
• W4310251159 hasConcept C2778042862 @default.
• W4310251159 hasConcept C2779769944 @default.
• W4310251159 hasConcept C43617362 @default.
• W4310251159 hasConcept C67558686 @default.
• W4310251159 hasConcept C71924100 @default.
• W4310251159 hasConcept C98274493 @default.
• W4310251159 hasConceptScore W4310251159C127413603 @default.
• W4310251159 hasConceptScore W4310251159C136229726 @default.
• W4310251159 hasConceptScore W4310251159C159985019 @default.
• W4310251159 hasConceptScore W4310251159C178790620 @default.
• W4310251159 hasConceptScore W4310251159C185592680 @default.
• W4310251159 hasConceptScore W4310251159C192562407 @default.
• W4310251159 hasConceptScore W4310251159C2776964284 @default.
• W4310251159 hasConceptScore W4310251159C2778042862 @default.
• W4310251159 hasConceptScore W4310251159C2779769944 @default.
• W4310251159 hasConceptScore W4310251159C43617362 @default.
• W4310251159 hasConceptScore W4310251159C67558686 @default.
• W4310251159 hasConceptScore W4310251159C71924100 @default.
• W4310251159 hasConceptScore W4310251159C98274493 @default.
• W4310251159 hasIssue "4" @default.
• W4310251159 hasLocation W43102511591 @default.
• W4310251159 hasOpenAccess W4310251159 @default.
• W4310251159 hasPrimaryLocation W43102511591 @default.
• W4310251159 hasRelatedWork W146596565 @default.
• W4310251159 hasRelatedWork W1993412645 @default.
• W4310251159 hasRelatedWork W1994841349 @default.
• W4310251159 hasRelatedWork W2032328373 @default.
• W4310251159 hasRelatedWork W2109147440 @default.
• W4310251159 hasRelatedWork W2299568583 @default.
• W4310251159 hasRelatedWork W2350895728 @default.
• W4310251159 hasRelatedWork W2494421804 @default.
• W4310251159 hasRelatedWork W2899084033 @default.
• W4310251159 hasRelatedWork W2125717678 @default.
• W4310251159 hasVolume "11" @default.
• W4310251159 isParatext "false" @default.
• W4310251159 isRetracted "false" @default.
• W4310251159 workType "article" @default.