FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310251325> ?p ?o ?g. }

• W4310251325 endingPage "112" @default.
• W4310251325 startingPage "104" @default.
• W4310251325 abstract "ABSTRACT Background We recently showed that by employing an enhanced drug‐delivery approach, repeated administration of glial cell line–derived neurotrophic factor (GDNF) can produce a spatially distributed increased 18 F‐DOPA positron emission tomography (PET) uptake, suggesting sprouting of dopaminergic terminals throughout the putamen structure. Despite this, we failed to prove a significant measurable clinical response. Since, however, we have identified a subject demonstrating a temporal relationship between repeated GDNF infusions and dyskinesia arising in the practically defined off (prac off ) state. Objectives To describe the development of prac off dyskinesia across our study population and consider its utility as an indicator that trophic factor–induced terminal sprouting can affect enhanced endogenous dopamine levels. Methods This was a blinded retrospective analysis of videotaped motor assessments at eight weekly study visits. Dyskinesia in the prac off and supramaximal on state were rated using the Clinical Dyskinesia Rating Scale. Logistic regression was employed to explore the predictors of prac off dyskinesia. Generalized estimated equations were used to estimate the cumulative effect of repeated GDNF infusions. Results Mild–moderate choreiform dyskinesia in the prac off state were seen in 47 assessments in 17 (n = 41) subjects. During the 18‐month timeframe, each subsequent 8‐week period of receiving GDNF increased the risk of demonstrating prac off state dyskinesia by 34% (odds ratio [OR], 1.34 (95% confidence interval [CI], 1.20, 1.50); P < 0.001). An increasing supramaximal on dyskinesia score (OR, 1.17 [95% CI, 1.07, 1.30]; P = 0.001) also increased the likelihood of prac off dyskinesia at that visit. Conclusions We report the first description of increasingly prevalent prac off ‐state dyskinesia developing during the course of a trophic factor study. This may provide a surrogate marker that GDNF can enable recovery of endogenous dopamine release even in advanced Parkinson's disease. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society." @default.
• W4310251325 created "2022-11-30" @default.
• W4310251325 creator A5001902655 @default.
• W4310251325 creator A5007778657 @default.
• W4310251325 creator A5085419072 @default.
• W4310251325 date "2022-11-29" @default.
• W4310251325 modified "2023-09-30" @default.
• W4310251325 title "Practically Defined <i>Off</i>‐State Dyskinesia Following Repeated I<scp>ntra</scp>p<scp>utamenal</scp> Glial Cell Line–Derived Neurotrophic Factor Administration" @default.
• W4310251325 cites W1494864007 @default.
• W4310251325 cites W1903985844 @default.
• W4310251325 cites W1976788622 @default.
• W4310251325 cites W1983721061 @default.
• W4310251325 cites W1990627055 @default.
• W4310251325 cites W1991208841 @default.
• W4310251325 cites W1996001296 @default.
• W4310251325 cites W2016922632 @default.
• W4310251325 cites W2019434097 @default.
• W4310251325 cites W2032138788 @default.
• W4310251325 cites W2032620009 @default.
• W4310251325 cites W2046910164 @default.
• W4310251325 cites W2065197060 @default.
• W4310251325 cites W2069866761 @default.
• W4310251325 cites W2078852929 @default.
• W4310251325 cites W2078966127 @default.
• W4310251325 cites W2082977534 @default.
• W4310251325 cites W2084383513 @default.
• W4310251325 cites W2099816146 @default.
• W4310251325 cites W2103899142 @default.
• W4310251325 cites W2125320763 @default.
• W4310251325 cites W2126499376 @default.
• W4310251325 cites W2138462240 @default.
• W4310251325 cites W2145568285 @default.
• W4310251325 cites W2149731696 @default.
• W4310251325 cites W2163987873 @default.
• W4310251325 cites W2165526364 @default.
• W4310251325 cites W2334461448 @default.
• W4310251325 cites W2521337760 @default.
• W4310251325 cites W2916149712 @default.
• W4310251325 cites W2917018165 @default.
• W4310251325 cites W2998465745 @default.
• W4310251325 cites W3012801913 @default.
• W4310251325 cites W3155810498 @default.
• W4310251325 cites W4206188376 @default.
• W4310251325 doi "https://doi.org/10.1002/mds.29262" @default.
• W4310251325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36444971" @default.
• W4310251325 hasPublicationYear "2022" @default.
• W4310251325 type Work @default.
• W4310251325 citedByCount "2" @default.
• W4310251325 countsByYear W43102513252023 @default.
• W4310251325 crossrefType "journal-article" @default.
• W4310251325 hasAuthorship W4310251325A5001902655 @default.
• W4310251325 hasAuthorship W4310251325A5007778657 @default.
• W4310251325 hasAuthorship W4310251325A5085419072 @default.
• W4310251325 hasBestOaLocation W43102513251 @default.
• W4310251325 hasConcept C126322002 @default.
• W4310251325 hasConcept C137183658 @default.
• W4310251325 hasConcept C156957248 @default.
• W4310251325 hasConcept C15744967 @default.
• W4310251325 hasConcept C160539049 @default.
• W4310251325 hasConcept C169760540 @default.
• W4310251325 hasConcept C170493617 @default.
• W4310251325 hasConcept C185856081 @default.
• W4310251325 hasConcept C2779134260 @default.
• W4310251325 hasConcept C2779734285 @default.
• W4310251325 hasConcept C2780405171 @default.
• W4310251325 hasConcept C42219234 @default.
• W4310251325 hasConcept C44249647 @default.
• W4310251325 hasConcept C513476851 @default.
• W4310251325 hasConcept C71924100 @default.
• W4310251325 hasConceptScore W4310251325C126322002 @default.
• W4310251325 hasConceptScore W4310251325C137183658 @default.
• W4310251325 hasConceptScore W4310251325C156957248 @default.
• W4310251325 hasConceptScore W4310251325C15744967 @default.
• W4310251325 hasConceptScore W4310251325C160539049 @default.
• W4310251325 hasConceptScore W4310251325C169760540 @default.
• W4310251325 hasConceptScore W4310251325C170493617 @default.
• W4310251325 hasConceptScore W4310251325C185856081 @default.
• W4310251325 hasConceptScore W4310251325C2779134260 @default.
• W4310251325 hasConceptScore W4310251325C2779734285 @default.
• W4310251325 hasConceptScore W4310251325C2780405171 @default.
• W4310251325 hasConceptScore W4310251325C42219234 @default.
• W4310251325 hasConceptScore W4310251325C44249647 @default.
• W4310251325 hasConceptScore W4310251325C513476851 @default.
• W4310251325 hasConceptScore W4310251325C71924100 @default.
• W4310251325 hasIssue "1" @default.
• W4310251325 hasLocation W43102513251 @default.
• W4310251325 hasLocation W43102513252 @default.
• W4310251325 hasLocation W43102513253 @default.
• W4310251325 hasLocation W43102513254 @default.
• W4310251325 hasOpenAccess W4310251325 @default.
• W4310251325 hasPrimaryLocation W43102513251 @default.
• W4310251325 hasRelatedWork W1989558097 @default.
• W4310251325 hasRelatedWork W2035687277 @default.
• W4310251325 hasRelatedWork W2056184820 @default.
• W4310251325 hasRelatedWork W2065978481 @default.
• W4310251325 hasRelatedWork W2079922268 @default.
• W4310251325 hasRelatedWork W2083776533 @default.
• W4310251325 hasRelatedWork W2359508854 @default.

• next