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• W4310256546 endingPage "122444" @default.
• W4310256546 startingPage "122444" @default.
• W4310256546 abstract "Due to the possibility of designing various spatial structures, three-dimensional printing can be implemented in the production of customized medicines. Nevertheless, the use of these methods for the production of dosage forms requires further optimization, understanding, and development of printouts' quality verification mechanisms. Therefore, the goal of our work was the preparation and advanced characterization of 3D printed orodispersible tablets (ODTs) containing fluconazole, printed by the fused deposition modeling (FDM) method. We prepared and analyzed 7 printable filaments containing from 10% to 70% fluconazole, used as model API. Obtaining a FDM-printable filament with such a high API content makes our work unique. In addition, we confirmed the 12-month stability of the formulation, which, to our knowledge, is the first study of this type. Next, we printed 10 series of porous tablets containing 50 mg of API from both fresh and stored filaments containing 20 %, 40 %, or 70 % fluconazole. We confirmed the high quality and precision of the printouts using scanning electron microscopy. The detailed analysis of the tablets' disintegration process included the Pharmacopeial test, but also the surface dissolution imaging analysis (SDI) and the test simulating oral conditions performed in own-constructed apparatus. For each composition, we obtained tablets disintegrating in less than 3 min, i.e., meeting the criteria for ODTs required by the European Pharmacopeia. The filaments' storage at ambient conditions did not affect the quality of the tablets. All printed tablets released over 95% of the fluconazole within 30 min. Moreover, the printouts were stable for two weeks." @default.
• W4310256546 created "2022-11-30" @default.
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• W4310256546 date "2023-01-01" @default.
• W4310256546 modified "2023-10-01" @default.
• W4310256546 title "Preparation and advanced characterization of highly drug-loaded, 3D printed orodispersible tablets containing fluconazole" @default.
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• W4310256546 doi "https://doi.org/10.1016/j.ijpharm.2022.122444" @default.
• W4310256546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36503848" @default.
• W4310256546 hasPublicationYear "2023" @default.
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