FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310258370> ?p ?o ?g. }

• W4310258370 endingPage "44" @default.
• W4310258370 startingPage "37" @default.
• W4310258370 abstract "The diagnostic value of intestinal fatty acid-binding protein (I-FABP) as a potential marker for small intestinal mucosal integrity has been studied in recent years. This cytoplasmic protein in enterocytes transports fatty acids to the site of lipid synthesis in the endoplasmic reticulum from the apical membrane of the enterocyte. The purpose of the research was to evaluate the level of I-FABP in children with autism spectrum disorders (ASD) depending on the adherence to a gluten-free diet (GFD) and comped to the healthy peers. Research materials and methods: a single-center, prospective, observational, continuous, controlled study of 230 children aged 3 to 15 y/o was conducted in 2019 - 2020. Group 1 included 36 children with ASD who had been on fasting for more than 6 months: 23 (64%) boys/13 (36%) girls. 49 patients with ASD without dietary restrictions made up the Group 2: 35 (71%) boys/14 (29%) girls. The [control] Group 3 included 145 apparently healthy children: 83 (57.3%) boys/62 (42.7%) girls. The patients’ median age in Group 1 was 6.5 [4.0; 8.0] y/o, 6.0 [4.0; 7.0] y/o in G2, and 8.0 [6.0; 11.0] y/o in G3, with the differences being statistically significant (p=0.0001). I-FABP was determined in blood serum by enzyme-linked immunosorbent assay using “Human Casomorphin” and “Human I-FABP” reagent kits (ELISA Kit by “Hycult Biotech, Inc.” Netherlands, with the determination error = 3.2%, 100% method sensitivity, 85% specificity). Results: the median level of I-FABP in blood serum in children with ASD on GFD was statistically significantly (5.6 times) lower compared to children who did not comply with GFD (107.4 [92.70; 197.20] pg/ml and 601 [295.7; 715.3] pg/ml) and 5.1 times lower than the level in the control group (107.4 [92.70; 197.20] pg/ml and 543.80 [388.0; 750.0] pg/ml) (p<0.001). There were no statistically significant differences in I-FABP levels between children in the control group and patients with ASD who did not use diet therapy (p=0.369). There was no statistically significant correlation found - in all groups - between the level of I-FABP and the patients’ age. Conclusion: the obtained results confirm the hypothesis of increased intestinal permeability in children with autism, which may be pathogenetically significant for some patients with ASD, and this must be taken into account in a personalized approach to prescribing the diet therapy. The GFD for children with ASD helps reducing the damage to the small intestine if are having gluten sensitivity." @default.
• W4310258370 created "2022-11-30" @default.
• W4310258370 creator A5039838674 @default.
• W4310258370 creator A5051940137 @default.
• W4310258370 creator A5080711007 @default.
• W4310258370 creator A5083249659 @default.
• W4310258370 date "2022-12-16" @default.
• W4310258370 modified "2023-10-16" @default.
• W4310258370 title "INTESTINAL FATTY ACID-BINDING PROTEIN AS A MARKER FOR THE SMALL INTESTINE CONDITION IN CHILDREN WITH AUTISM" @default.
• W4310258370 doi "https://doi.org/10.24110/0031-403x-2022-101-6-37-44" @default.
• W4310258370 hasPublicationYear "2022" @default.
• W4310258370 type Work @default.
• W4310258370 citedByCount "0" @default.
• W4310258370 crossrefType "journal-article" @default.
• W4310258370 hasAuthorship W4310258370A5039838674 @default.
• W4310258370 hasAuthorship W4310258370A5051940137 @default.
• W4310258370 hasAuthorship W4310258370A5080711007 @default.
• W4310258370 hasAuthorship W4310258370A5083249659 @default.
• W4310258370 hasConcept C104317684 @default.
• W4310258370 hasConcept C118552586 @default.
• W4310258370 hasConcept C126322002 @default.
• W4310258370 hasConcept C134018914 @default.
• W4310258370 hasConcept C205778803 @default.
• W4310258370 hasConcept C2776834966 @default.
• W4310258370 hasConcept C2777882243 @default.
• W4310258370 hasConcept C2778538070 @default.
• W4310258370 hasConcept C2779604457 @default.
• W4310258370 hasConcept C543025807 @default.
• W4310258370 hasConcept C55493867 @default.
• W4310258370 hasConcept C71924100 @default.
• W4310258370 hasConcept C86803240 @default.
• W4310258370 hasConcept C90924648 @default.
• W4310258370 hasConceptScore W4310258370C104317684 @default.
• W4310258370 hasConceptScore W4310258370C118552586 @default.
• W4310258370 hasConceptScore W4310258370C126322002 @default.
• W4310258370 hasConceptScore W4310258370C134018914 @default.
• W4310258370 hasConceptScore W4310258370C205778803 @default.
• W4310258370 hasConceptScore W4310258370C2776834966 @default.
• W4310258370 hasConceptScore W4310258370C2777882243 @default.
• W4310258370 hasConceptScore W4310258370C2778538070 @default.
• W4310258370 hasConceptScore W4310258370C2779604457 @default.
• W4310258370 hasConceptScore W4310258370C543025807 @default.
• W4310258370 hasConceptScore W4310258370C55493867 @default.
• W4310258370 hasConceptScore W4310258370C71924100 @default.
• W4310258370 hasConceptScore W4310258370C86803240 @default.
• W4310258370 hasConceptScore W4310258370C90924648 @default.
• W4310258370 hasIssue "6" @default.
• W4310258370 hasLocation W43102583701 @default.
• W4310258370 hasOpenAccess W4310258370 @default.
• W4310258370 hasPrimaryLocation W43102583701 @default.
• W4310258370 hasRelatedWork W1976747158 @default.
• W4310258370 hasRelatedWork W1995654982 @default.
• W4310258370 hasRelatedWork W2005042805 @default.
• W4310258370 hasRelatedWork W2019374231 @default.
• W4310258370 hasRelatedWork W2060643724 @default.
• W4310258370 hasRelatedWork W2102326852 @default.
• W4310258370 hasRelatedWork W2143051201 @default.
• W4310258370 hasRelatedWork W2154264779 @default.
• W4310258370 hasRelatedWork W2417190956 @default.
• W4310258370 hasRelatedWork W3031513826 @default.
• W4310258370 hasVolume "101" @default.
• W4310258370 isParatext "false" @default.
• W4310258370 isRetracted "false" @default.
• W4310258370 workType "article" @default.