Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310258983> ?p ?o ?g. }
- W4310258983 endingPage "1518" @default.
- W4310258983 startingPage "1507" @default.
- W4310258983 abstract "Abstract Obesity is a high‐risk factor in the development of endometrial cancer (EC). Our previous study observed that miR‐548ag was significantly overexpressed in the sera of obese individuals. Here, we report the function of miR‐548ag and its mechanism in promoting the obesity‐related progression of EC. The content of miR‐548ag was increased in the serum of obese EC individuals. Bioinformatics analysis indicated that the survival rate of EC patients with a higher expression of miR‐548ag was significantly reduced. The Mps One Binder Kinase Activator 1B ( MOB1B , the core member of the Hippo signaling pathway) is a direct target gene of miR‐548ag, which is inversely correlated with the expression of miR‐548ag. The overexpression of miR‐548ag enhances the proliferation, invasion, and migration, and inhibits apoptosis by downregulating the expression of MOB1B, leading to the deactivation of the Hippo pathway in EC cell lines and contributing to tumor progression in vivo. Our study has established that miR‐548ag functions as an oncogene by suppressing MOB1B in the development of obesity‐related EC." @default.
- W4310258983 created "2022-11-30" @default.
- W4310258983 creator A5006946866 @default.
- W4310258983 creator A5011891513 @default.
- W4310258983 creator A5014504120 @default.
- W4310258983 creator A5021768279 @default.
- W4310258983 creator A5023909286 @default.
- W4310258983 creator A5032821174 @default.
- W4310258983 creator A5032997576 @default.
- W4310258983 creator A5045758475 @default.
- W4310258983 creator A5075257508 @default.
- W4310258983 creator A5084747070 @default.
- W4310258983 creator A5085352453 @default.
- W4310258983 creator A5088275242 @default.
- W4310258983 date "2022-12-23" @default.
- W4310258983 modified "2023-10-14" @default.
- W4310258983 title "<scp>miR</scp>‐548ag functions as an oncogene by suppressing <scp>MOB1B</scp> in the development of obesity‐related endometrial cancer" @default.
- W4310258983 cites W2057217096 @default.
- W4310258983 cites W2070196278 @default.
- W4310258983 cites W2117977572 @default.
- W4310258983 cites W2134629862 @default.
- W4310258983 cites W2160904849 @default.
- W4310258983 cites W2162674813 @default.
- W4310258983 cites W2225462341 @default.
- W4310258983 cites W2271267346 @default.
- W4310258983 cites W2275678839 @default.
- W4310258983 cites W2560287982 @default.
- W4310258983 cites W2588025094 @default.
- W4310258983 cites W2588757737 @default.
- W4310258983 cites W2899402692 @default.
- W4310258983 cites W2901168016 @default.
- W4310258983 cites W2904686713 @default.
- W4310258983 cites W2913699457 @default.
- W4310258983 cites W2951302199 @default.
- W4310258983 cites W2970358232 @default.
- W4310258983 cites W2979184404 @default.
- W4310258983 cites W2981310644 @default.
- W4310258983 cites W2982627325 @default.
- W4310258983 cites W3001803802 @default.
- W4310258983 cites W3006318294 @default.
- W4310258983 cites W3009137910 @default.
- W4310258983 cites W3097540111 @default.
- W4310258983 cites W3126734014 @default.
- W4310258983 cites W3128646645 @default.
- W4310258983 cites W3152789244 @default.
- W4310258983 cites W3162350134 @default.
- W4310258983 cites W4210989197 @default.
- W4310258983 cites W4310258983 @default.
- W4310258983 doi "https://doi.org/10.1111/cas.15679" @default.
- W4310258983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36445107" @default.
- W4310258983 hasPublicationYear "2022" @default.
- W4310258983 type Work @default.
- W4310258983 citedByCount "2" @default.
- W4310258983 countsByYear W43102589832022 @default.
- W4310258983 countsByYear W43102589832023 @default.
- W4310258983 crossrefType "journal-article" @default.
- W4310258983 hasAuthorship W4310258983A5006946866 @default.
- W4310258983 hasAuthorship W4310258983A5011891513 @default.
- W4310258983 hasAuthorship W4310258983A5014504120 @default.
- W4310258983 hasAuthorship W4310258983A5021768279 @default.
- W4310258983 hasAuthorship W4310258983A5023909286 @default.
- W4310258983 hasAuthorship W4310258983A5032821174 @default.
- W4310258983 hasAuthorship W4310258983A5032997576 @default.
- W4310258983 hasAuthorship W4310258983A5045758475 @default.
- W4310258983 hasAuthorship W4310258983A5075257508 @default.
- W4310258983 hasAuthorship W4310258983A5084747070 @default.
- W4310258983 hasAuthorship W4310258983A5085352453 @default.
- W4310258983 hasAuthorship W4310258983A5088275242 @default.
- W4310258983 hasBestOaLocation W43102589831 @default.
- W4310258983 hasConcept C121608353 @default.
- W4310258983 hasConcept C126322002 @default.
- W4310258983 hasConcept C134018914 @default.
- W4310258983 hasConcept C170493617 @default.
- W4310258983 hasConcept C172512520 @default.
- W4310258983 hasConcept C190283241 @default.
- W4310258983 hasConcept C2777088508 @default.
- W4310258983 hasConcept C2781018059 @default.
- W4310258983 hasConcept C29537977 @default.
- W4310258983 hasConcept C502942594 @default.
- W4310258983 hasConcept C54355233 @default.
- W4310258983 hasConcept C62112901 @default.
- W4310258983 hasConcept C71924100 @default.
- W4310258983 hasConcept C86803240 @default.
- W4310258983 hasConcept C88045685 @default.
- W4310258983 hasConceptScore W4310258983C121608353 @default.
- W4310258983 hasConceptScore W4310258983C126322002 @default.
- W4310258983 hasConceptScore W4310258983C134018914 @default.
- W4310258983 hasConceptScore W4310258983C170493617 @default.
- W4310258983 hasConceptScore W4310258983C172512520 @default.
- W4310258983 hasConceptScore W4310258983C190283241 @default.
- W4310258983 hasConceptScore W4310258983C2777088508 @default.
- W4310258983 hasConceptScore W4310258983C2781018059 @default.
- W4310258983 hasConceptScore W4310258983C29537977 @default.
- W4310258983 hasConceptScore W4310258983C502942594 @default.
- W4310258983 hasConceptScore W4310258983C54355233 @default.
- W4310258983 hasConceptScore W4310258983C62112901 @default.
- W4310258983 hasConceptScore W4310258983C71924100 @default.
- W4310258983 hasConceptScore W4310258983C86803240 @default.