Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310262021> ?p ?o ?g. }
- W4310262021 abstract "Iron as an essential element, is involved in various cellular functions and maintaining cell viability, cancer cell is more dependent on iron than normal cell due to its chief characteristic of hyper-proliferation. Despite that some of the iron chelators exhibited potent and broad antitumor activity, severe systemic toxicities have limited their clinical application. Polyaminoacids, as both drug-delivery platform and therapeutic agents, have attracted great interests owing to their different medical applications and biocompatibility. Herein, we have developed a novel iron nanochelator PL-DFX, which composed of deferasirox and hyperbranched polylysine. PL-DFX has higher cytotoxicity than DFX and this effect can be partially reversed by Fe 2+ supplementation. PL-DFX also inhibited migration and invasion of cancer cells, interfere with iron metabolism, induce phase G1/S arrest and depolarize mitochondria membrane potential. Additionally, the anti-tumor potency of PL-DFX was also supported by organoids derived from clinical specimens. In this study, DFX-based iron nanochelator has provided a promising and prospective strategy for cancer therapy via iron metabolism disruption." @default.
- W4310262021 created "2022-11-30" @default.
- W4310262021 creator A5002487860 @default.
- W4310262021 creator A5002689488 @default.
- W4310262021 creator A5018814025 @default.
- W4310262021 creator A5030863883 @default.
- W4310262021 creator A5037117630 @default.
- W4310262021 creator A5043645575 @default.
- W4310262021 creator A5055218910 @default.
- W4310262021 creator A5060531768 @default.
- W4310262021 creator A5062513081 @default.
- W4310262021 creator A5080379153 @default.
- W4310262021 date "2022-11-28" @default.
- W4310262021 modified "2023-09-26" @default.
- W4310262021 title "A DFX-based iron nanochelator for cancer therapy" @default.
- W4310262021 cites W146649955 @default.
- W4310262021 cites W1549746240 @default.
- W4310262021 cites W1575278276 @default.
- W4310262021 cites W1579189600 @default.
- W4310262021 cites W1828001156 @default.
- W4310262021 cites W1965618865 @default.
- W4310262021 cites W1975497763 @default.
- W4310262021 cites W2026288205 @default.
- W4310262021 cites W2036148514 @default.
- W4310262021 cites W2037305111 @default.
- W4310262021 cites W2041164141 @default.
- W4310262021 cites W2043398720 @default.
- W4310262021 cites W2050772120 @default.
- W4310262021 cites W2062107099 @default.
- W4310262021 cites W2062638143 @default.
- W4310262021 cites W2075973291 @default.
- W4310262021 cites W2091068055 @default.
- W4310262021 cites W2091336659 @default.
- W4310262021 cites W2121242732 @default.
- W4310262021 cites W2135913853 @default.
- W4310262021 cites W2144576921 @default.
- W4310262021 cites W2145638787 @default.
- W4310262021 cites W2157872347 @default.
- W4310262021 cites W2159178548 @default.
- W4310262021 cites W2295373901 @default.
- W4310262021 cites W2331190804 @default.
- W4310262021 cites W2508132062 @default.
- W4310262021 cites W2559410759 @default.
- W4310262021 cites W2790601563 @default.
- W4310262021 cites W2799444748 @default.
- W4310262021 cites W2802630573 @default.
- W4310262021 cites W2885503857 @default.
- W4310262021 cites W2888091897 @default.
- W4310262021 cites W2900793043 @default.
- W4310262021 cites W2981090081 @default.
- W4310262021 cites W3043991886 @default.
- W4310262021 cites W3047763065 @default.
- W4310262021 cites W3165369090 @default.
- W4310262021 cites W3175730700 @default.
- W4310262021 cites W3184791276 @default.
- W4310262021 cites W3205520228 @default.
- W4310262021 cites W4200483722 @default.
- W4310262021 cites W4206717653 @default.
- W4310262021 cites W4220744626 @default.
- W4310262021 cites W4281982640 @default.
- W4310262021 doi "https://doi.org/10.3389/fbioe.2022.1078137" @default.
- W4310262021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36518196" @default.
- W4310262021 hasPublicationYear "2022" @default.
- W4310262021 type Work @default.
- W4310262021 citedByCount "0" @default.
- W4310262021 crossrefType "journal-article" @default.
- W4310262021 hasAuthorship W4310262021A5002487860 @default.
- W4310262021 hasAuthorship W4310262021A5002689488 @default.
- W4310262021 hasAuthorship W4310262021A5018814025 @default.
- W4310262021 hasAuthorship W4310262021A5030863883 @default.
- W4310262021 hasAuthorship W4310262021A5037117630 @default.
- W4310262021 hasAuthorship W4310262021A5043645575 @default.
- W4310262021 hasAuthorship W4310262021A5055218910 @default.
- W4310262021 hasAuthorship W4310262021A5060531768 @default.
- W4310262021 hasAuthorship W4310262021A5062513081 @default.
- W4310262021 hasAuthorship W4310262021A5080379153 @default.
- W4310262021 hasBestOaLocation W43102620211 @default.
- W4310262021 hasConcept C109316439 @default.
- W4310262021 hasConcept C121608353 @default.
- W4310262021 hasConcept C126322002 @default.
- W4310262021 hasConcept C1491633281 @default.
- W4310262021 hasConcept C178790620 @default.
- W4310262021 hasConcept C185592680 @default.
- W4310262021 hasConcept C202751555 @default.
- W4310262021 hasConcept C2776672577 @default.
- W4310262021 hasConcept C2777230088 @default.
- W4310262021 hasConcept C2777799968 @default.
- W4310262021 hasConcept C2781053155 @default.
- W4310262021 hasConcept C502942594 @default.
- W4310262021 hasConcept C53227056 @default.
- W4310262021 hasConcept C55493867 @default.
- W4310262021 hasConcept C62112901 @default.
- W4310262021 hasConcept C71924100 @default.
- W4310262021 hasConcept C86803240 @default.
- W4310262021 hasConcept C96232424 @default.
- W4310262021 hasConcept C98274493 @default.
- W4310262021 hasConceptScore W4310262021C109316439 @default.
- W4310262021 hasConceptScore W4310262021C121608353 @default.
- W4310262021 hasConceptScore W4310262021C126322002 @default.
- W4310262021 hasConceptScore W4310262021C1491633281 @default.