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- W4310263609 abstract "Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of OGN, encoding osteoglycin, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. OGN was also differentially expressed in fibroblasts isolated from patients with ALS. OGN transcript was present at lower levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS." @default.
- W4310263609 created "2022-11-30" @default.
- W4310263609 creator A5024900493 @default.
- W4310263609 date "2022-11-27" @default.
- W4310263609 modified "2023-09-23" @default.
- W4310263609 title "Differential expression of OGN in amyotrophic lateral sclerosis." @default.
- W4310263609 doi "https://doi.org/10.31219/osf.io/w3adk" @default.
- W4310263609 hasPublicationYear "2022" @default.
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