Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310263722> ?p ?o ?g. }
- W4310263722 endingPage "146" @default.
- W4310263722 startingPage "133" @default.
- W4310263722 abstract "Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and represents a heterogeneous entity. One‐third of DLBCL arises from extranodal organs and its prognosis often varies with regard to the sites involved. Molecular features are important to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Extranodal DLBCLs originated from the breast, skin, uterus, immune‐privileged sites such as the central nervous system and testes, often show a high proportion of non‐germinal center B‐cell‐like (non‐GCB) phenotypes, with a high frequency of MYD88 / CD79B mutations. In contrast, extranodal DLBCLs originated from the thyroid gland and stomach show a relatively low proportion of non‐GCB phenotype, with a considerably excellent prognosis. Immunochemotherapy with rituximab is the standard of care in both nodal and extranodal DLBCLs. However, approximately 40% of the patients experience treatment failure. It is critical to optimize the treatment strategy, including radiotherapy, autologous stem cell transplantation and targeted therapy according to the clinical characteristics and molecular heterogeneity. In this review, we present an overview of the key molecular pathways, prognosis assessment and innovative therapies in primary extranodal DLBCLs." @default.
- W4310263722 created "2022-11-30" @default.
- W4310263722 creator A5021146920 @default.
- W4310263722 creator A5045752884 @default.
- W4310263722 creator A5054957223 @default.
- W4310263722 creator A5081645649 @default.
- W4310263722 date "2022-09-01" @default.
- W4310263722 modified "2023-10-14" @default.
- W4310263722 title "Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis" @default.
- W4310263722 cites W1203878641 @default.
- W4310263722 cites W1505869554 @default.
- W4310263722 cites W1522525997 @default.
- W4310263722 cites W1904207926 @default.
- W4310263722 cites W1949176581 @default.
- W4310263722 cites W1953677527 @default.
- W4310263722 cites W1955256573 @default.
- W4310263722 cites W1968179560 @default.
- W4310263722 cites W1969414253 @default.
- W4310263722 cites W1976564639 @default.
- W4310263722 cites W1976864824 @default.
- W4310263722 cites W1979816280 @default.
- W4310263722 cites W1982415758 @default.
- W4310263722 cites W1989124191 @default.
- W4310263722 cites W1989527317 @default.
- W4310263722 cites W1991490502 @default.
- W4310263722 cites W2008815830 @default.
- W4310263722 cites W2009770007 @default.
- W4310263722 cites W2012666377 @default.
- W4310263722 cites W2025506316 @default.
- W4310263722 cites W2027801317 @default.
- W4310263722 cites W2030187051 @default.
- W4310263722 cites W2030285098 @default.
- W4310263722 cites W2030736011 @default.
- W4310263722 cites W2034562048 @default.
- W4310263722 cites W2035387470 @default.
- W4310263722 cites W2042484101 @default.
- W4310263722 cites W2047185936 @default.
- W4310263722 cites W2054538838 @default.
- W4310263722 cites W2055496797 @default.
- W4310263722 cites W2057870128 @default.
- W4310263722 cites W2059762808 @default.
- W4310263722 cites W2060254656 @default.
- W4310263722 cites W2060615421 @default.
- W4310263722 cites W2062683665 @default.
- W4310263722 cites W2065160134 @default.
- W4310263722 cites W2068878719 @default.
- W4310263722 cites W2076889483 @default.
- W4310263722 cites W2082984406 @default.
- W4310263722 cites W2087083130 @default.
- W4310263722 cites W2096160655 @default.
- W4310263722 cites W2096984838 @default.
- W4310263722 cites W2100367991 @default.
- W4310263722 cites W2100646692 @default.
- W4310263722 cites W2102720176 @default.
- W4310263722 cites W2103716188 @default.
- W4310263722 cites W2105433412 @default.
- W4310263722 cites W2111960004 @default.
- W4310263722 cites W2112325849 @default.
- W4310263722 cites W2116382435 @default.
- W4310263722 cites W2117692326 @default.
- W4310263722 cites W2118192033 @default.
- W4310263722 cites W2119178992 @default.
- W4310263722 cites W2119651556 @default.
- W4310263722 cites W2120104264 @default.
- W4310263722 cites W2121563697 @default.
- W4310263722 cites W2129623766 @default.
- W4310263722 cites W2129769331 @default.
- W4310263722 cites W2129822063 @default.
- W4310263722 cites W2129831897 @default.
- W4310263722 cites W2132115413 @default.
- W4310263722 cites W2137581187 @default.
- W4310263722 cites W2138428575 @default.
- W4310263722 cites W2142109384 @default.
- W4310263722 cites W2145320728 @default.
- W4310263722 cites W2147246240 @default.
- W4310263722 cites W2148071277 @default.
- W4310263722 cites W2155376820 @default.
- W4310263722 cites W2166223128 @default.
- W4310263722 cites W2194676014 @default.
- W4310263722 cites W2197237426 @default.
- W4310263722 cites W2233049419 @default.
- W4310263722 cites W2264682687 @default.
- W4310263722 cites W2301170762 @default.
- W4310263722 cites W2303343204 @default.
- W4310263722 cites W2307797992 @default.
- W4310263722 cites W2332942389 @default.
- W4310263722 cites W2346651667 @default.
- W4310263722 cites W2410428304 @default.
- W4310263722 cites W2428381774 @default.
- W4310263722 cites W2462981464 @default.
- W4310263722 cites W2474059146 @default.
- W4310263722 cites W2490611318 @default.
- W4310263722 cites W2523990469 @default.
- W4310263722 cites W2525561810 @default.
- W4310263722 cites W2531432151 @default.
- W4310263722 cites W2536954905 @default.
- W4310263722 cites W2540476040 @default.
- W4310263722 cites W2574668635 @default.