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- W4310264501 abstract "Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of SLC38A1, encoding solute carrier family 38 member 1, in iPSC-derived motor neurons of patients with ALS. SLC38A1 was also differentially expressed in the skeletal muscle of patients with ALS. SLC38A1 transcript was present at significantly higher levels in ALS iPSC-derived motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS." @default.
- W4310264501 created "2022-11-30" @default.
- W4310264501 creator A5024900493 @default.
- W4310264501 date "2022-11-27" @default.
- W4310264501 modified "2023-09-27" @default.
- W4310264501 title "Differential expression of SLC38A1 in amyotrophic lateral sclerosis." @default.
- W4310264501 doi "https://doi.org/10.31219/osf.io/2a8u7" @default.
- W4310264501 hasPublicationYear "2022" @default.
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