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- W4310273260 abstract "Abstract Longitudinal studies have revealed large interindividual differences in antibody responses induced by SARS-CoV-2 mRNA vaccines. Thus, we performed a comprehensive analysis of adaptive immune responses induced by three doses of the BNT162b2 SARS-CoV-2 mRNA vaccines. The responses of spike-specific CD4 + T cells, CD8 + T cells and serum IgG, and the serum neutralization capacities induced by the two vaccines declined 6 months later. The 3 rd dose increased serum spike IgG and neutralizing capacities against the wild-type and Omicron spikes to higher levels than the 2 nd dose, and this was supported by memory B cell responses, which gradually increased after the 2 nd dose and were further enhanced by the 3 rd dose. The 3 rd dose moderately increased the frequencies of spike-specific CD4 + T cells, but the frequencies of spike-specific CD8 + T cells remained unchanged. T cells reactive against the Omicron spike were 1.3-fold fewer than those against the wild-type spike. The early responsiveness of spike-specific CD4 + T, circulating T follicular helper cells and circulating T peripheral helper cells correlated with memory B cell responses to the booster vaccination, and early spike-specific CD4 + T cell responses were also associated with spike-specific CD8 + T cell responses. These findings highlight the importance of evaluating cellular responses to optimize future vaccine strategies." @default.
- W4310273260 created "2022-11-30" @default.
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- W4310273260 date "2022-11-27" @default.
- W4310273260 modified "2023-10-01" @default.
- W4310273260 title "Early CD4+ T cell responses induced by the BNT162b2 SARS-CoV-2 mRNA vaccine predict immunological memory" @default.
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- W4310273260 doi "https://doi.org/10.1038/s41598-022-24938-4" @default.
- W4310273260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36437407" @default.
- W4310273260 hasPublicationYear "2022" @default.
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