FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310275976> ?p ?o ?g. }

• W4310275976 endingPage "62" @default.
• W4310275976 startingPage "51" @default.
• W4310275976 abstract "The combination of rosuvastatin and ezetimibe has promising clinical benefits with a significant safety and tolerability profile. However, there is a lack of clinical data supporting the drug-drug interaction (DDI) in Chinese population. Thus, the aim of this study is to assess the potential pharmacokinetic DDI between rosuvastatin and ezetimibe in a Chinese population.In this randomized, open-label, phase 1 study, 12 healthy volunteers were randomized to three treatment groups: 10 mg rosuvastatin plus 10 mg ezetimibe, 10 mg rosuvastatin alone, and 10 mg ezetimibe alone under fasting conditions. The plasma concentrations of rosuvastatin and ezetimibe were determined, and the pharmacokinetic parameters were calculated. Primary endpoints were peak plasma concentration (Cmax), area under the curve from zero to last measurement (AUC0-t), and area under the curve from zero to infinity (AUC0-∞) that were log-transformed, and co-administration was compared with monotherapy to evaluate the DDI.The geometric mean ratios (GMRs) of rosuvastatin with 90% confidence intervals (CIs) were 0.94 (0.80-1.12) for Cmax, 0.96 (0.85-1.08) for AUC0-t, and 0.96 (0.86-1.07) for AUC0-∞ when administered in combination with ezetimibe versus administered alone. The GMRs of unconjugated ezetimibe and total ezetimibe with 90% CIs were 1.15 (1.00-1.32) and 0.93 (0.80-1.07) for Cmax, 0.96 (0.84-1.10) and 0.95 (0.83-1.08) for AUC0-t, and 1.06 (0.96-1.18) and 0.94 (0.80-1.11) for AUC0-∞, respectively, when administered in combination with rosuvastatin versus administered alone.Co-administration of rosuvastatin and ezetimibe showed no clinically significant pharmacokinetic interactions in a healthy Chinese population." @default.
• W4310275976 created "2022-11-30" @default.
• W4310275976 creator A5015513363 @default.
• W4310275976 creator A5016714350 @default.
• W4310275976 creator A5022495891 @default.
• W4310275976 creator A5022607762 @default.
• W4310275976 creator A5029484872 @default.
• W4310275976 creator A5044777415 @default.
• W4310275976 creator A5045584394 @default.
• W4310275976 creator A5046225712 @default.
• W4310275976 creator A5053815236 @default.
• W4310275976 creator A5070732604 @default.
• W4310275976 creator A5076075970 @default.
• W4310275976 creator A5081322419 @default.
• W4310275976 creator A5086533374 @default.
• W4310275976 creator A5091683676 @default.
• W4310275976 date "2022-11-27" @default.
• W4310275976 modified "2023-10-08" @default.
• W4310275976 title "Pharmacokinetic Interactions and Tolerability of Rosuvastatin and Ezetimibe: A Randomized, Phase 1, Crossover Study in Healthy Chinese Participants" @default.
• W4310275976 cites W1972054549 @default.
• W4310275976 cites W1985258577 @default.
• W4310275976 cites W1992084132 @default.
• W4310275976 cites W2014204362 @default.
• W4310275976 cites W2022507089 @default.
• W4310275976 cites W2033048555 @default.
• W4310275976 cites W2038017837 @default.
• W4310275976 cites W2039944972 @default.
• W4310275976 cites W2042818572 @default.
• W4310275976 cites W2046057128 @default.
• W4310275976 cites W2066135509 @default.
• W4310275976 cites W2074721596 @default.
• W4310275976 cites W2076224130 @default.
• W4310275976 cites W2078746376 @default.
• W4310275976 cites W2087494447 @default.
• W4310275976 cites W2088531744 @default.
• W4310275976 cites W2105570905 @default.
• W4310275976 cites W2107307116 @default.
• W4310275976 cites W2109972098 @default.
• W4310275976 cites W2117592927 @default.
• W4310275976 cites W2124742375 @default.
• W4310275976 cites W2135961993 @default.
• W4310275976 cites W2148027220 @default.
• W4310275976 cites W2151332328 @default.
• W4310275976 cites W2154704322 @default.
• W4310275976 cites W2163576192 @default.
• W4310275976 cites W2291969078 @default.
• W4310275976 cites W2469492348 @default.
• W4310275976 cites W2583862987 @default.
• W4310275976 cites W2604472673 @default.
• W4310275976 cites W2743233925 @default.
• W4310275976 cites W2768983741 @default.
• W4310275976 cites W2775439948 @default.
• W4310275976 cites W2796626909 @default.
• W4310275976 cites W2804780808 @default.
• W4310275976 cites W2900034165 @default.
• W4310275976 cites W2953804067 @default.
• W4310275976 cites W3005281313 @default.
• W4310275976 cites W3014266238 @default.
• W4310275976 cites W3033098422 @default.
• W4310275976 cites W3129818723 @default.
• W4310275976 cites W3183857127 @default.
• W4310275976 doi "https://doi.org/10.1007/s13318-022-00798-1" @default.
• W4310275976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36437383" @default.
• W4310275976 hasPublicationYear "2022" @default.
• W4310275976 type Work @default.
• W4310275976 citedByCount "0" @default.
• W4310275976 crossrefType "journal-article" @default.
• W4310275976 hasAuthorship W4310275976A5015513363 @default.
• W4310275976 hasAuthorship W4310275976A5016714350 @default.
• W4310275976 hasAuthorship W4310275976A5022495891 @default.
• W4310275976 hasAuthorship W4310275976A5022607762 @default.
• W4310275976 hasAuthorship W4310275976A5029484872 @default.
• W4310275976 hasAuthorship W4310275976A5044777415 @default.
• W4310275976 hasAuthorship W4310275976A5045584394 @default.
• W4310275976 hasAuthorship W4310275976A5046225712 @default.
• W4310275976 hasAuthorship W4310275976A5053815236 @default.
• W4310275976 hasAuthorship W4310275976A5070732604 @default.
• W4310275976 hasAuthorship W4310275976A5076075970 @default.
• W4310275976 hasAuthorship W4310275976A5081322419 @default.
• W4310275976 hasAuthorship W4310275976A5086533374 @default.
• W4310275976 hasAuthorship W4310275976A5091683676 @default.
• W4310275976 hasBestOaLocation W43102759761 @default.
• W4310275976 hasConcept C112705442 @default.
• W4310275976 hasConcept C126322002 @default.
• W4310275976 hasConcept C142724271 @default.
• W4310275976 hasConcept C197934379 @default.
• W4310275976 hasConcept C204787440 @default.
• W4310275976 hasConcept C22979827 @default.
• W4310275976 hasConcept C27081682 @default.
• W4310275976 hasConcept C2776839432 @default.
• W4310275976 hasConcept C2778375690 @default.
• W4310275976 hasConcept C2778657065 @default.
• W4310275976 hasConcept C2780499067 @default.
• W4310275976 hasConcept C2908647359 @default.
• W4310275976 hasConcept C42404028 @default.
• W4310275976 hasConcept C44249647 @default.
• W4310275976 hasConcept C71924100 @default.
• W4310275976 hasConcept C76318530 @default.

• next