FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310276514> ?p ?o ?g. }

• W4310276514 endingPage "1220" @default.
• W4310276514 startingPage "1209" @default.
• W4310276514 abstract "Estrogen receptor alpha (ERα) is a frequently mutated gene in breast cancer (BC). While many studies have investigated molecular dysregulation by hotspot mutations at Y537 and D538, which exhibit an estrogen-independent constitutively active phenotype, the functional abnormalities of other mutations remain obscure. The K303R mutation in primary invasive BC has been implicated with endocrine resistance, tumor size, and lymph node positivity. However, the impact of the K303R mutation on the cell epigenome is yet unknown.We introduced the K303R ERα mutant in ERα-negative MDA-MB-453 cells to monitor ERα-dependent transactivation and to perform epigenomic analyses. ATAC-seq and ChIP-Seq analyses indicated that both wild-type (WT) and the K303R mutant associated with Forkhead box (Fox) protein family motif regions at similar rates, even without an ERα-binding sequence, but only the K303R mutant induced chromatin opening at those regions. Biochemical analyses demonstrated that the WT and the K303R mutant can be tethered on DNA by FoxA1 indirectly, but only the K303R/FoxA1/DNA complex can induce associations with the nuclear receptor cofactor 2 (NCOA2).These findings suggest that the K303R mutant induces chromatin opening at the Fox binding region through the FoxA1-dependent associations of the K303R mutant to NCOA2 and then probably disrupts the regulation of Fox-target genes, resulting in K303R-related BC events." @default.
• W4310276514 created "2022-11-30" @default.
• W4310276514 creator A5015427845 @default.
• W4310276514 creator A5022560449 @default.
• W4310276514 creator A5055568279 @default.
• W4310276514 creator A5077405674 @default.
• W4310276514 date "2022-11-27" @default.
• W4310276514 modified "2023-10-14" @default.
• W4310276514 title "Estrogen receptor α K303R mutation reorganizes its binding to forkhead box protein A1 regions and induces chromatin opening" @default.
• W4310276514 cites W1974743726 @default.
• W4310276514 cites W1986823963 @default.
• W4310276514 cites W2002262418 @default.
• W4310276514 cites W2009090651 @default.
• W4310276514 cites W2022440206 @default.
• W4310276514 cites W2046389285 @default.
• W4310276514 cites W2056569159 @default.
• W4310276514 cites W2059569390 @default.
• W4310276514 cites W2071901592 @default.
• W4310276514 cites W2073228633 @default.
• W4310276514 cites W2073503377 @default.
• W4310276514 cites W2077934247 @default.
• W4310276514 cites W2078556843 @default.
• W4310276514 cites W2083771536 @default.
• W4310276514 cites W2117089877 @default.
• W4310276514 cites W2120052914 @default.
• W4310276514 cites W2121409164 @default.
• W4310276514 cites W2136976212 @default.
• W4310276514 cites W2138258825 @default.
• W4310276514 cites W2149972103 @default.
• W4310276514 cites W2165235386 @default.
• W4310276514 cites W2169318796 @default.
• W4310276514 cites W2246556087 @default.
• W4310276514 cites W2331147307 @default.
• W4310276514 cites W2538138106 @default.
• W4310276514 cites W2538947463 @default.
• W4310276514 cites W2605402577 @default.
• W4310276514 cites W2608458533 @default.
• W4310276514 cites W2609231907 @default.
• W4310276514 cites W2618142594 @default.
• W4310276514 cites W2789938647 @default.
• W4310276514 cites W2799561351 @default.
• W4310276514 cites W2890343309 @default.
• W4310276514 cites W2891700678 @default.
• W4310276514 cites W2910412007 @default.
• W4310276514 cites W2923550862 @default.
• W4310276514 cites W2924331445 @default.
• W4310276514 cites W2938565395 @default.
• W4310276514 cites W2958196506 @default.
• W4310276514 cites W2996427414 @default.
• W4310276514 cites W3011390508 @default.
• W4310276514 cites W3131682687 @default.
• W4310276514 cites W3205421900 @default.
• W4310276514 cites W779403461 @default.
• W4310276514 doi "https://doi.org/10.1007/s11033-022-08089-3" @default.
• W4310276514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36436079" @default.
• W4310276514 hasPublicationYear "2022" @default.
• W4310276514 type Work @default.
• W4310276514 citedByCount "0" @default.
• W4310276514 crossrefType "journal-article" @default.
• W4310276514 hasAuthorship W4310276514A5015427845 @default.
• W4310276514 hasAuthorship W4310276514A5022560449 @default.
• W4310276514 hasAuthorship W4310276514A5055568279 @default.
• W4310276514 hasAuthorship W4310276514A5077405674 @default.
• W4310276514 hasBestOaLocation W43102765141 @default.
• W4310276514 hasConcept C104317684 @default.
• W4310276514 hasConcept C121608353 @default.
• W4310276514 hasConcept C1292079 @default.
• W4310276514 hasConcept C143065580 @default.
• W4310276514 hasConcept C153911025 @default.
• W4310276514 hasConcept C154456304 @default.
• W4310276514 hasConcept C172313692 @default.
• W4310276514 hasConcept C502942594 @default.
• W4310276514 hasConcept C530470458 @default.
• W4310276514 hasConcept C54355233 @default.
• W4310276514 hasConcept C83640560 @default.
• W4310276514 hasConcept C84606932 @default.
• W4310276514 hasConcept C86339819 @default.
• W4310276514 hasConcept C86803240 @default.
• W4310276514 hasConcept C95444343 @default.
• W4310276514 hasConceptScore W4310276514C104317684 @default.
• W4310276514 hasConceptScore W4310276514C121608353 @default.
• W4310276514 hasConceptScore W4310276514C1292079 @default.
• W4310276514 hasConceptScore W4310276514C143065580 @default.
• W4310276514 hasConceptScore W4310276514C153911025 @default.
• W4310276514 hasConceptScore W4310276514C154456304 @default.
• W4310276514 hasConceptScore W4310276514C172313692 @default.
• W4310276514 hasConceptScore W4310276514C502942594 @default.
• W4310276514 hasConceptScore W4310276514C530470458 @default.
• W4310276514 hasConceptScore W4310276514C54355233 @default.
• W4310276514 hasConceptScore W4310276514C83640560 @default.
• W4310276514 hasConceptScore W4310276514C84606932 @default.
• W4310276514 hasConceptScore W4310276514C86339819 @default.
• W4310276514 hasConceptScore W4310276514C86803240 @default.
• W4310276514 hasConceptScore W4310276514C95444343 @default.
• W4310276514 hasFunder F4320334764 @default.
• W4310276514 hasIssue "2" @default.
• W4310276514 hasLocation W43102765141 @default.
• W4310276514 hasLocation W43102765142 @default.

• next