Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310277293> ?p ?o ?g. }
- W4310277293 endingPage "102" @default.
- W4310277293 startingPage "92" @default.
- W4310277293 abstract "The ever-evolving and versatile VLP technology is becoming an increasingly popular area of science. This study presents surface decorated reporter-tagged VLPs of CHIKV, an enveloped RNA virus of the genus alphavirus and its applications. Western blot, IFA and live-cell imaging confirm the expression of reporter-tagged CHIK-VLPs from transfected HEK293Ts. CryoEM micrographs reveal particle diameter as ∼67nm and 56–70 nm, respectively, for NLuc CHIK-VLPs and mCherry CHIK-VLPs. Our study demonstrates that by exploiting NLuc CHIK-VLPs as a detector probe, robust ratiometric luminescence signal in CHIKV-positive sera compared to healthy controls can be achieved swiftly. Moreover, the potential activity of the Suramin drug as a CHIKV entry inhibitor has been validated through the reporter-tagged CHIK-VLPs. The results reported in this study open new avenues in the eVLPs domain and offer potential for large-scale screening of clinical samples and antiviral agents targeting entry of CHIKV and other alphaviruses." @default.
- W4310277293 created "2022-11-30" @default.
- W4310277293 creator A5014101698 @default.
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- W4310277293 creator A5047295695 @default.
- W4310277293 creator A5055422431 @default.
- W4310277293 creator A5069864999 @default.
- W4310277293 creator A5073599539 @default.
- W4310277293 date "2023-01-01" @default.
- W4310277293 modified "2023-09-23" @default.
- W4310277293 title "Surface decorated reporter-tagged chikungunya virus-like particles for clinical diagnostics and identification of virus entry inhibitors" @default.
- W4310277293 cites W1558178924 @default.
- W4310277293 cites W1978758024 @default.
- W4310277293 cites W1984214088 @default.
- W4310277293 cites W1988336483 @default.
- W4310277293 cites W1991353963 @default.
- W4310277293 cites W1991939615 @default.
- W4310277293 cites W1994957865 @default.
- W4310277293 cites W2003040183 @default.
- W4310277293 cites W2003621334 @default.
- W4310277293 cites W2007226073 @default.
- W4310277293 cites W2016833692 @default.
- W4310277293 cites W2022342738 @default.
- W4310277293 cites W2032841462 @default.
- W4310277293 cites W2039207244 @default.
- W4310277293 cites W2048349698 @default.
- W4310277293 cites W2056036907 @default.
- W4310277293 cites W2065496099 @default.
- W4310277293 cites W2068988851 @default.
- W4310277293 cites W2070608209 @default.
- W4310277293 cites W2073517039 @default.
- W4310277293 cites W2075707505 @default.
- W4310277293 cites W2080920468 @default.
- W4310277293 cites W2080994809 @default.
- W4310277293 cites W2081537153 @default.
- W4310277293 cites W2086705873 @default.
- W4310277293 cites W2088797188 @default.
- W4310277293 cites W2089521177 @default.
- W4310277293 cites W2091590440 @default.
- W4310277293 cites W2097318849 @default.
- W4310277293 cites W2097439734 @default.
- W4310277293 cites W2103230759 @default.
- W4310277293 cites W2104217772 @default.
- W4310277293 cites W2105487210 @default.
- W4310277293 cites W2107271874 @default.
- W4310277293 cites W2115306241 @default.
- W4310277293 cites W2115734610 @default.
- W4310277293 cites W2119797892 @default.
- W4310277293 cites W2120321866 @default.
- W4310277293 cites W2139596364 @default.
- W4310277293 cites W2150436558 @default.
- W4310277293 cites W2172895128 @default.
- W4310277293 cites W2314129981 @default.
- W4310277293 cites W2325427926 @default.
- W4310277293 cites W2467786533 @default.
- W4310277293 cites W2516533647 @default.
- W4310277293 cites W2587369815 @default.
- W4310277293 cites W2588207450 @default.
- W4310277293 cites W2613515801 @default.
- W4310277293 cites W2663054479 @default.
- W4310277293 cites W2759448109 @default.
- W4310277293 cites W2765912444 @default.
- W4310277293 cites W2771983650 @default.
- W4310277293 cites W2781179471 @default.
- W4310277293 cites W2791795084 @default.
- W4310277293 cites W2795865539 @default.
- W4310277293 cites W2799489783 @default.
- W4310277293 cites W2802078612 @default.
- W4310277293 cites W2806345509 @default.
- W4310277293 cites W2807441022 @default.
- W4310277293 cites W2840225719 @default.
- W4310277293 cites W2890867439 @default.
- W4310277293 cites W2898593828 @default.
- W4310277293 cites W2911027880 @default.
- W4310277293 cites W2913579175 @default.
- W4310277293 cites W2944569912 @default.
- W4310277293 cites W2947886676 @default.
- W4310277293 cites W2969678606 @default.
- W4310277293 cites W2981366260 @default.
- W4310277293 cites W2995552435 @default.
- W4310277293 cites W2999279411 @default.
- W4310277293 cites W3006563519 @default.
- W4310277293 cites W3007741117 @default.
- W4310277293 cites W3016262209 @default.
- W4310277293 cites W3023791128 @default.
- W4310277293 cites W3041706312 @default.
- W4310277293 cites W3044234230 @default.
- W4310277293 cites W3082601821 @default.
- W4310277293 cites W3092605170 @default.
- W4310277293 cites W3095066238 @default.
- W4310277293 cites W3111489059 @default.
- W4310277293 cites W3132217836 @default.
- W4310277293 cites W3135785614 @default.
- W4310277293 cites W3158044855 @default.
- W4310277293 cites W3169220603 @default.
- W4310277293 cites W3175263337 @default.
- W4310277293 cites W3210408195 @default.
- W4310277293 cites W4213424120 @default.