Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310287757> ?p ?o ?g. }
- W4310287757 endingPage "19997" @default.
- W4310287757 startingPage "19983" @default.
- W4310287757 abstract "In the current work, we demonstrate ligand design concepts that significantly improve the superoxide dismutase (SOD) activity of a zinc complex; the catalysis is enhanced when two quinol groups are present in the polydentate ligand. We investigate the mechanism through which the quinols influence the catalysis and determine the impact of entirely removing a chelating group from the original hexadentate ligand. Our results suggest that SOD mimicry with these compounds requires a ligand that coordinates Zn(II) strongly in both its oxidized and reduced forms and that the activity proceeds through Zn(II)-semiquinone complexes. The complex with two quinols displays greatly enhanced catalytic ability, with the activity improving by as much as 450% over a related complex with a single quinol. In the reduced form of the diquinol complex, one quinol appears to coordinate to the zinc much more weakly than the other. We believe that superoxide can more readily displace this portion of the ligand, facilitating its coordination to the metal center and thereby hastening the SOD reactivity. Despite the presence of two redox-active groups that may communicate through intramolecular hydrogen bonding and redox tautomerism, only one quinol undergoes two-electron oxidation to a para-quinone during the catalysis. After the formation of the para-quinone, the remaining quinol deprotonates and binds tightly to the metal, ensuring that the complex remains intact in its oxidized state, thereby maintaining its catalytic ability. The Zn(II) complex with the diquinol ligand is highly unusual for a SOD mimic in that it performs more efficiently in phosphate solution." @default.
- W4310287757 created "2022-11-30" @default.
- W4310287757 creator A5008794951 @default.
- W4310287757 creator A5013830324 @default.
- W4310287757 creator A5021022754 @default.
- W4310287757 creator A5022945164 @default.
- W4310287757 creator A5026620315 @default.
- W4310287757 creator A5044713152 @default.
- W4310287757 creator A5044839976 @default.
- W4310287757 creator A5057904286 @default.
- W4310287757 creator A5059744107 @default.
- W4310287757 creator A5070433189 @default.
- W4310287757 creator A5089808600 @default.
- W4310287757 creator A5091406432 @default.
- W4310287757 date "2022-11-29" @default.
- W4310287757 modified "2023-10-16" @default.
- W4310287757 title "Diquinol Functionality Boosts the Superoxide Dismutase Mimicry of a Zn(II) Complex with a Redox-Active Ligand while Maintaining Catalyst Stability and Enhanced Activity in Phosphate Solution" @default.
- W4310287757 cites W1566874660 @default.
- W4310287757 cites W1817978154 @default.
- W4310287757 cites W1940436875 @default.
- W4310287757 cites W1967218213 @default.
- W4310287757 cites W1969789360 @default.
- W4310287757 cites W1974747814 @default.
- W4310287757 cites W1985339859 @default.
- W4310287757 cites W1985585379 @default.
- W4310287757 cites W1986138340 @default.
- W4310287757 cites W1986696172 @default.
- W4310287757 cites W1987096917 @default.
- W4310287757 cites W2008734180 @default.
- W4310287757 cites W2016451640 @default.
- W4310287757 cites W2027498284 @default.
- W4310287757 cites W2028661305 @default.
- W4310287757 cites W2031596649 @default.
- W4310287757 cites W2031787647 @default.
- W4310287757 cites W2040083475 @default.
- W4310287757 cites W2051802937 @default.
- W4310287757 cites W2053180614 @default.
- W4310287757 cites W2054853416 @default.
- W4310287757 cites W2059010479 @default.
- W4310287757 cites W2064637315 @default.
- W4310287757 cites W2067888080 @default.
- W4310287757 cites W2069789444 @default.
- W4310287757 cites W2072888691 @default.
- W4310287757 cites W2073057315 @default.
- W4310287757 cites W2075859995 @default.
- W4310287757 cites W2080432368 @default.
- W4310287757 cites W2081052344 @default.
- W4310287757 cites W2083602140 @default.
- W4310287757 cites W2092974256 @default.
- W4310287757 cites W2100945190 @default.
- W4310287757 cites W2100951378 @default.
- W4310287757 cites W2117770573 @default.
- W4310287757 cites W2138520198 @default.
- W4310287757 cites W2148544366 @default.
- W4310287757 cites W2156105782 @default.
- W4310287757 cites W2167590372 @default.
- W4310287757 cites W2319468872 @default.
- W4310287757 cites W2323722842 @default.
- W4310287757 cites W2418008679 @default.
- W4310287757 cites W2483111552 @default.
- W4310287757 cites W2514373129 @default.
- W4310287757 cites W2581191074 @default.
- W4310287757 cites W2588164298 @default.
- W4310287757 cites W2779821636 @default.
- W4310287757 cites W2891434307 @default.
- W4310287757 cites W2925654380 @default.
- W4310287757 cites W2996039370 @default.
- W4310287757 cites W3018489634 @default.
- W4310287757 cites W3045927404 @default.
- W4310287757 cites W3159805420 @default.
- W4310287757 cites W3178673959 @default.
- W4310287757 cites W4206899503 @default.
- W4310287757 cites W4210994877 @default.
- W4310287757 doi "https://doi.org/10.1021/acs.inorgchem.2c03256" @default.
- W4310287757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36445832" @default.
- W4310287757 hasPublicationYear "2022" @default.
- W4310287757 type Work @default.
- W4310287757 citedByCount "2" @default.
- W4310287757 countsByYear W43102877572023 @default.
- W4310287757 crossrefType "journal-article" @default.
- W4310287757 hasAuthorship W4310287757A5008794951 @default.
- W4310287757 hasAuthorship W4310287757A5013830324 @default.
- W4310287757 hasAuthorship W4310287757A5021022754 @default.
- W4310287757 hasAuthorship W4310287757A5022945164 @default.
- W4310287757 hasAuthorship W4310287757A5026620315 @default.
- W4310287757 hasAuthorship W4310287757A5044713152 @default.
- W4310287757 hasAuthorship W4310287757A5044839976 @default.
- W4310287757 hasAuthorship W4310287757A5057904286 @default.
- W4310287757 hasAuthorship W4310287757A5059744107 @default.
- W4310287757 hasAuthorship W4310287757A5070433189 @default.
- W4310287757 hasAuthorship W4310287757A5089808600 @default.
- W4310287757 hasAuthorship W4310287757A5091406432 @default.
- W4310287757 hasConcept C111233374 @default.
- W4310287757 hasConcept C116569031 @default.
- W4310287757 hasConcept C161790260 @default.
- W4310287757 hasConcept C170493617 @default.
- W4310287757 hasConcept C179104552 @default.
- W4310287757 hasConcept C185592680 @default.