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• W4310288544 abstract "Insulin, a main medication to control glycemia of type 1 and advanced type 2 diabetes, faces problems of a short half-life and poor stability during its clinical use. Zwitterionic polymer shows unique properties of antifouling and low immunogenicity. Here, we have synthesized a new insulin-zwitterionic polymer conjugate (INS-PMPC) through grafting-from strategy by controlled radical polymerization. Apart from showing excellent stability upon mechanical agitation, the resulting INS-PMPC conjugate provided over 20 h of glycemic control due to improved pharmacokinetics in diabetic mice with one single subcutaneous injection. Most importantly, this insulin-zwitterionic polymer conjugate significantly decreases the incidence of hypoglycemia." @default.
• W4310288544 created "2022-11-30" @default.
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• W4310288544 date "2023-01-23" @default.
• W4310288544 modified "2023-10-12" @default.
• W4310288544 title "Long‐Acting Insulin‐Zwitterionic Polymer Conjugate Mitigates Hypoglycemia" @default.
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• W4310288544 doi "https://doi.org/10.1002/chem.202203460" @default.
• W4310288544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36445789" @default.
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