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• W4310289319 endingPage "e202201529" @default.
• W4310289319 startingPage "e202201529" @default.
• W4310289319 abstract "Epithelial cells usually trigger their migratory machinery upon loss of adhesion to their neighbors. This default is important for both physiological (e.g., wound healing) and pathological (e.g., tumor metastasis) processes. However, the underlying mechanism for such a default remains unclear. In this study, we used the human head and neck squamous cell carcinoma (HNSCC) SAS cells as a model and found that loss of cell-cell adhesion induced reactive oxygen species (ROS) generation and vimentin expression, both of which were required for SAS cell migration upon loss of cell-cell adhesion. We demonstrated that Tiam1-mediated Rac1 activation was responsible for the ROS generation through NADPH-dependent oxidases. Moreover, the ROS-Src-STAT3 signaling pathway that led to vimentin expression was important for SAS cell migration. The activation of ROS, Src, and STAT3 was also detected in tumor biopsies from HNSCC patients. Notably, activated STAT3 was more abundant at the tumor invasive front and correlated with metastatic progression of HNSCC. Together, our results unveil a mechanism of how cells trigger their migration upon loss of cell-cell adhesion and highlight an important role of the ROS-Src-STAT3 signaling pathway in the progression of HNSCC." @default.
• W4310289319 created "2022-11-30" @default.
• W4310289319 creator A5013439988 @default.
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• W4310289319 creator A5065519288 @default.
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• W4310289319 creator A5079103321 @default.
• W4310289319 date "2022-11-29" @default.
• W4310289319 modified "2023-10-16" @default.
• W4310289319 title "Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation" @default.
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• W4310289319 doi "https://doi.org/10.26508/lsa.202201529" @default.
• W4310289319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36446524" @default.
• W4310289319 hasPublicationYear "2022" @default.
• W4310289319 type Work @default.

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