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- W4310290437 endingPage "101053" @default.
- W4310290437 startingPage "101053" @default.
- W4310290437 abstract "The increasing need for joint replacement surgeries, musculoskeletal repairs, and orthodontics worldwide prompts emerging technologies to evolve with healthcare's changing landscape. Metallic orthopaedic materials have a shared application history with the aerospace industry, making them only partly efficient in the biomedical domain. However, suitability of metallic materials in bone tissue replacements and regenerative therapies remains unchallenged due to their superior mechanical properties, eventhough they are not perfectly biocompatible. Therefore, exploring ways to improve biocompatibility is the most critical step toward designing the next generation of metallic biomaterials. This review discusses methods of improving biocompatibility of metals used in biomedical devices using surface modification, bulk modification, and incorporation of biologics. Our investigation spans multiple length scales, from bulk metals to the effect of microporosities, surface nanoarchitecture, and biomolecules such as DNA incorporation for enhanced biological response in metallic materials. We examine recent technologies such as 3D printing in alloy design and storing surface charge on nanoarchitecture surfaces, metal-on-metal, and ceramic-on-metal coatings to present a coherent and comprehensive understanding of the subject. Finally, we consider the advantages and challenges of metallic biomaterials and identify future directions." @default.
- W4310290437 created "2022-11-30" @default.
- W4310290437 creator A5000075961 @default.
- W4310290437 creator A5025156200 @default.
- W4310290437 creator A5025299067 @default.
- W4310290437 creator A5044836713 @default.
- W4310290437 creator A5060811204 @default.
- W4310290437 date "2023-03-01" @default.
- W4310290437 modified "2023-10-14" @default.
- W4310290437 title "Improving biocompatibility for next generation of metallic implants" @default.
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