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- W4310294536 abstract "B. parapertussis is a whooping cough etiological agent, whose incidence in the population has increased remarkably. Virulence factors involved in the bacterial infection, however, remain poorly investigated. We here studied the role of adenylate cyclase (CyaA), the main toxin of B. parapertussis, in the outcome of the bacterial interaction with macrophages. Our results showed that B. parapertussis CyaA intoxicates human macrophages, prevents bacterial phagocytosis and precludes phago-lysosomal fusion eventually promoting the bacterial survival to the encounter with these immune cells. Accordingly, we found that B. parapertussis CyaA induces the transcriptional downregulation of host genes encoding for antimicrobial peptides, proteins involved in bacterial intracellular killing, and the pro-inflammatory cytokine TNF-α, while induces the upregulation of the anti-inflammatory cytokine IL-10. Together with previous reports suggesting a protective role of B. parapertussis CyaA against neutrophils bactericidal activity, the results of this study suggest a central role of CyaA in B. parapertussis immune evasion and persistence." @default.
- W4310294536 created "2022-11-30" @default.
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- W4310294536 date "2023-01-01" @default.
- W4310294536 modified "2023-10-09" @default.
- W4310294536 title "Bordetella parapertussis adenylate cyclase toxin promotes the bacterial survival to the encounter with macrophages" @default.
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- W4310294536 doi "https://doi.org/10.1016/j.micpath.2022.105898" @default.
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