Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310295265> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4310295265 endingPage "S33" @default.
- W4310295265 startingPage "S31" @default.
- W4310295265 abstract "Amino acids are compounds that contain an amino group (-NH2) and a carboxyl group (-COOH) and are components of proteins and materials for various bioactive molecules. The skeletal muscle, which is the largest organ in the human body, representing ~40% of the total body weight, plays important roles in exercise, energy expenditure, and glucose/amino acid usage-processes that are modulated by various amino acids and their metabolites. In this review, we address the metabolism and function of amino acids, especially non-proteinogenic amino acids, in the skeletal muscle. Leucine, a BCAA, and its metabolite, β-hydroxy-β-methylbutyrate (HMB), both activate mammalian target of rapamycin complex 1 (mTORC1) and increase protein synthesis, but the mechanisms of activation appear to be different. The metabolite of valine (another BCAA), β-aminoisobutyric acid (BAIBA), is increased by exercise, is secreted by the skeletal muscle, and acts on other tissues, such as white adipose tissue, to increase energy expenditure. In addition, several amino acid-related molecules reportedly activate skeletal muscle function. Oral 5-aminolevulinic acid (ALA) supplementation can protect against mild hyperglycemia and help prevent type 2 diabetes. β-alanine levels are decreased in the skeletal muscles of aged mice. β-alanine supplementation increased the physical performance and improved the executive function induced by endurance exercise in middle-aged individuals. Further studies focusing on the effects of amino acids and their metabolites on skeletal muscle function will provide data essential for the production of food supplements for older adults, athletes, and individuals with metabolic diseases." @default.
- W4310295265 created "2022-11-30" @default.
- W4310295265 creator A5002714108 @default.
- W4310295265 creator A5080220170 @default.
- W4310295265 date "2022-11-30" @default.
- W4310295265 modified "2023-10-14" @default.
- W4310295265 title "Regulation of Skeletal Muscle Function by Amino Acids, Especially Non-Proteinogenic Amino Acids" @default.
- W4310295265 cites W1541998396 @default.
- W4310295265 cites W1838954128 @default.
- W4310295265 cites W1963632309 @default.
- W4310295265 cites W1970530923 @default.
- W4310295265 cites W1972344619 @default.
- W4310295265 cites W1974559463 @default.
- W4310295265 cites W1981574178 @default.
- W4310295265 cites W1986031970 @default.
- W4310295265 cites W2002364623 @default.
- W4310295265 cites W2024005016 @default.
- W4310295265 cites W2030146812 @default.
- W4310295265 cites W2164713351 @default.
- W4310295265 cites W2547841979 @default.
- W4310295265 cites W2739510344 @default.
- W4310295265 cites W2785863351 @default.
- W4310295265 cites W2793403512 @default.
- W4310295265 cites W2889500138 @default.
- W4310295265 cites W2898278143 @default.
- W4310295265 cites W2921616201 @default.
- W4310295265 cites W2955012157 @default.
- W4310295265 cites W2969705160 @default.
- W4310295265 cites W2982491244 @default.
- W4310295265 cites W3030794160 @default.
- W4310295265 doi "https://doi.org/10.3177/jnsv.68.s31" @default.
- W4310295265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36437009" @default.
- W4310295265 hasPublicationYear "2022" @default.
- W4310295265 type Work @default.
- W4310295265 citedByCount "0" @default.
- W4310295265 crossrefType "journal-article" @default.
- W4310295265 hasAuthorship W4310295265A5002714108 @default.
- W4310295265 hasAuthorship W4310295265A5080220170 @default.
- W4310295265 hasBestOaLocation W43102952651 @default.
- W4310295265 hasConcept C126322002 @default.
- W4310295265 hasConcept C134018914 @default.
- W4310295265 hasConcept C171089720 @default.
- W4310295265 hasConcept C185592680 @default.
- W4310295265 hasConcept C2776580952 @default.
- W4310295265 hasConcept C2777477808 @default.
- W4310295265 hasConcept C2777573094 @default.
- W4310295265 hasConcept C2779856020 @default.
- W4310295265 hasConcept C2779959927 @default.
- W4310295265 hasConcept C515207424 @default.
- W4310295265 hasConcept C55493867 @default.
- W4310295265 hasConcept C62231903 @default.
- W4310295265 hasConcept C62478195 @default.
- W4310295265 hasConcept C71924100 @default.
- W4310295265 hasConcept C86554907 @default.
- W4310295265 hasConcept C86803240 @default.
- W4310295265 hasConcept C98490376 @default.
- W4310295265 hasConceptScore W4310295265C126322002 @default.
- W4310295265 hasConceptScore W4310295265C134018914 @default.
- W4310295265 hasConceptScore W4310295265C171089720 @default.
- W4310295265 hasConceptScore W4310295265C185592680 @default.
- W4310295265 hasConceptScore W4310295265C2776580952 @default.
- W4310295265 hasConceptScore W4310295265C2777477808 @default.
- W4310295265 hasConceptScore W4310295265C2777573094 @default.
- W4310295265 hasConceptScore W4310295265C2779856020 @default.
- W4310295265 hasConceptScore W4310295265C2779959927 @default.
- W4310295265 hasConceptScore W4310295265C515207424 @default.
- W4310295265 hasConceptScore W4310295265C55493867 @default.
- W4310295265 hasConceptScore W4310295265C62231903 @default.
- W4310295265 hasConceptScore W4310295265C62478195 @default.
- W4310295265 hasConceptScore W4310295265C71924100 @default.
- W4310295265 hasConceptScore W4310295265C86554907 @default.
- W4310295265 hasConceptScore W4310295265C86803240 @default.
- W4310295265 hasConceptScore W4310295265C98490376 @default.
- W4310295265 hasIssue "Supplement" @default.
- W4310295265 hasLocation W43102952651 @default.
- W4310295265 hasLocation W43102952652 @default.
- W4310295265 hasOpenAccess W4310295265 @default.
- W4310295265 hasPrimaryLocation W43102952651 @default.
- W4310295265 hasRelatedWork W1899415214 @default.
- W4310295265 hasRelatedWork W1998523922 @default.
- W4310295265 hasRelatedWork W2001387036 @default.
- W4310295265 hasRelatedWork W2014288004 @default.
- W4310295265 hasRelatedWork W2026586334 @default.
- W4310295265 hasRelatedWork W2047783119 @default.
- W4310295265 hasRelatedWork W2067456796 @default.
- W4310295265 hasRelatedWork W2080181011 @default.
- W4310295265 hasRelatedWork W4310295265 @default.
- W4310295265 hasRelatedWork W607604077 @default.
- W4310295265 hasVolume "68" @default.
- W4310295265 isParatext "false" @default.
- W4310295265 isRetracted "false" @default.
- W4310295265 workType "article" @default.