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- W4310295311 endingPage "5793" @default.
- W4310295311 startingPage "5793" @default.
- W4310295311 abstract "Pancreatic ductal adenocarcinoma is one of the most threatening solid malignancies. Molecular and cellular mediators that activate paracrine signalling also regulate the dynamic interaction between pancreatic cancer cells and nerves. This reciprocal interface leads to perineural invasion (PNI), defined as the ability of cancer cells to invade nerves, similar to vascular and lymphatic metastatic cascade. Targeting PNI in pancreatic cancer might help ameliorate prognosis and pain relief. In this review, the modern knowledge of PNI in pancreatic cancer has been analysed and critically presented. We focused on molecular pathways promoting cancer progression, with particular emphasis on neuropathic pain generation, and we reviewed the current knowledge of pharmacological inhibitors of the PNI axis. PNI represents a common hallmark of PDAC and correlates with recurrence, poor prognosis and pain in pancreatic cancer patients. The interaction among pancreatic cancer cells, immune cells and nerves is biologically relevant in each stage of the disease and stimulates great interest, but the real impact of the administration of novel agents in clinical practice is limited. It is still early days for PNI-targeted treatments, and further advanced studies are needed to understand whether they could be effective tools in the clinical setting." @default.
- W4310295311 created "2022-11-30" @default.
- W4310295311 creator A5004690018 @default.
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- W4310295311 creator A5089714768 @default.
- W4310295311 date "2022-11-24" @default.
- W4310295311 modified "2023-10-15" @default.
- W4310295311 title "Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance" @default.
- W4310295311 cites W1534453667 @default.
- W4310295311 cites W1601681275 @default.
- W4310295311 cites W1816746890 @default.
- W4310295311 cites W1828220805 @default.
- W4310295311 cites W1866826175 @default.
- W4310295311 cites W1969738372 @default.
- W4310295311 cites W1971935688 @default.
- W4310295311 cites W1993631712 @default.
- W4310295311 cites W1996629211 @default.
- W4310295311 cites W2000590884 @default.
- W4310295311 cites W2019169633 @default.
- W4310295311 cites W2019559069 @default.
- W4310295311 cites W2026859755 @default.
- W4310295311 cites W2052367970 @default.
- W4310295311 cites W2057041147 @default.
- W4310295311 cites W2076766378 @default.
- W4310295311 cites W2077259998 @default.
- W4310295311 cites W2081820972 @default.
- W4310295311 cites W2107236131 @default.
- W4310295311 cites W2110847485 @default.
- W4310295311 cites W2111050079 @default.
- W4310295311 cites W2117199255 @default.
- W4310295311 cites W2120992604 @default.
- W4310295311 cites W2122338810 @default.
- W4310295311 cites W2123837094 @default.
- W4310295311 cites W2136601868 @default.
- W4310295311 cites W2155018452 @default.
- W4310295311 cites W2157212892 @default.
- W4310295311 cites W2164144654 @default.
- W4310295311 cites W2164286021 @default.
- W4310295311 cites W2261744332 @default.
- W4310295311 cites W2290839365 @default.
- W4310295311 cites W2291931403 @default.
- W4310295311 cites W2330456241 @default.
- W4310295311 cites W2495817015 @default.
- W4310295311 cites W2556922483 @default.
- W4310295311 cites W2583965456 @default.
- W4310295311 cites W2586119928 @default.
- W4310295311 cites W2589565717 @default.
- W4310295311 cites W2608868997 @default.
- W4310295311 cites W2610389649 @default.
- W4310295311 cites W2683486796 @default.
- W4310295311 cites W2768095276 @default.
- W4310295311 cites W2768241957 @default.
- W4310295311 cites W2777653092 @default.
- W4310295311 cites W2786202610 @default.
- W4310295311 cites W2791039358 @default.
- W4310295311 cites W2884803754 @default.
- W4310295311 cites W2889212234 @default.
- W4310295311 cites W2896045928 @default.
- W4310295311 cites W2896099612 @default.
- W4310295311 cites W2902800148 @default.
- W4310295311 cites W2904348480 @default.
- W4310295311 cites W2908140079 @default.
- W4310295311 cites W2922947181 @default.
- W4310295311 cites W2942993369 @default.
- W4310295311 cites W2944163816 @default.
- W4310295311 cites W2947258240 @default.
- W4310295311 cites W2949424113 @default.
- W4310295311 cites W2954483101 @default.
- W4310295311 cites W2976596173 @default.
- W4310295311 cites W2985660081 @default.
- W4310295311 cites W2989544844 @default.
- W4310295311 cites W2993979815 @default.
- W4310295311 cites W3005855303 @default.
- W4310295311 cites W3014409013 @default.
- W4310295311 cites W3019588145 @default.
- W4310295311 cites W3019668135 @default.
- W4310295311 cites W3022951533 @default.
- W4310295311 cites W3023998523 @default.
- W4310295311 cites W3037915143 @default.
- W4310295311 cites W3041843912 @default.
- W4310295311 cites W3042127674 @default.
- W4310295311 cites W3048781347 @default.
- W4310295311 cites W3080776593 @default.
- W4310295311 cites W3088703670 @default.
- W4310295311 cites W3094058164 @default.
- W4310295311 cites W3096366814 @default.
- W4310295311 cites W3108528404 @default.
- W4310295311 cites W3111670840 @default.
- W4310295311 cites W3112735128 @default.
- W4310295311 cites W3118512926 @default.
- W4310295311 cites W3119816362 @default.
- W4310295311 cites W3136039090 @default.