Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310299481> ?p ?o ?g. }
- W4310299481 abstract "Angiogenesis has been implicated in tissue injury in several noninfectious diseases, but its role in Chagas disease (CD) physiopathology is unclear.The present study aimed to investigate the effect of Trypanosoma cruzi infection on cardiac angiogenesis during the acute phase of experimental CD.The signalling pathway involved in blood vessel formation and cardiac remodelling was evaluated in Swiss Webster mice infected with the Y strain of T. cruzi. The levels of molecules involved in the regulation of angiogenesis, such as vascular endothelial growth factor-A (VEGF-A), Flk-1, phosphorylated extracellular-signal-regulated protein kinase (pERK), hypoxia-inducible factor-1α (HIF-1α), CD31, α-smooth muscle actin (α-SMA) and also the blood vessel growth were analysed during T. cruzi infection. Hearts were analysed using conventional histopathology, immunohistochemistry and western blotting.In this study, our data demonstrate that T. cruzi acute infection in mice induces exacerbated angiogenesis in the heart and parallels cardiac remodelling. In comparison with noninfected controls, the cardiac tissue of T. cruzi-infected mice presented higher levels of (i) HIF-1α, VEGF-A, Flk-1 and pERK; (ii) angiogenesis; (iii) α-SMA+ cells in the tissue; and (iv) collagen -1 deposition around blood vessels and infiltrating throughout the myocardium.We observed cardiac angiogenesis during acute experimental T. cruzi infection parallels cardiac inflammation and remodelling." @default.
- W4310299481 created "2022-11-30" @default.
- W4310299481 creator A5001272910 @default.
- W4310299481 creator A5015295735 @default.
- W4310299481 creator A5024419659 @default.
- W4310299481 creator A5026985878 @default.
- W4310299481 creator A5041345321 @default.
- W4310299481 creator A5051352877 @default.
- W4310299481 creator A5053981215 @default.
- W4310299481 creator A5061734746 @default.
- W4310299481 creator A5063623010 @default.
- W4310299481 creator A5068505786 @default.
- W4310299481 creator A5069909281 @default.
- W4310299481 creator A5091469461 @default.
- W4310299481 date "2022-01-01" @default.
- W4310299481 modified "2023-10-18" @default.
- W4310299481 title "Increased angiogenesis parallels cardiac tissue remodelling in experimental acute Trypanosoma cruzi infection" @default.
- W4310299481 cites W144164165 @default.
- W4310299481 cites W166392120 @default.
- W4310299481 cites W1675915187 @default.
- W4310299481 cites W1972209585 @default.
- W4310299481 cites W1992112921 @default.
- W4310299481 cites W2008771858 @default.
- W4310299481 cites W2009376183 @default.
- W4310299481 cites W2009812837 @default.
- W4310299481 cites W2010592415 @default.
- W4310299481 cites W2020942857 @default.
- W4310299481 cites W2023848963 @default.
- W4310299481 cites W2026252047 @default.
- W4310299481 cites W2026482022 @default.
- W4310299481 cites W2030867626 @default.
- W4310299481 cites W2036722400 @default.
- W4310299481 cites W2037192832 @default.
- W4310299481 cites W2041338170 @default.
- W4310299481 cites W2041609936 @default.
- W4310299481 cites W2044135591 @default.
- W4310299481 cites W2047470479 @default.
- W4310299481 cites W2051283137 @default.
- W4310299481 cites W2053951297 @default.
- W4310299481 cites W2061687700 @default.
- W4310299481 cites W2072839085 @default.
- W4310299481 cites W2076457024 @default.
- W4310299481 cites W2083062544 @default.
- W4310299481 cites W2083377958 @default.
- W4310299481 cites W2084284769 @default.
- W4310299481 cites W2094380534 @default.
- W4310299481 cites W2102928259 @default.
- W4310299481 cites W2113013015 @default.
- W4310299481 cites W2135039623 @default.
- W4310299481 cites W2135624268 @default.
- W4310299481 cites W2147176626 @default.
- W4310299481 cites W2148520001 @default.
- W4310299481 cites W2152381741 @default.
- W4310299481 cites W2161315258 @default.
- W4310299481 cites W2169835977 @default.
- W4310299481 cites W2171354819 @default.
- W4310299481 cites W2223739663 @default.
- W4310299481 cites W2254057616 @default.
- W4310299481 cites W2259208957 @default.
- W4310299481 cites W2964977132 @default.
- W4310299481 cites W3028823196 @default.
- W4310299481 cites W3036989676 @default.
- W4310299481 cites W3045387296 @default.
- W4310299481 cites W3093380946 @default.
- W4310299481 cites W3096578009 @default.
- W4310299481 cites W3173936255 @default.
- W4310299481 cites W3203803079 @default.
- W4310299481 cites W4224248836 @default.
- W4310299481 cites W4242512810 @default.
- W4310299481 doi "https://doi.org/10.1590/0074-02760220005" @default.
- W4310299481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36417626" @default.
- W4310299481 hasPublicationYear "2022" @default.
- W4310299481 type Work @default.
- W4310299481 citedByCount "1" @default.
- W4310299481 countsByYear W43102994812023 @default.
- W4310299481 crossrefType "journal-article" @default.
- W4310299481 hasAuthorship W4310299481A5001272910 @default.
- W4310299481 hasAuthorship W4310299481A5015295735 @default.
- W4310299481 hasAuthorship W4310299481A5024419659 @default.
- W4310299481 hasAuthorship W4310299481A5026985878 @default.
- W4310299481 hasAuthorship W4310299481A5041345321 @default.
- W4310299481 hasAuthorship W4310299481A5051352877 @default.
- W4310299481 hasAuthorship W4310299481A5053981215 @default.
- W4310299481 hasAuthorship W4310299481A5061734746 @default.
- W4310299481 hasAuthorship W4310299481A5063623010 @default.
- W4310299481 hasAuthorship W4310299481A5068505786 @default.
- W4310299481 hasAuthorship W4310299481A5069909281 @default.
- W4310299481 hasAuthorship W4310299481A5091469461 @default.
- W4310299481 hasBestOaLocation W43102994811 @default.
- W4310299481 hasConcept C112418997 @default.
- W4310299481 hasConcept C136764020 @default.
- W4310299481 hasConcept C142724271 @default.
- W4310299481 hasConcept C167734588 @default.
- W4310299481 hasConcept C203014093 @default.
- W4310299481 hasConcept C2777025900 @default.
- W4310299481 hasConcept C2777625466 @default.
- W4310299481 hasConcept C2778939058 @default.
- W4310299481 hasConcept C2780394083 @default.
- W4310299481 hasConcept C41008148 @default.
- W4310299481 hasConcept C502942594 @default.