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• W4310331485 abstract "This work aimed to construct N6-methyladenosine (m6A) regulator-based prognostic signature and evaluate the prognostic value and the intervention on tumor immune microenvironment of this m6A risk signature.Using transcriptome and clinical data of head and neck squamous cell carcinoma (HNSCC) from The Cancer Genome Atlas (TCGA), we profiled m6A regulators and constructed an m6A risk signature. The relationship between m6A modulation and immune function was studied by differential gene expression, cell type enrichment, and correlation analyses.Fifteen m6A regulators had aberrant expression in HNSCC. A three-gene m6A prognostic signature (i.e., YTHDC2, IGF2BP2, and HNRNPC) was constructed and identified as an independent prognostic indicator for HNSCC. The m6A regulator signature-based high-risk group revealed pro-tumoral immune microenvironment due to the dysregulation of immune-related gene expression, abnormal enrichment of multiple immunocytes, and production of immunoregulatory factors.This comprehensive analysis of m6A regulators and tumor immune landscape in HNSCC revealed that the m6A signature of YTHDC2, IGF2BP2, and HNRNPC could serve as a promising biomarker for monitoring HNSCC development and may be a potential target for tumor therapy in the future.目的: 利用生物信息学技术构建头颈部鳞状细胞癌（HNSCC）N6-甲基腺苷（m6A）调节因子模型，进行预后及肿瘤免疫微环境评估。方法: 利用R语言对癌症基因组图谱（TCGA）数据库HNSCC患者进行m6A调节因子风险预后模型构建，然后对不同风险组进行差异基因分析、细胞类型富集分析和临床相关性分析。结果: HNSCC中15个m6A调节因子表达异常，根据异常表达基因构建了HNSCC YTHDC2、IGF2BP2和HNRNPC三基因独立预后风险模型，其中高风险组免疫抑制相关因子及免疫细胞显著增多，抗肿瘤免疫相关因子及免疫细胞减少，呈现促肿瘤的免疫微环境。结论: 联合YTHDC2、IGF2BP2和HNRNPC的m6A调节因子风险预后模型可以有效评估HNSCC患者预后及肿瘤免疫浸润状态。." @default.
• W4310331485 created "2022-12-08" @default.
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• W4310331485 date "2022-12-01" @default.
• W4310331485 modified "2023-10-01" @default.
• W4310331485 title "Construction and clinical evaluation of N6-methyladenosine risk signature of YTHDC2, IGF2BP2, and HNRNPC in head and neck squamous cell carcinoma." @default.
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• W4310331485 doi "https://doi.org/10.7518/hxkq.2022.06.012" @default.
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