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- W4310331876 abstract "Catalytic asymmetric dearomatization (CADA) reactions is an important synthetic method for constructing enantioenriched complex cyclic systems from simple aromatic feedstocks. However, the CADA reactions of nonactivated arenes, such as naphthalenes and benzenes, have been far less explored than those of electronically activated arenes, such as phenols, naphthols and indoles. Herein, we disclose an asymmetric dearomative cyclopropanation of naphthalenes for the rapid construction of polycyclic compounds. With chiral dirhodium carboxylate as a catalyst, the dearomative cyclopropanation proceeded smoothly under mild conditions and afforded benzonorcaradiene-containing tetracycles in good yield and high enantioselectivity (up to 99% ee). Three stereogenic centers, including two all-carbon quaternary centers, were created in the dearomatization reaction. Moreover, a variety of functional groups are well-tolerated in the reaction. The products could be readily converted into other complex polycycles while maintaining the high ee value." @default.
- W4310331876 created "2022-12-08" @default.
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- W4310331876 date "2022-01-01" @default.
- W4310331876 modified "2023-10-14" @default.
- W4310331876 title "Asymmetric dearomative cyclopropanation of naphthalenes to construct polycyclic compounds" @default.
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- W4310331876 doi "https://doi.org/10.1039/d2sc04509e" @default.
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