FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310333656> ?p ?o ?g. }

• W4310333656 endingPage "453" @default.
• W4310333656 startingPage "440" @default.
• W4310333656 abstract "Background: Type I inositol polyphosphate-5-phosphatase A (INPP5A) is involved in different cellular events, including cell proliferation. Since INPP5A, HLAG1, IL-10, and matrix metalloproteinases (MMP)-21 genes play fundamental roles in esophageal squamous cell carcinoma (ESCC) tumorigenesis, we aimed in this study to clarify the possible interplay of these genes and explore the potential of these chemistries as a predictor marker for diagnosis in ESCC disease.Methods: Gene expression analysis of INPP5A, HLAG-1, IL-10, and MMP-21 was performed using relative comparative real-time PCR in 56 ESCCs compared to their margin normal tissues. Immunohistochemical staining was accomplished for INPP5A in ESCCs. Analysis of ROC curves and the AUC were applied to evaluate the diagnostic capability of the candidate genes.Results: High levels of HLA-G1, MMP-21, and IL-10 were detected in nearly 23.2%, 62.5%, and 53.5% of ESCCs compared to the normal tissues, respectively, whereas INPP5A underexpression was detected in 19.6% of ESCCs, which all tested genes indicated significant correlations with each other. The protein expression level of INPP5A in ESCC tissues was significantly lower than that of the non-tumor esophageal tissues (p = 0.001). Interestingly, the concomitant expression of the INPP5A/HLA-G1, INPP5A/MMP-21, INPP5A/IL-10, HLA-G1/MMP-21, HLA-G1/IL-10, and MMP-21/IL-10 was significantly correlated with several clinicopathological variables. INPP5A, HLA-G1, MMP-21, and IL-10 showed to be the most appropriate candidates to discriminate tumor/non-tumor groups due to the total AUCs of all combinations (>60%).Conclusion: Our results represent a new regulatory axis containing INPP5A/HLAG-1/IL-10/MMP-21 markers in ESCC development and may provide novel insight into the mechanism of immune evasion mediated by the INPP5A/HLAG-1/IL-10/MMP-21 regulatory network in the disease." @default.
• W4310333656 created "2022-12-08" @default.
• W4310333656 creator A5009179571 @default.
• W4310333656 creator A5031193069 @default.
• W4310333656 creator A5051364106 @default.
• W4310333656 creator A5082428766 @default.
• W4310333656 date "2022-10-01" @default.
• W4310333656 modified "2023-10-14" @default.
• W4310333656 title "INPP5A/HLA-G1/IL-10/MMP-21 Axis in Progression of Esophageal Squamous Cell Carcinoma" @default.
• W4310333656 cites W1568187088 @default.
• W4310333656 cites W1634699770 @default.
• W4310333656 cites W1943317391 @default.
• W4310333656 cites W1977150209 @default.
• W4310333656 cites W1981219895 @default.
• W4310333656 cites W1982946090 @default.
• W4310333656 cites W2010989950 @default.
• W4310333656 cites W2016739351 @default.
• W4310333656 cites W2022784598 @default.
• W4310333656 cites W2024019514 @default.
• W4310333656 cites W2036760453 @default.
• W4310333656 cites W2049656655 @default.
• W4310333656 cites W2054973241 @default.
• W4310333656 cites W2061782632 @default.
• W4310333656 cites W2093644567 @default.
• W4310333656 cites W2102151740 @default.
• W4310333656 cites W2112825838 @default.
• W4310333656 cites W2113467269 @default.
• W4310333656 cites W2115114792 @default.
• W4310333656 cites W2121870777 @default.
• W4310333656 cites W2133223718 @default.
• W4310333656 cites W2140036290 @default.
• W4310333656 cites W2148785961 @default.
• W4310333656 cites W2156000546 @default.
• W4310333656 cites W2230150749 @default.
• W4310333656 cites W2235137619 @default.
• W4310333656 cites W2483776236 @default.
• W4310333656 cites W2551025035 @default.
• W4310333656 cites W2584005940 @default.
• W4310333656 cites W2591615328 @default.
• W4310333656 cites W2735604939 @default.
• W4310333656 cites W2737110964 @default.
• W4310333656 cites W2763367287 @default.
• W4310333656 cites W2783656595 @default.
• W4310333656 cites W2794935303 @default.
• W4310333656 cites W2807916402 @default.
• W4310333656 cites W2883609728 @default.
• W4310333656 cites W2915736024 @default.
• W4310333656 cites W2938341288 @default.
• W4310333656 cites W2941111170 @default.
• W4310333656 cites W2946961666 @default.
• W4310333656 cites W2985610929 @default.
• W4310333656 cites W2991163352 @default.
• W4310333656 cites W3012253666 @default.
• W4310333656 cites W3114829856 @default.
• W4310333656 cites W3117437033 @default.
• W4310333656 cites W3159051203 @default.
• W4310333656 cites W3171933865 @default.
• W4310333656 cites W3177209070 @default.
• W4310333656 cites W4205134630 @default.
• W4310333656 cites W4210588363 @default.
• W4310333656 cites W4220757751 @default.
• W4310333656 cites W4220889808 @default.
• W4310333656 cites W4225713760 @default.
• W4310333656 cites W4249522930 @default.
• W4310333656 doi "https://doi.org/10.52547/ibj.3716" @default.
• W4310333656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36437782" @default.
• W4310333656 hasPublicationYear "2022" @default.
• W4310333656 type Work @default.
• W4310333656 citedByCount "1" @default.
• W4310333656 countsByYear W43103336562023 @default.
• W4310333656 crossrefType "journal-article" @default.
• W4310333656 hasAuthorship W4310333656A5009179571 @default.
• W4310333656 hasAuthorship W4310333656A5031193069 @default.
• W4310333656 hasAuthorship W4310333656A5051364106 @default.
• W4310333656 hasAuthorship W4310333656A5082428766 @default.
• W4310333656 hasBestOaLocation W43103336561 @default.
• W4310333656 hasConcept C109523444 @default.
• W4310333656 hasConcept C121608353 @default.
• W4310333656 hasConcept C126322002 @default.
• W4310333656 hasConcept C142724271 @default.
• W4310333656 hasConcept C147483822 @default.
• W4310333656 hasConcept C188280979 @default.
• W4310333656 hasConcept C203014093 @default.
• W4310333656 hasConcept C204232928 @default.
• W4310333656 hasConcept C2777546739 @default.
• W4310333656 hasConcept C2994415158 @default.
• W4310333656 hasConcept C502942594 @default.
• W4310333656 hasConcept C555283112 @default.
• W4310333656 hasConcept C71924100 @default.
• W4310333656 hasConcept C86803240 @default.
• W4310333656 hasConceptScore W4310333656C109523444 @default.
• W4310333656 hasConceptScore W4310333656C121608353 @default.
• W4310333656 hasConceptScore W4310333656C126322002 @default.
• W4310333656 hasConceptScore W4310333656C142724271 @default.
• W4310333656 hasConceptScore W4310333656C147483822 @default.
• W4310333656 hasConceptScore W4310333656C188280979 @default.
• W4310333656 hasConceptScore W4310333656C203014093 @default.
• W4310333656 hasConceptScore W4310333656C204232928 @default.

• next