Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310335651> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4310335651 endingPage "730" @default.
- W4310335651 startingPage "730" @default.
- W4310335651 abstract "Despite the wide spectrum of pediatric rhinitis, endotyping of rhinitis based on type 2 inflammation and bronchial hyper-responsiveness (BHR) is lacking. This study aimed to investigate endotypes of pediatric rhinitis using cluster analysis.Cluster analysis was performed on data from 241 children with rhinitis by using 12 variables reflecting clinical characteristics of skin prick, laboratory, and pulmonary function tests. After extracting clusters, between-cluster differences in clinical features, such as nasal symptom scores and asthma comorbidity, were assessed to investigate the association between the endotypes and clinical features.Four clusters were extracted by hierarchical cluster analysis. Cluster 1 (n = 32 [13.3%]) was the non-allergic rhinitis dominant cluster with low type 2 inflammation and the lowest rate of BHR. Patients in cluster 1 had the mildest nasal symptoms and no asthma comorbidity. Cluster 2 (n = 114 [47.3%]) was the largest cluster and exhibited intermediate type 2 inflammation and low BHR. Cluster 3 (n = 65 [27.0%]) showed high type 2 inflammation and intermediate BHR. However, the severity of nasal symptoms and asthma comorbidity in this cluster were comparable with those in cluster 2. Cluster 4 (n = 30 [12.4%]) revealed high type 2 inflammation and BHR with potential functional airway impairment. Additionally, cluster 4 displayed the most severe nasal symptoms and frequent asthma comorbidity.Four distinct endotypes of pediatric rhinitis based on allergen sensitization, type 2 inflammation, and BHR correlate to symptoms and asthma comorbidity. These endotypes may aid clinicians in understanding the wide spectrum of pediatric rhinitis." @default.
- W4310335651 created "2022-12-08" @default.
- W4310335651 creator A5010534416 @default.
- W4310335651 creator A5014390131 @default.
- W4310335651 creator A5055383636 @default.
- W4310335651 creator A5064010353 @default.
- W4310335651 creator A5078124168 @default.
- W4310335651 creator A5080473137 @default.
- W4310335651 creator A5087453924 @default.
- W4310335651 creator A5091726021 @default.
- W4310335651 date "2022-01-01" @default.
- W4310335651 modified "2023-09-30" @default.
- W4310335651 title "Distinct Endotypes of Pediatric Rhinitis Based on Cluster Analysis" @default.
- W4310335651 cites W1559503649 @default.
- W4310335651 cites W1867968160 @default.
- W4310335651 cites W1988536099 @default.
- W4310335651 cites W1994145602 @default.
- W4310335651 cites W1997205735 @default.
- W4310335651 cites W2004689238 @default.
- W4310335651 cites W2006286763 @default.
- W4310335651 cites W2052444283 @default.
- W4310335651 cites W2099449365 @default.
- W4310335651 cites W2117120822 @default.
- W4310335651 cites W2125078269 @default.
- W4310335651 cites W2135630438 @default.
- W4310335651 cites W2136712715 @default.
- W4310335651 cites W2144024927 @default.
- W4310335651 cites W2158703410 @default.
- W4310335651 cites W2336431486 @default.
- W4310335651 cites W2406250479 @default.
- W4310335651 cites W2567241185 @default.
- W4310335651 cites W2625250017 @default.
- W4310335651 cites W2808321318 @default.
- W4310335651 cites W2898551094 @default.
- W4310335651 cites W2971125692 @default.
- W4310335651 cites W2998849120 @default.
- W4310335651 cites W4252786368 @default.
- W4310335651 cites W4294141750 @default.
- W4310335651 cites W96536117 @default.
- W4310335651 doi "https://doi.org/10.4168/aair.2022.14.6.730" @default.
- W4310335651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36426400" @default.
- W4310335651 hasPublicationYear "2022" @default.
- W4310335651 type Work @default.
- W4310335651 citedByCount "2" @default.
- W4310335651 countsByYear W43103356512023 @default.
- W4310335651 crossrefType "journal-article" @default.
- W4310335651 hasAuthorship W4310335651A5010534416 @default.
- W4310335651 hasAuthorship W4310335651A5014390131 @default.
- W4310335651 hasAuthorship W4310335651A5055383636 @default.
- W4310335651 hasAuthorship W4310335651A5064010353 @default.
- W4310335651 hasAuthorship W4310335651A5078124168 @default.
- W4310335651 hasAuthorship W4310335651A5080473137 @default.
- W4310335651 hasAuthorship W4310335651A5087453924 @default.
- W4310335651 hasAuthorship W4310335651A5091726021 @default.
- W4310335651 hasBestOaLocation W43103356511 @default.
- W4310335651 hasConcept C126322002 @default.
- W4310335651 hasConcept C164866538 @default.
- W4310335651 hasConcept C199360897 @default.
- W4310335651 hasConcept C2776042228 @default.
- W4310335651 hasConcept C2779159551 @default.
- W4310335651 hasConcept C41008148 @default.
- W4310335651 hasConcept C71924100 @default.
- W4310335651 hasConceptScore W4310335651C126322002 @default.
- W4310335651 hasConceptScore W4310335651C164866538 @default.
- W4310335651 hasConceptScore W4310335651C199360897 @default.
- W4310335651 hasConceptScore W4310335651C2776042228 @default.
- W4310335651 hasConceptScore W4310335651C2779159551 @default.
- W4310335651 hasConceptScore W4310335651C41008148 @default.
- W4310335651 hasConceptScore W4310335651C71924100 @default.
- W4310335651 hasFunder F4320322034 @default.
- W4310335651 hasIssue "6" @default.
- W4310335651 hasLocation W43103356511 @default.
- W4310335651 hasLocation W43103356512 @default.
- W4310335651 hasLocation W43103356513 @default.
- W4310335651 hasOpenAccess W4310335651 @default.
- W4310335651 hasPrimaryLocation W43103356511 @default.
- W4310335651 hasRelatedWork W1974308284 @default.
- W4310335651 hasRelatedWork W2016028728 @default.
- W4310335651 hasRelatedWork W2110039310 @default.
- W4310335651 hasRelatedWork W2155740747 @default.
- W4310335651 hasRelatedWork W2192575346 @default.
- W4310335651 hasRelatedWork W2317894508 @default.
- W4310335651 hasRelatedWork W2527864898 @default.
- W4310335651 hasRelatedWork W2792693300 @default.
- W4310335651 hasRelatedWork W4322724676 @default.
- W4310335651 hasRelatedWork W55304966 @default.
- W4310335651 hasVolume "14" @default.
- W4310335651 isParatext "false" @default.
- W4310335651 isRetracted "false" @default.
- W4310335651 workType "article" @default.