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• W4310336733 abstract "Endosymbiosis with Gammaproteobacteria is fundamental for the success of bathymodioline mussels in deep-sea chemosynthesis-based ecosystems. However, the recent discovery of Campylobacteria on the gill surfaces of these mussels suggests that these host-bacterial relationships may be more complex than previously thought. Using the cold-seep mussel ( Gigantidas haimaensis) as a model, we explored this host-bacterial system by assembling the host transcriptome and genomes of its epibiotic Campylobacteria and endosymbiotic Gammaproteobacteria and quantifying their gene and protein expression levels. We found that the epibiont applies a sulfur oxidizing (SOX) multienzyme complex with the acquisition of soxB from Gammaproteobacteria for energy production and switched from a reductive tricarboxylic acid (rTCA) cycle to a Calvin-Benson-Bassham (CBB) cycle for carbon assimilation. The host provides metabolic intermediates, inorganic carbon, and thiosulfate to satisfy the materials and energy requirements of the epibiont, but whether the epibiont benefits the host is unclear. The endosymbiont adopts methane oxidation and the ribulose monophosphate pathway (RuMP) for energy production, providing the major source of energy for itself and the host. The host obtains most of its nutrients, such as lysine, glutamine, valine, isoleucine, leucine, histidine, and folate, from the endosymbiont. In addition, host pattern recognition receptors, including toll-like receptors, peptidoglycan recognition proteins, and C-type lectins, may participate in bacterial infection, maintenance, and population regulation. Overall, this study provides insights into the complex host-bacterial relationships that have enabled mussels and bacteria to thrive in deep-sea chemosynthetic ecosystems.深海偏顶蛤亚科的贻贝栖息于以化能自养为基础的深海环境，并通过鳃细胞内共生γ变形菌作为其适应极端深海环境的关键策略。近期研究发现某些深海偏顶蛤的鳃细胞表面存在一类弯曲杆菌，暗示该共生系统中宿主与细菌的互作关系可能比先前的认知更为复杂。该文以海马巨偏顶蛤（ Gigantidas haimaensis）作为研究模型，应用宿主转录组、细菌基因组和与相关基因的表达水平及蛋白质丰度，对该宿主-细菌共生系统进行了深入探究。研究结果发现海马巨偏顶蛤的体表附生菌（Campylobacteria）通过SOX多酶复合体获取能量，其中一个关键酶基因soxB来源于硫氧化γ变形菌，并且固碳方式由还原性三羧酸循环（rTCA）转变为卡尔文循环（CBB）。该体表附生菌是否对宿主有益尚且未知，但宿主却可为其提供代谢所需的中间产物、无机碳，与硫代硫酸盐以支持其生长所需的物质与能量。另外，海马巨偏顶蛤的内共生菌（Gammaproteobacteria）通过甲烷氧化与戊糖磷酸途径获取能量，为宿主及其自身提供生长所需的物质能量。其中，宿主从其内共生菌获取主要的营养物质，包括赖氨酸、谷氨酰胺、缬氨酸、异亮氨酸、亮氨酸、组氨酸，及叶酸。此外，宿主的模式识别受体，如类铎受体、肽聚糖识别蛋白、和C类凝集素，可能参与了两种细胞的感染与维持，及其种群控制等过程。综上，该研究不仅为深海偏顶蛤宿主-细菌共生体系的相互作用提供了新的见解，而且阐明了海马巨偏顶蛤繁荣于化能自养深海生态系统的生存策略。." @default.
• W4310336733 created "2022-12-08" @default.
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• W4310336733 date "2023-01-01" @default.
• W4310336733 modified "2023-09-30" @default.
• W4310336733 title "Interactions among deep-sea mussels and their epibiotic and endosymbiotic chemoautotrophic bacteria: Insights from multi-omics analysis" @default.
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• W4310336733 doi "https://doi.org/10.24272/j.issn.2095-8137.2022.279" @default.
• W4310336733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36419378" @default.
• W4310336733 hasPublicationYear "2023" @default.
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