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- W4310341376 abstract "The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main epilepsy pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, and neuroinflammation.NEs were characterized by droplet size, zeta potential, pH, in vitro release, accelerated and long-term stability studies. Anti-convulsant efficacy of the optimized formula and underlying mechanisms involved were assessed and compared to that from CH suspension given orally at a 30 folds higher dose.Optimized formula displayed a droplet size of 48.09 ± 0.83 nm, PDI 0.25 ± 0.011, sustained release, and good stability. CH treatment reduced seizures scoring, corrected behavioral and histological changes induced by Li/Pilo. Moreover, CH restored neurotransmitters balance and oxidative stress markers levels. Besides, CH induced microglia polarization from M1 to M2 hindering inflammation induced by Li/Pilo. Also, CH restored energy metabolism homeostasis via regulating protein expression of AMPK/SIRT-1/PGC-1α pathway markers. CH NE formulation was found to significantly enhance drug delivery to rats' hippocampus compared to CH suspension.Our findings prove the therapeutic efficacy of CH NE at a lower dose which could be a potential brain targeting platform to combat epilepsy." @default.
- W4310341376 created "2022-12-09" @default.
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- W4310341376 date "2022-12-12" @default.
- W4310341376 modified "2023-10-15" @default.
- W4310341376 title "Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α pathway" @default.
- W4310341376 cites W1558556156 @default.
- W4310341376 cites W1808127154 @default.
- W4310341376 cites W1856414226 @default.
- W4310341376 cites W191793640 @default.
- W4310341376 cites W1971048984 @default.
- W4310341376 cites W1991775006 @default.
- W4310341376 cites W1999544961 @default.
- W4310341376 cites W2000996401 @default.
- W4310341376 cites W2025639892 @default.
- W4310341376 cites W2031616221 @default.
- W4310341376 cites W2046650127 @default.
- W4310341376 cites W2048811481 @default.
- W4310341376 cites W2052020575 @default.
- W4310341376 cites W2055933087 @default.
- W4310341376 cites W2069844349 @default.
- W4310341376 cites W2074931859 @default.
- W4310341376 cites W2091847660 @default.
- W4310341376 cites W2092164714 @default.
- W4310341376 cites W2093918270 @default.
- W4310341376 cites W2103946141 @default.
- W4310341376 cites W2110084899 @default.
- W4310341376 cites W2116851251 @default.
- W4310341376 cites W2148169002 @default.
- W4310341376 cites W2170348694 @default.
- W4310341376 cites W2178210969 @default.
- W4310341376 cites W2293607107 @default.
- W4310341376 cites W2331778217 @default.
- W4310341376 cites W2336492617 @default.
- W4310341376 cites W2346140805 @default.
- W4310341376 cites W2463101958 @default.
- W4310341376 cites W2472324203 @default.
- W4310341376 cites W2485662396 @default.
- W4310341376 cites W2490839939 @default.
- W4310341376 cites W2560494879 @default.
- W4310341376 cites W2566085093 @default.
- W4310341376 cites W2581343401 @default.
- W4310341376 cites W2596305765 @default.
- W4310341376 cites W2767464476 @default.
- W4310341376 cites W2768499679 @default.
- W4310341376 cites W2791621549 @default.
- W4310341376 cites W2800358432 @default.
- W4310341376 cites W2807705809 @default.
- W4310341376 cites W2885494745 @default.
- W4310341376 cites W2889132447 @default.
- W4310341376 cites W2905306451 @default.
- W4310341376 cites W2911414691 @default.
- W4310341376 cites W2911761011 @default.
- W4310341376 cites W2916248332 @default.
- W4310341376 cites W2921570078 @default.
- W4310341376 cites W2939817433 @default.
- W4310341376 cites W2945333307 @default.
- W4310341376 cites W2969402300 @default.
- W4310341376 cites W2990551838 @default.
- W4310341376 cites W2990684877 @default.
- W4310341376 cites W2999564629 @default.
- W4310341376 cites W3005044780 @default.
- W4310341376 cites W3008114116 @default.
- W4310341376 cites W3008601364 @default.
- W4310341376 cites W3010252125 @default.
- W4310341376 cites W3010492895 @default.
- W4310341376 cites W3011686755 @default.
- W4310341376 cites W3012243173 @default.
- W4310341376 cites W3015821244 @default.
- W4310341376 cites W3017072443 @default.
- W4310341376 cites W3023105196 @default.
- W4310341376 cites W3038217103 @default.
- W4310341376 cites W3046114958 @default.
- W4310341376 cites W3082901559 @default.
- W4310341376 cites W3085532306 @default.
- W4310341376 cites W3088505927 @default.
- W4310341376 cites W3091691629 @default.
- W4310341376 cites W3093760381 @default.
- W4310341376 cites W3095896292 @default.
- W4310341376 cites W3106037729 @default.
- W4310341376 cites W3113445874 @default.
- W4310341376 cites W3115537331 @default.
- W4310341376 cites W3137404545 @default.
- W4310341376 cites W3162113787 @default.