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- W4310353181 endingPage "e0010929" @default.
- W4310353181 startingPage "e0010929" @default.
- W4310353181 abstract "Trichinella spiralis is a foodborne parasitic nematode which is a serious risk to meat safety. Development of anti-Trichinella vaccine is needed to control Trichinella infection in food animals. In this study, two novel T. spiralis genes (calreticulin and serine protease 1.1) in combination were used to construct oral DNA vaccines, and their induced protective immunity was evaluated in a murine model.TsCRT+TsSP1.1, TsCRT and TsSP1.1 DNA were transformed into attenuated Salmonella typhimurium ΔcyaSL1344. Oral vaccination of mice with TsCRT+TsSP1.1, TsCRT and TsSP1.1 DNA vaccines elicited a gut local mucosal sIgA response and systemic Th1/Th2 mixed response. Oral vaccination with TsCRT+TsSP1.1 induced obviously higher level of serum specific antibodies, mucosal sIgA and cellular immune response than either of single TsCRT or TsSP1.1 DNA vaccination. Oral vaccination of mice with TsCRT+TsSP1.1 exhibited a 53.4% reduction of enteral adult worms and a 46.05% reduction of muscle larvae, conferred a higher immune protection than either of individual TsCRT (44.28 and 42.46%) or TsSP1.1 DNA vaccine (35.43 and 29.29%) alone. Oral vaccination with TsCRT+TsSP1.1, TsCRT and TsSP1.1 also obviously ameliorated inflammation of intestinal mucosa and skeletal muscles of vaccinated mice after challenge.TsCRT and TsSP1.1 might be regarded the novel potential targets for anti-Trichinella vaccines. Attenuated Salmonella-delivered DNA vaccine provided a prospective approach to control T. spiralis infection in food animals." @default.
- W4310353181 created "2022-12-09" @default.
- W4310353181 creator A5004139292 @default.
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- W4310353181 creator A5069669801 @default.
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- W4310353181 creator A5076491187 @default.
- W4310353181 date "2022-11-29" @default.
- W4310353181 modified "2023-10-09" @default.
- W4310353181 title "Oral vaccination of mice with attenuated Salmonella encoding Trichinella spiralis calreticulin and serine protease 1.1 confers protective immunity in BALB/c mice" @default.
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- W4310353181 doi "https://doi.org/10.1371/journal.pntd.0010929" @default.
- W4310353181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36445875" @default.
- W4310353181 hasPublicationYear "2022" @default.
- W4310353181 type Work @default.