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- W4310353931 endingPage "104000" @default.
- W4310353931 startingPage "104000" @default.
- W4310353931 abstract "Coronavirus disease-2019 (COVID-19) may severely affect respiratory function and evolve to life-threatening hypoxia. The clinical experience led to the implementation of standardized protocols assuming similarity to severe acute respiratory syndrome (SARS-CoV-2). Understanding the histopathological and functional patterns is essential to better understand the pathophysiology of COVID-19 and then develop new therapeutic strategies. Epithelial and endothelial cell damage can result from the virus attack, thus leading to immune-mediated response. Pulmonary histopathological findings show the presence of Mallory bodies, alveolar coating cells with nuclear atypia, reactive pneumocytes, reparative fibrosis, intra-alveolar hemorrhage, moderate inflammatory infiltrates, micro-abscesses, microthrombus, hyaline membrane fragments, and emphysema-like lung areas. COVID-19 patients may present different respiratory stages from silent to critical hypoxemia, are associated with the degree of pulmonary parenchymal involvement, thus yielding alteration of ventilation and perfusion relationships. This review aims to: discuss the morphological (histopathological and radiological) and functional findings of COVID-19 compared to acute interstitial pneumonia, acute respiratory distress syndrome (ARDS), and high-altitude pulmonary edema (HAPE), four entities that share common clinical traits, but have peculiar pathophysiological features with potential implications to their clinical management." @default.
- W4310353931 created "2022-12-09" @default.
- W4310353931 creator A5011101880 @default.
- W4310353931 creator A5024355500 @default.
- W4310353931 creator A5041262870 @default.
- W4310353931 creator A5052473938 @default.
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- W4310353931 creator A5072553996 @default.
- W4310353931 creator A5086750635 @default.
- W4310353931 creator A5088925956 @default.
- W4310353931 creator A5091455922 @default.
- W4310353931 date "2023-03-01" @default.
- W4310353931 modified "2023-10-14" @default.
- W4310353931 title "Morphological and functional findings in COVID-19 lung disease as compared to Pneumonia, ARDS, and High-Altitude Pulmonary Edema" @default.
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