Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310358391> ?p ?o ?g. }
- W4310358391 endingPage "e0278220" @default.
- W4310358391 startingPage "e0278220" @default.
- W4310358391 abstract "Melanoma shows highly aggressive behavior (i.e., local invasion and metastasis). Matrix metalloprotease-3 (MMP-3), a zinc-dependent endopeptidase, degrades several extracellular substrates and contributes to local invasion by creating a microenvironment suitable for tumor development. Here, we report that interleukin-1β (IL-1β) triggers the MMP-3 expression in canine melanoma cells. The activity of MMP-3 in the culture supernatant was increased in IL-1β-treated melanoma cells. IL-1β time- and dose-dependently provoked the mRNA expression of MMP-3. IL-1β induced the migration of melanoma cells; however, this migration was attenuated by UK356618, an MMP-3 inhibitor. When the cells were treated with the nuclear factor-κB (NF-κB) inhibitor TPCA-1, the inhibition of MMP-3 expression was observed. In IL-1β-treated cells, the phosphorylation both of p65/RelA and p105 was detected, indicating NF-κB pathway activation. In p65/RelA-depleted melanoma cells, IL-1β-mediated mRNA expression of MMP-3 was inhibited, whereas this reduction was not observed in p105-depleted cells. These findings suggest that MMP-3 expression in melanoma cells is regulated through IL-1β-mediated p65/RelA activation, which is involved in melanoma cell migration." @default.
- W4310358391 created "2022-12-09" @default.
- W4310358391 creator A5011601288 @default.
- W4310358391 creator A5019607925 @default.
- W4310358391 creator A5027617262 @default.
- W4310358391 creator A5037034350 @default.
- W4310358391 creator A5038306405 @default.
- W4310358391 creator A5041327512 @default.
- W4310358391 creator A5061663577 @default.
- W4310358391 creator A5069348272 @default.
- W4310358391 creator A5074609060 @default.
- W4310358391 creator A5083670456 @default.
- W4310358391 creator A5084105797 @default.
- W4310358391 creator A5085105011 @default.
- W4310358391 creator A5087211748 @default.
- W4310358391 date "2022-11-29" @default.
- W4310358391 modified "2023-10-14" @default.
- W4310358391 title "Interleukin-1β triggers matrix metalloprotease-3 expression through p65/RelA activation in melanoma cells" @default.
- W4310358391 cites W1482195692 @default.
- W4310358391 cites W1533021978 @default.
- W4310358391 cites W1772675489 @default.
- W4310358391 cites W1804633340 @default.
- W4310358391 cites W1806896498 @default.
- W4310358391 cites W1901450118 @default.
- W4310358391 cites W1918610557 @default.
- W4310358391 cites W1944061732 @default.
- W4310358391 cites W1965765543 @default.
- W4310358391 cites W1967483014 @default.
- W4310358391 cites W1972908310 @default.
- W4310358391 cites W1973135358 @default.
- W4310358391 cites W1978743225 @default.
- W4310358391 cites W1981732884 @default.
- W4310358391 cites W1987586145 @default.
- W4310358391 cites W1992912936 @default.
- W4310358391 cites W1996582404 @default.
- W4310358391 cites W1997903004 @default.
- W4310358391 cites W2003120820 @default.
- W4310358391 cites W2005521257 @default.
- W4310358391 cites W2007443131 @default.
- W4310358391 cites W2038370680 @default.
- W4310358391 cites W2038714362 @default.
- W4310358391 cites W2039770403 @default.
- W4310358391 cites W2046377705 @default.
- W4310358391 cites W2050516456 @default.
- W4310358391 cites W2051347744 @default.
- W4310358391 cites W2053896971 @default.
- W4310358391 cites W2061201598 @default.
- W4310358391 cites W2073882423 @default.
- W4310358391 cites W2076833694 @default.
- W4310358391 cites W2078480515 @default.
- W4310358391 cites W2082018267 @default.
- W4310358391 cites W2086299681 @default.
- W4310358391 cites W2097476621 @default.
- W4310358391 cites W2099257830 @default.
- W4310358391 cites W2101327682 @default.
- W4310358391 cites W2104692426 @default.
- W4310358391 cites W2114279859 @default.
- W4310358391 cites W2117756942 @default.
- W4310358391 cites W2118278569 @default.
- W4310358391 cites W2123105952 @default.
- W4310358391 cites W2128584338 @default.
- W4310358391 cites W2128635872 @default.
- W4310358391 cites W2129242841 @default.
- W4310358391 cites W2135919238 @default.
- W4310358391 cites W2138934663 @default.
- W4310358391 cites W2140432305 @default.
- W4310358391 cites W2154695292 @default.
- W4310358391 cites W2165275387 @default.
- W4310358391 cites W2166723305 @default.
- W4310358391 cites W2168151332 @default.
- W4310358391 cites W2171777194 @default.
- W4310358391 cites W2184767680 @default.
- W4310358391 cites W2271351171 @default.
- W4310358391 cites W2283160875 @default.
- W4310358391 cites W2300735552 @default.
- W4310358391 cites W2302759685 @default.
- W4310358391 cites W2409710963 @default.
- W4310358391 cites W2412208010 @default.
- W4310358391 cites W2556734269 @default.
- W4310358391 cites W2571290909 @default.
- W4310358391 cites W2585370594 @default.
- W4310358391 cites W2620769476 @default.
- W4310358391 cites W2742865544 @default.
- W4310358391 cites W2794151344 @default.
- W4310358391 cites W2805075653 @default.
- W4310358391 cites W2902538632 @default.
- W4310358391 cites W2904180088 @default.
- W4310358391 cites W2904754040 @default.
- W4310358391 cites W2953415994 @default.
- W4310358391 cites W2963088923 @default.
- W4310358391 cites W2973456055 @default.
- W4310358391 cites W2974246080 @default.
- W4310358391 cites W3013350003 @default.
- W4310358391 cites W3013894205 @default.
- W4310358391 cites W3091911794 @default.
- W4310358391 cites W3117437033 @default.
- W4310358391 cites W3126501141 @default.
- W4310358391 cites W3134823480 @default.