Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310359350> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4310359350 abstract "Abstract Nowadays, the development of medicine is inextricably linked with the use of new products, often with unique features. Nanotechnology deals with the creation of materials with specific properties in order to meet the requirements. This paper addresses issues related to the use of nanoparticles as drug delivery carriers, with a particular focus on titanium dioxide nanoparticles. To reduce the release of harmful titanium ions from the carrier surface, the materials were modified. In the first stage of research work, TiO 2 nanoparticles were prepared by sol-gel method. Their surface was coated with an organic substance, i.e. glutathione. The properties of the obtained materials were then investigated, including particle size, specific surface area and microscopic morphology. In the next stage of the study, the amount of titanium ions released from the modified carriers was determined. For this purpose, leaching of nanoparticle samples in deionized water environment was performed. Another stage included the assessment of an active substance releasing froth the prepared materials loaded with tadalafil. In vitro studies were also performed. Cytotoxic and mutagenic properties of the obtained materials in relation to CHO cells were investigated. The results obtained confirmed a decrease in the amount of titanium ions released in comparison to the reference material in which no modifier was used. In addition, the obtained materials show satisfactory purity and surface morphology allowing the formation of carrier-drug interfaces. The results of in vitro studies let us to claim that the prepared modified titanium dioxide nanoparticles have a great potential for being applied as drug carrier." @default.
- W4310359350 created "2022-12-09" @default.
- W4310359350 creator A5000298303 @default.
- W4310359350 creator A5027618688 @default.
- W4310359350 creator A5041749815 @default.
- W4310359350 creator A5071469177 @default.
- W4310359350 creator A5080337524 @default.
- W4310359350 creator A5085686334 @default.
- W4310359350 date "2022-11-29" @default.
- W4310359350 modified "2023-10-16" @default.
- W4310359350 title "In vitro studies of titanium dioxide nanoparticles modified with glutathione as a potential drug delivery system" @default.
- W4310359350 cites W2082790126 @default.
- W4310359350 cites W2808153152 @default.
- W4310359350 cites W2811478723 @default.
- W4310359350 cites W4253787748 @default.
- W4310359350 doi "https://doi.org/10.21203/rs.3.rs-2300558/v1" @default.
- W4310359350 hasPublicationYear "2022" @default.
- W4310359350 type Work @default.
- W4310359350 citedByCount "0" @default.
- W4310359350 crossrefType "posted-content" @default.
- W4310359350 hasAuthorship W4310359350A5000298303 @default.
- W4310359350 hasAuthorship W4310359350A5027618688 @default.
- W4310359350 hasAuthorship W4310359350A5041749815 @default.
- W4310359350 hasAuthorship W4310359350A5071469177 @default.
- W4310359350 hasAuthorship W4310359350A5080337524 @default.
- W4310359350 hasAuthorship W4310359350A5085686334 @default.
- W4310359350 hasBestOaLocation W43103593501 @default.
- W4310359350 hasConcept C115537861 @default.
- W4310359350 hasConcept C127413603 @default.
- W4310359350 hasConcept C155672457 @default.
- W4310359350 hasConcept C159390177 @default.
- W4310359350 hasConcept C159750122 @default.
- W4310359350 hasConcept C161790260 @default.
- W4310359350 hasConcept C163114375 @default.
- W4310359350 hasConcept C171250308 @default.
- W4310359350 hasConcept C178790620 @default.
- W4310359350 hasConcept C185592680 @default.
- W4310359350 hasConcept C187530423 @default.
- W4310359350 hasConcept C191897082 @default.
- W4310359350 hasConcept C192562407 @default.
- W4310359350 hasConcept C2777402863 @default.
- W4310359350 hasConcept C2777593239 @default.
- W4310359350 hasConcept C2779820397 @default.
- W4310359350 hasConcept C39432304 @default.
- W4310359350 hasConcept C42360764 @default.
- W4310359350 hasConcept C506065880 @default.
- W4310359350 hasConcept C65165184 @default.
- W4310359350 hasConcept C90982505 @default.
- W4310359350 hasConceptScore W4310359350C115537861 @default.
- W4310359350 hasConceptScore W4310359350C127413603 @default.
- W4310359350 hasConceptScore W4310359350C155672457 @default.
- W4310359350 hasConceptScore W4310359350C159390177 @default.
- W4310359350 hasConceptScore W4310359350C159750122 @default.
- W4310359350 hasConceptScore W4310359350C161790260 @default.
- W4310359350 hasConceptScore W4310359350C163114375 @default.
- W4310359350 hasConceptScore W4310359350C171250308 @default.
- W4310359350 hasConceptScore W4310359350C178790620 @default.
- W4310359350 hasConceptScore W4310359350C185592680 @default.
- W4310359350 hasConceptScore W4310359350C187530423 @default.
- W4310359350 hasConceptScore W4310359350C191897082 @default.
- W4310359350 hasConceptScore W4310359350C192562407 @default.
- W4310359350 hasConceptScore W4310359350C2777402863 @default.
- W4310359350 hasConceptScore W4310359350C2777593239 @default.
- W4310359350 hasConceptScore W4310359350C2779820397 @default.
- W4310359350 hasConceptScore W4310359350C39432304 @default.
- W4310359350 hasConceptScore W4310359350C42360764 @default.
- W4310359350 hasConceptScore W4310359350C506065880 @default.
- W4310359350 hasConceptScore W4310359350C65165184 @default.
- W4310359350 hasConceptScore W4310359350C90982505 @default.
- W4310359350 hasLocation W43103593501 @default.
- W4310359350 hasOpenAccess W4310359350 @default.
- W4310359350 hasPrimaryLocation W43103593501 @default.
- W4310359350 hasRelatedWork W1980323044 @default.
- W4310359350 hasRelatedWork W2118222171 @default.
- W4310359350 hasRelatedWork W2254173971 @default.
- W4310359350 hasRelatedWork W2333720888 @default.
- W4310359350 hasRelatedWork W2737426706 @default.
- W4310359350 hasRelatedWork W2760668057 @default.
- W4310359350 hasRelatedWork W2804537378 @default.
- W4310359350 hasRelatedWork W2913205149 @default.
- W4310359350 hasRelatedWork W3121348459 @default.
- W4310359350 hasRelatedWork W3205515614 @default.
- W4310359350 isParatext "false" @default.
- W4310359350 isRetracted "false" @default.
- W4310359350 workType "article" @default.