Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310361771> ?p ?o ?g. }
- W4310361771 abstract "Abstract STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis. However, if and how STING exerts innate immunity‐independent function remains elusive. Here, the authors report that STING expression is increased in renal cell carcinoma (RCC) patients and governs tumor growth through non‐canonical innate immune signaling involving mitochondrial ROS maintenance and calcium homeostasis. Mitochondrial voltage‐dependent anion channel VDAC2 is identified as a new STING binding partner. STING depletion potentiates VDAC2/GRP75‐mediated MERC (mitochondria‐ER contact) formation to increase mitochondrial ROS/calcium levels, impairs mitochondria function, and suppresses mTORC1/S6K signaling leading to RCC growth retardation. STING interaction with VDAC2 occurs through STING‐C88/C91 palmitoylation and inhibiting STING palmitoyl‐transferases ZDHHCs by 2‐BP significantly impedes RCC cell growth alone or in combination with sorafenib. Together, these studies reveal an innate immunity‐independent function of STING in regulating mitochondrial function and growth in RCC, providing a rationale to target the STING/VDAC2 interaction in treating RCC." @default.
- W4310361771 created "2022-12-09" @default.
- W4310361771 creator A5001524084 @default.
- W4310361771 creator A5001832821 @default.
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- W4310361771 creator A5023947283 @default.
- W4310361771 creator A5043825862 @default.
- W4310361771 creator A5048419710 @default.
- W4310361771 creator A5050568621 @default.
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- W4310361771 creator A5056402774 @default.
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- W4310361771 creator A5078355510 @default.
- W4310361771 creator A5079452824 @default.
- W4310361771 creator A5085186808 @default.
- W4310361771 creator A5088756989 @default.
- W4310361771 date "2022-11-29" @default.
- W4310361771 modified "2023-10-17" @default.
- W4310361771 title "STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity" @default.
- W4310361771 cites W1165140024 @default.
- W4310361771 cites W1809723326 @default.
- W4310361771 cites W1968178474 @default.
- W4310361771 cites W1975617209 @default.
- W4310361771 cites W1984785146 @default.
- W4310361771 cites W1986303112 @default.
- W4310361771 cites W1995744610 @default.
- W4310361771 cites W2006129738 @default.
- W4310361771 cites W2015310325 @default.
- W4310361771 cites W2024592805 @default.
- W4310361771 cites W2031182394 @default.
- W4310361771 cites W2055063197 @default.
- W4310361771 cites W2060004514 @default.
- W4310361771 cites W2067841051 @default.
- W4310361771 cites W2068833431 @default.
- W4310361771 cites W2072510538 @default.
- W4310361771 cites W2075514757 @default.
- W4310361771 cites W2075688750 @default.
- W4310361771 cites W2083147016 @default.
- W4310361771 cites W2083860129 @default.
- W4310361771 cites W2086050696 @default.
- W4310361771 cites W2099610218 @default.
- W4310361771 cites W2117692658 @default.
- W4310361771 cites W2126323313 @default.
- W4310361771 cites W2135014000 @default.
- W4310361771 cites W2140126848 @default.
- W4310361771 cites W2148931486 @default.
- W4310361771 cites W2158702015 @default.
- W4310361771 cites W2161549748 @default.
- W4310361771 cites W2169456326 @default.
- W4310361771 cites W2173816666 @default.
- W4310361771 cites W2179438025 @default.
- W4310361771 cites W2220279767 @default.
- W4310361771 cites W2300023009 @default.
- W4310361771 cites W2335231951 @default.
- W4310361771 cites W2466965232 @default.
- W4310361771 cites W2469317767 @default.
- W4310361771 cites W2469871926 @default.
- W4310361771 cites W2525369565 @default.
- W4310361771 cites W2548572450 @default.
- W4310361771 cites W2580868078 @default.
- W4310361771 cites W2586653152 @default.
- W4310361771 cites W2592811885 @default.
- W4310361771 cites W2595963502 @default.
- W4310361771 cites W2603207919 @default.
- W4310361771 cites W2761784274 @default.
- W4310361771 cites W2789915165 @default.
- W4310361771 cites W2792824713 @default.
- W4310361771 cites W2800226737 @default.
- W4310361771 cites W2807341565 @default.
- W4310361771 cites W2810166643 @default.
- W4310361771 cites W2854081253 @default.
- W4310361771 cites W2887637071 @default.
- W4310361771 cites W2888510964 @default.
- W4310361771 cites W2889803986 @default.
- W4310361771 cites W2901467144 @default.
- W4310361771 cites W2901573161 @default.
- W4310361771 cites W2902529436 @default.
- W4310361771 cites W2911642321 @default.
- W4310361771 cites W2919692138 @default.
- W4310361771 cites W2924757324 @default.
- W4310361771 cites W2931233285 @default.
- W4310361771 cites W2940888331 @default.
- W4310361771 cites W2950889989 @default.
- W4310361771 cites W2971339280 @default.
- W4310361771 cites W2979192059 @default.
- W4310361771 cites W2979668267 @default.
- W4310361771 cites W2982402173 @default.
- W4310361771 cites W2986456455 @default.
- W4310361771 cites W3006603528 @default.
- W4310361771 cites W3008524405 @default.
- W4310361771 cites W3038995504 @default.
- W4310361771 cites W3042830635 @default.
- W4310361771 cites W3049716412 @default.
- W4310361771 cites W3061136593 @default.
- W4310361771 cites W3083495205 @default.
- W4310361771 cites W3145334405 @default.
- W4310361771 cites W3165726173 @default.
- W4310361771 cites W3193770639 @default.
- W4310361771 cites W3217762181 @default.
- W4310361771 cites W4224209976 @default.