FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4310363331> ?p ?o ?g. }

• W4310363331 abstract "Melanin-concentrating hormone (MCH) neurons within the hypothalamus are heterogeneous and can coexpress additional neuropeptides and transmitters. The majority of MCH neurons express vesicular transporters to package glutamate for synaptic release, and MCH neurons can directly innervate downstream neurons via glutamate release. Although glutamatergic signalling from MCH neurons may support physiological and behavioural roles that are independent of MCH (e.g., in glucose homeostasis and nutrient-sensing), it can also mediate similar roles to MCH in the regulation of energy balance. In addition to energy balance, the MCH system has also been implicated in mood disorders, as MCH receptor antagonists have anxiolytic and anti-depressive effects. However, the contribution of glutamatergic signalling from MCH neurons to mood-related functions have not been investigated. We crossed Mch-cre mice with floxed-Vglut2 mice to delete the expression of the vesicular glutamate transporter 2 (Vglut2) and disable glutamatergic signalling specifically from MCH neurons. The resulting Mch-Vglut2-KO mice showed Vglut2 deletion from over 75% of MCH neurons, and although we did not observe changes in depressive-like behaviours, we found that Mch-Vglut2-KO mice displayed anxiety-like behaviours. Mch-Vglut2-KO mice showed reduced exploratory activity when placed in a new cage and were quicker to consume food placed in the centre of a novel open arena. These findings showed that Vglut2 deletion from MCH neurons resulted in anxiolytic actions and suggested that the anxiogenic effects of glutamate are similar to those of the MCH peptide. Taken together, these findings suggest that glutamate and MCH may synergize to regulate and promote anxiety-like behaviour." @default.
• W4310363331 created "2022-12-09" @default.
• W4310363331 creator A5010229707 @default.
• W4310363331 creator A5029470979 @default.
• W4310363331 creator A5054363367 @default.
• W4310363331 creator A5057393417 @default.
• W4310363331 creator A5072549724 @default.
• W4310363331 date "2022-12-18" @default.
• W4310363331 modified "2023-10-08" @default.
• W4310363331 title "Loss of glutamatergic signalling from <scp>MCH</scp> neurons reduced anxiety‐like behaviours in novel environments" @default.
• W4310363331 cites W1481893565 @default.
• W4310363331 cites W1919602086 @default.
• W4310363331 cites W1972887738 @default.
• W4310363331 cites W1978082185 @default.
• W4310363331 cites W1985681303 @default.
• W4310363331 cites W1989388706 @default.
• W4310363331 cites W1993137505 @default.
• W4310363331 cites W2007920371 @default.
• W4310363331 cites W2020793513 @default.
• W4310363331 cites W2028658132 @default.
• W4310363331 cites W2032668395 @default.
• W4310363331 cites W2034100484 @default.
• W4310363331 cites W2036636117 @default.
• W4310363331 cites W2041122912 @default.
• W4310363331 cites W2049903091 @default.
• W4310363331 cites W2050923936 @default.
• W4310363331 cites W2054376889 @default.
• W4310363331 cites W2063736752 @default.
• W4310363331 cites W2067136906 @default.
• W4310363331 cites W2069917238 @default.
• W4310363331 cites W2071358231 @default.
• W4310363331 cites W2081710585 @default.
• W4310363331 cites W2102050521 @default.
• W4310363331 cites W2110159815 @default.
• W4310363331 cites W2118574727 @default.
• W4310363331 cites W2124711253 @default.
• W4310363331 cites W2125654139 @default.
• W4310363331 cites W2166745166 @default.
• W4310363331 cites W2169608553 @default.
• W4310363331 cites W2171254754 @default.
• W4310363331 cites W2323445947 @default.
• W4310363331 cites W2401816914 @default.
• W4310363331 cites W2773050300 @default.
• W4310363331 cites W2800418364 @default.
• W4310363331 cites W2809608056 @default.
• W4310363331 cites W2895827744 @default.
• W4310363331 cites W2946753082 @default.
• W4310363331 cites W2948899114 @default.
• W4310363331 cites W2966348769 @default.
• W4310363331 cites W2970488887 @default.
• W4310363331 cites W3027412899 @default.
• W4310363331 cites W3048632350 @default.
• W4310363331 cites W3132993846 @default.
• W4310363331 cites W4290739533 @default.
• W4310363331 cites W625679400 @default.
• W4310363331 doi "https://doi.org/10.1111/jne.13222" @default.
• W4310363331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36529144" @default.
• W4310363331 hasPublicationYear "2022" @default.
• W4310363331 type Work @default.
• W4310363331 citedByCount "1" @default.
• W4310363331 countsByYear W43103633312023 @default.
• W4310363331 crossrefType "journal-article" @default.
• W4310363331 hasAuthorship W4310363331A5010229707 @default.
• W4310363331 hasAuthorship W4310363331A5029470979 @default.
• W4310363331 hasAuthorship W4310363331A5054363367 @default.
• W4310363331 hasAuthorship W4310363331A5057393417 @default.
• W4310363331 hasAuthorship W4310363331A5072549724 @default.
• W4310363331 hasConcept C118303440 @default.
• W4310363331 hasConcept C126322002 @default.
• W4310363331 hasConcept C134018914 @default.
• W4310363331 hasConcept C169760540 @default.
• W4310363331 hasConcept C170493617 @default.
• W4310363331 hasConcept C2491326 @default.
• W4310363331 hasConcept C2776632733 @default.
• W4310363331 hasConcept C2777003273 @default.
• W4310363331 hasConcept C2777765862 @default.
• W4310363331 hasConcept C2780648746 @default.
• W4310363331 hasConcept C61174792 @default.
• W4310363331 hasConcept C71924100 @default.
• W4310363331 hasConcept C86803240 @default.
• W4310363331 hasConceptScore W4310363331C118303440 @default.
• W4310363331 hasConceptScore W4310363331C126322002 @default.
• W4310363331 hasConceptScore W4310363331C134018914 @default.
• W4310363331 hasConceptScore W4310363331C169760540 @default.
• W4310363331 hasConceptScore W4310363331C170493617 @default.
• W4310363331 hasConceptScore W4310363331C2491326 @default.
• W4310363331 hasConceptScore W4310363331C2776632733 @default.
• W4310363331 hasConceptScore W4310363331C2777003273 @default.
• W4310363331 hasConceptScore W4310363331C2777765862 @default.
• W4310363331 hasConceptScore W4310363331C2780648746 @default.
• W4310363331 hasConceptScore W4310363331C61174792 @default.
• W4310363331 hasConceptScore W4310363331C71924100 @default.
• W4310363331 hasConceptScore W4310363331C86803240 @default.
• W4310363331 hasFunder F4320334506 @default.
• W4310363331 hasFunder F4320334593 @default.
• W4310363331 hasLocation W43103633311 @default.
• W4310363331 hasLocation W43103633312 @default.
• W4310363331 hasOpenAccess W4310363331 @default.
• W4310363331 hasPrimaryLocation W43103633311 @default.
• W4310363331 hasRelatedWork W1967501438 @default.

• next