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- W4310364518 abstract "The genetic association of coronavirus disease 2019 (COVID-19) with its complications has not been fully understood. This study aimed to identify variants and haplotypes of candidate genes implicated in COVID-19 related traits by combining the literature review and pathway analysis. To explore such genes, the protein-protein interactions and relevant pathways of COVID-19-associated genes were assessed. A number of variants on candidate genes were identified from Genome-wide association studies (GWASs) which were associated with COVID-19 related traits (p ˂ 10-6 ). Haplotypic blocks were assessed using haplotypic structures among the 1000 Genomes Project (r2 ≥ 0.8, D' ≥ 0.8). Further functional analyses were performed on the selected variants. The results demonstrated that a group of variants in ACE and AGT genes were significantly correlated with COVID-19 related traits. Three haplotypes were identified to be involved in the blood metabolites levels and the development of blood pressure. Functional analyses revealed that most GWAS index variants were expression quantitative trait loci and had transcription factor binding sites, exonic splicing enhancers or silencer activities. Furthermore, the proxy haplotype variants, rs4316, rs4353, rs4359, and three variants, namely rs2493133, rs2478543, and rs5051, were associated with blood metabolite and systolic blood pressure, respectively. These variants exerted more regulatory effects compared with other GWAS variants. The present study indicates that the genetic variants and candidate haplotypes of COVID-19 related genes are associated with blood pressure and blood metabolites. However, further observational studies are warranted to confirm these results." @default.
- W4310364518 created "2022-12-09" @default.
- W4310364518 creator A5022861225 @default.
- W4310364518 creator A5038587487 @default.
- W4310364518 creator A5058335133 @default.
- W4310364518 creator A5080643385 @default.
- W4310364518 creator A5090048295 @default.
- W4310364518 date "2022-12-08" @default.
- W4310364518 modified "2023-10-16" @default.
- W4310364518 title "Haplotypic variants of COVID‐19 related genes are associated with blood pressure and metabolites levels" @default.
- W4310364518 cites W1790281615 @default.
- W4310364518 cites W1804932677 @default.
- W4310364518 cites W1926182559 @default.
- W4310364518 cites W1971151747 @default.
- W4310364518 cites W1982401091 @default.
- W4310364518 cites W1984856321 @default.
- W4310364518 cites W1989568128 @default.
- W4310364518 cites W1990006899 @default.
- W4310364518 cites W1992891812 @default.
- W4310364518 cites W1997155725 @default.
- W4310364518 cites W2019727519 @default.
- W4310364518 cites W2023525998 @default.
- W4310364518 cites W2025847980 @default.
- W4310364518 cites W2025849442 @default.
- W4310364518 cites W2028156288 @default.
- W4310364518 cites W2069006981 @default.
- W4310364518 cites W2080426060 @default.
- W4310364518 cites W2092420777 @default.
- W4310364518 cites W2095479639 @default.
- W4310364518 cites W2107517347 @default.
- W4310364518 cites W2117977572 @default.
- W4310364518 cites W2120290418 @default.
- W4310364518 cites W2124223485 @default.
- W4310364518 cites W2127526635 @default.
- W4310364518 cites W2131328125 @default.
- W4310364518 cites W2134629862 @default.
- W4310364518 cites W2135730805 @default.
- W4310364518 cites W2136413073 @default.
- W4310364518 cites W2136482257 @default.
- W4310364518 cites W2141820415 @default.
- W4310364518 cites W2151578735 @default.
- W4310364518 cites W2159482845 @default.
- W4310364518 cites W2166711199 @default.
- W4310364518 cites W2176853904 @default.
- W4310364518 cites W2234335362 @default.
- W4310364518 cites W2331834241 @default.
- W4310364518 cites W2337573400 @default.
- W4310364518 cites W2346626662 @default.
- W4310364518 cites W2518986366 @default.
- W4310364518 cites W2519445944 @default.
- W4310364518 cites W2556167715 @default.
- W4310364518 cites W2566116513 @default.
- W4310364518 cites W2568784163 @default.
- W4310364518 cites W2576170476 @default.
- W4310364518 cites W2593636852 @default.
- W4310364518 cites W2609071159 @default.
- W4310364518 cites W2614844078 @default.
- W4310364518 cites W2734654187 @default.
- W4310364518 cites W2735404270 @default.
- W4310364518 cites W2737154013 @default.
- W4310364518 cites W2765794416 @default.
- W4310364518 cites W2768202056 @default.
- W4310364518 cites W2775065465 @default.
- W4310364518 cites W2775393828 @default.
- W4310364518 cites W2777667999 @default.
- W4310364518 cites W2786593082 @default.
- W4310364518 cites W2789833091 @default.
- W4310364518 cites W2792859845 @default.
- W4310364518 cites W2805712258 @default.
- W4310364518 cites W2808973857 @default.
- W4310364518 cites W2809193491 @default.
- W4310364518 cites W2883573930 @default.
- W4310364518 cites W2884987722 @default.
- W4310364518 cites W2885870007 @default.
- W4310364518 cites W2889708113 @default.
- W4310364518 cites W2891978345 @default.
- W4310364518 cites W2896510555 @default.
- W4310364518 cites W2900569176 @default.
- W4310364518 cites W2903782905 @default.
- W4310364518 cites W2905221341 @default.
- W4310364518 cites W2914232633 @default.
- W4310364518 cites W2952977999 @default.
- W4310364518 cites W2963693783 @default.
- W4310364518 cites W2968081931 @default.
- W4310364518 cites W2976616515 @default.
- W4310364518 cites W3014784601 @default.
- W4310364518 cites W3015146370 @default.
- W4310364518 cites W3021917713 @default.
- W4310364518 cites W3022494076 @default.
- W4310364518 cites W3023141957 @default.
- W4310364518 cites W3034110780 @default.
- W4310364518 cites W3038176257 @default.
- W4310364518 cites W3042860993 @default.
- W4310364518 cites W3082231643 @default.
- W4310364518 cites W3085721524 @default.
- W4310364518 cites W3087406661 @default.
- W4310364518 cites W3094768164 @default.
- W4310364518 cites W3112105690 @default.
- W4310364518 cites W3164603853 @default.
- W4310364518 cites W3182005990 @default.