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• W4310364901 abstract "We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (PKD) progression. In this study, we examined the influence of the inflammasome, a key part of the innate immune system, on PKD. The inflammasome is a system of molecular sensors, receptors, and scaffolds that responds to stimuli like cellular damage or microbes by activating Caspase-1, and generating critical mediators of the inflammatory milieu, including IL-1β and IL-18. We provide evidence that the inflammasome is primed in PKD, as multiple inflammasome sensors were upregulated in cystic kidneys from human ADPKD patients, as well as in kidneys from both orthologous ( PKD1 RC/RC or RC/RC) and non-orthologous ( jck ) mouse models of PKD. Further, we demonstrate that the inflammasome is activated in female RC/RC mice kidneys, and this activation occurs in renal leukocytes, primarily in CD11c+ cells. Knock-out of Casp1 , the gene encoding Caspase-1, in the RC/RC mice significantly restrained cystic disease progression in female mice, implying sex-specific differences in the renal immune environment. RNAseq analysis implicated the promotion of MYC/YAP pathways as a mechanism underlying the pro-cystic effects of the Caspase-1/inflammasome in females. Finally, treatment of RC/RC mice with hydroxychloroquine, a widely used immunomodulatory drug that has been shown to inhibit the inflammasome, protected renal function specifically in females and restrained cyst enlargement in both male and female RC/RC mice. Collectively, these results provide evidence for the first time that the activated Caspase-1/inflammasome promotes cyst expansion and disease progression in PKD, particularly in females. Moreover, the data suggest that this innate immune pathway may be a relevant target for therapy in PKD." @default.
• W4310364901 created "2022-12-09" @default.
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• W4310364901 date "2022-11-29" @default.
• W4310364901 modified "2023-09-26" @default.
• W4310364901 title "Caspase-1 and the inflammasome promote polycystic kidney disease progression" @default.
• W4310364901 cites W1513095566 @default.
• W4310364901 cites W1594650921 @default.
• W4310364901 cites W1596844935 @default.
• W4310364901 cites W1929151207 @default.
• W4310364901 cites W1973171955 @default.
• W4310364901 cites W1985446247 @default.
• W4310364901 cites W1991937960 @default.
• W4310364901 cites W2003535733 @default.
• W4310364901 cites W2006938023 @default.
• W4310364901 cites W2008261126 @default.
• W4310364901 cites W2016499189 @default.
• W4310364901 cites W2016741118 @default.
• W4310364901 cites W2018619594 @default.
• W4310364901 cites W2032925403 @default.
• W4310364901 cites W2038841741 @default.
• W4310364901 cites W2039530311 @default.
• W4310364901 cites W2052369091 @default.
• W4310364901 cites W2063740184 @default.
• W4310364901 cites W2070050178 @default.
• W4310364901 cites W2072304718 @default.
• W4310364901 cites W2077589940 @default.
• W4310364901 cites W2078789307 @default.
• W4310364901 cites W2079882002 @default.
• W4310364901 cites W2085260843 @default.
• W4310364901 cites W2085346322 @default.
• W4310364901 cites W2086605453 @default.
• W4310364901 cites W2089042234 @default.
• W4310364901 cites W2095590314 @default.
• W4310364901 cites W2096538221 @default.
• W4310364901 cites W2096541584 @default.
• W4310364901 cites W2098023402 @default.
• W4310364901 cites W2100704215 @default.
• W4310364901 cites W2106243893 @default.
• W4310364901 cites W2111897512 @default.
• W4310364901 cites W2113325631 @default.
• W4310364901 cites W2116125371 @default.
• W4310364901 cites W2116414236 @default.
• W4310364901 cites W2119449193 @default.
• W4310364901 cites W2120488567 @default.
• W4310364901 cites W2120967762 @default.
• W4310364901 cites W2124577658 @default.
• W4310364901 cites W2135053341 @default.
• W4310364901 cites W2138285875 @default.
• W4310364901 cites W2141869612 @default.
• W4310364901 cites W2142446574 @default.
• W4310364901 cites W2143076230 @default.
• W4310364901 cites W2144688736 @default.
• W4310364901 cites W2147100699 @default.
• W4310364901 cites W2148407960 @default.
• W4310364901 cites W2156301166 @default.
• W4310364901 cites W2187010423 @default.
• W4310364901 cites W2278508017 @default.
• W4310364901 cites W2314626866 @default.
• W4310364901 cites W2345356016 @default.
• W4310364901 cites W2431987552 @default.
• W4310364901 cites W2477098317 @default.
• W4310364901 cites W2491072978 @default.
• W4310364901 cites W2510768527 @default.
• W4310364901 cites W2554031258 @default.
• W4310364901 cites W2560774983 @default.
• W4310364901 cites W2585855774 @default.
• W4310364901 cites W2613648230 @default.
• W4310364901 cites W2733169187 @default.
• W4310364901 cites W2735527928 @default.
• W4310364901 cites W2766704070 @default.
• W4310364901 cites W2768981280 @default.
• W4310364901 cites W2790847363 @default.
• W4310364901 cites W2796286456 @default.
• W4310364901 cites W2799670412 @default.
• W4310364901 cites W2800484870 @default.
• W4310364901 cites W2808015402 @default.
• W4310364901 cites W2814758512 @default.
• W4310364901 cites W2883208713 @default.
• W4310364901 cites W2884445384 @default.
• W4310364901 cites W2885895890 @default.
• W4310364901 cites W2887043640 @default.
• W4310364901 cites W2888346415 @default.
• W4310364901 cites W2895524712 @default.
• W4310364901 cites W2897808754 @default.
• W4310364901 cites W2899618291 @default.

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