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- W4310366790 abstract "Autoinflammatory disorders is a group of inherited disorders characterized by recurrent episodes of fever and inflammation, in the absence of infections, neoplasia, or autoimmunity. These disorders have in common a dysregulated inflammatory response and among them, inflammasome-related autoinflammatory disorders or inflammasomopathies are a consequence of inappropriate activation of inflammasomes with the consequent overproduction of cytokines of the IL-1 family. However, other autoinflammatory disorders are type I interferonopathies, deficiency of ADA2, disorders associated with aberrant TNF or NF-κB signaling, and inflammatory actinopathies, in which some of them the inflammasome could be activated. These disorders are treated with anticytokines biological drugs, but novel small molecules targeting inflammasomes are promising new therapeutic approaches." @default.
- W4310366790 created "2022-12-09" @default.
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- W4310366790 date "2023-01-01" @default.
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- W4310366790 title "Autoinflammatory disorders" @default.
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- W4310366790 doi "https://doi.org/10.1016/b978-0-323-91802-2.00007-4" @default.
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