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- W4310366791 abstract "Comprehensive transcriptome deep-sequencing has revealed that most of the typical eukaryotic genome is transcriptionally active, producing an astonishing array of both large and small noncoding RNA (ncRNA). Although the functions of many ncRNA are unclear, in general ncRNAs have the ability to influence gene expression at the transcriptional and post-transcriptional levels. Important categories of ncRNA are sncRNA, lncRNA, lincRNA, Y RNA, and circRNA. One type of small noncoding transcript, microRNA (miRNA), has been documented to have important regulatory roles in the modulation of gene expression by profoundly influencing the stability and translatability of mRNA. miRNAs are endogenous, noncoding regulatory molecules with a typical length of 20–22 nts. They are known to govern cellular and organism physiology at the levels of cell proliferation, differentiation, signal transduction, cellular senescence, apoptosis, and the initiation and progression of the disease state, to name a few examples. Thousands of miRNAs have already been identified in many organisms and have been added to the rapidly expanding miRNA database known as miRBase." @default.
- W4310366791 created "2022-12-09" @default.
- W4310366791 creator A5003710396 @default.
- W4310366791 date "2023-01-01" @default.
- W4310366791 modified "2023-09-25" @default.
- W4310366791 title "miRNA and other noncoding RNAs" @default.
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- W4310366791 doi "https://doi.org/10.1016/b978-0-323-90221-2.00035-7" @default.
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